Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrey S. Selyunin"'
Autor:
Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay
Publikováno v:
Toxins, Vol 13, Iss 6, p 424 (2021)
Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising. Recently,
Externí odkaz:
https://doaj.org/article/8e84cdf6d6014652a55ee66b10b0e415
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 878-891 (2014)
Bidirectional vesicular transport between the endoplasmic reticulum (ER) and Golgi is mediated largely by ARF and Rab GTPases, which orchestrate vesicle fission and fusion, respectively. How their activities are coordinated in order to define the suc
Externí odkaz:
https://doaj.org/article/15cb41b465e049c9a0a7ea2cbcdd2816
Publikováno v:
The Journal of Cell Biology
Toxins produced by Shigella bacteria undergo endosome-to-Golgi retrograde trafficking to evade degradation in the lysosome and reach the cytosol. Selyunin et al. performed a genome-wide siRNA screen and identify host factors required for the transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e12be1a4dac7e3d2716aca51414d3a
https://doi.org/10.1083/jcb.201704015
https://doi.org/10.1083/jcb.201704015
Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis
Publikováno v:
Life Science Alliance
This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.
Shiga toxin 1 (STx1) and 2 (STx2), produced by
Shiga toxin 1 (STx1) and 2 (STx2), produced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d9acbe844f5635a73ae97482d934bc
http://europepmc.org/articles/PMC6599968
http://europepmc.org/articles/PMC6599968
Publikováno v:
Traffic. 16:1270-1287
Shiga toxin-producing Escherichia coli (STEC) produce two types of Shiga toxin (STx): STx1 and STx2. The toxin A-subunits block protein synthesis, while the B-subunits mediate retrograde trafficking. STEC infections do not have definitive treatments,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5269b16930cd5e63d6996da5fdbd2953
https://doi.org/10.1111/tra.12338
https://doi.org/10.1111/tra.12338
Publikováno v:
Cell reports
Cell Reports, Vol 6, Iss 5, Pp 878-891 (2014)
Cell Reports, Vol 6, Iss 5, Pp 878-891 (2014)
Summary Bidirectional vesicular transport between the endoplasmic reticulum (ER) and Golgi is mediated largely by ARF and Rab GTPases, which orchestrate vesicle fission and fusion, respectively. How their activities are coordinated in order to define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b31813592d070bed77387a546dce4
http://europepmc.org/articles/PMC4017587
http://europepmc.org/articles/PMC4017587
Autor:
Steven M. Patrie, Neal M. Alto, James M. Ertelt, Sing Sing Way, Bethany A. Weigele, Andrey S. Selyunin, Nikolay Burnaevskiy, Daniel A. Plymire, Thomas G. Fox
Publikováno v:
Nature. 496:106-109
An irreversible mechanism of protein demyristoylation catalysed by invasion plasmid antigen J (IpaJ), a Shigella flexneri type III effector protein with cysteine protease activity, is described. Nearly one per cent of eukaryotic proteins are modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681d6a7bb20c521f79d5fc6b967bc42
https://doi.org/10.1038/nature12004
https://doi.org/10.1038/nature12004
Autor:
Neal M. Alto, Andrey S. Selyunin
Publikováno v:
Small GTPases. 2:217-221
Small Rho GTPases regulate a diverse range of cellular behavior within a cell. Their ability to function as molecular switches in response to a bound nucleotide state allows them to regulate multiple dynamic processes, including cytoskeleton organiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3903e0b29431a267b0b229ec786df1a0
https://doi.org/10.4161/sgtp.2.4.16704
https://doi.org/10.4161/sgtp.2.4.16704
Publikováno v:
Traffic (Copenhagen, Denmark). 16(12)
Shiga toxin-producing Escherichia coli (STEC) produce two types of Shiga toxin (STx): STx1 and STx2. The toxin A-subunits block protein synthesis, while the B-subunits mediate retrograde trafficking. STEC infections do not have definitive treatments,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f4c6bd55318f028e3e33dec50267dbd
https://pubmed.ncbi.nlm.nih.gov/26420131
https://pubmed.ncbi.nlm.nih.gov/26420131
Autor:
L. Evan Reddick, Diana R. Tomchick, Robert C. Orchard, Bethany A. Weigele, Sarah E. Sutton, Andrey S. Selyunin, Stefan Bresson, Neal M. Alto
Pathogenic strains of Escherichia coli translocate many proteins into the host cell to promote virulence. The structure of one of these proteins, EspG from E. coli O157:H7, has been determined in a complex with two host enzymes and its mechanism diss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23843a0fc83a35dbb7c747d269dd0b8
https://europepmc.org/articles/PMC3675890/
https://europepmc.org/articles/PMC3675890/
