Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrey Rymar"'
Autor:
Rakshamani Tripathi, Zulong Liu, Aditi Jain, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Resistance to BRAF/MEK inhibitors is a major impediment to long-term survival for patients with BRAF-mutant melanomas. Here, the authors show that ABL kinases drive resistance by promoting MEK/ERK reactivation and the FDA-approved ABL kinase inhibito
Externí odkaz:
https://doaj.org/article/7126349dcc164a17b73b14d99a4c497c
Autor:
Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in ne
Externí odkaz:
https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff
Autor:
Daheng He, Marika Nespi, Zulong Liu, Christina Meeks, Anastasia Lyon, Jinpeng Liu, Andrey Rymar, Peng Wang, Chi Wang, Rina Plattner, Melissa Wilson, Aditi Jain, Rakshamani Tripathi, Dana Richards
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Metastatic melanoma remains an incurable disease for many patients due to the limited success of targeted and immunotherapies. BRAF and MEK inhibitors reduce metastatic burden for patients with melanomas harboring BRAF mutations; however, most eventu
Autor:
Elton Chan, Evan Markegard, Ross A. Okimoto, Luping Lin, Trever G. Bivona, Andrey Rymar, Victor Olivas, Xiao Chen, Dana S. Neel, Golzar Hemmati, Gideon Bollag
Publikováno v:
Proceedings of the National Academy of Sciences. 113:13456-13461
Oncogenic activation of protein kinase BRAF drives tumor growth by promoting mitogen-activated protein kinase (MAPK) pathway signaling. Because oncogenic mutations in BRAF occur in ∼2–7% of lung adenocarcinoma (LA), BRAF-mutant LA is the most fre
Autor:
Gaston Habets, Parmveer Singh, Gideon Bollag, Brian L. West, Lindsay A. Hohsfield, Andrey Rymar, Prabha N. Ibrahim, Stephanie Broome, Joshua D. Crapser, Garson Tsang, Elizabeth E. Spangenberg, Marika Nespi, Elizabeth A. Burton, Paul Severson, Jason Walters, Kim N. Green, Chao Zhang, Jack Lin, Jiazhong Zhang, Wayne Spevak, Ying Zhang, Nicole Y. Phan
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications
Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed40cee7378de96501838a791a1537ee
https://escholarship.org/uc/item/6062s7cq
https://escholarship.org/uc/item/6062s7cq
Autor:
Qing Chang, Chao Zhang, Nathaniel A. Outmezguine, Jessica J. Tao, Mariano Barbacid, Yijun Gao, Neal Rosen, Andrey Rymar, Neilawattie M. Timaul, Rory Mcgriskin, Besnik Qeriqi, Elisa de Stanchina, Anthony Tao, Rona Yaeger, David M. Hyman, Na Na, Gideon Bollag, Hui Yong Zhao, Ying Zhang, Zhan Yao, Wenjing Su
Publikováno v:
Nature medicine
Activating BRAF mutants and fusions signal as RAS-independent constitutively active dimers with the exception of BRAF V600 mutant alleles which can function as active monomers1. Current RAF inhibitors are monomer selective, they potently inhibit BRAF
Autor:
Cody J. Peer, Rafael Cruz, Katherine E. Warren, Andrey Rymar, Cynthia McCully, John Glod, Arman Odabas, William D. Figg
Publikováno v:
Neuro-Oncology. 20:i157-i157
BACKGROUND: Pexidartinib (PLX3397) is a colony stimulating factor-1 receptor (CSF1R) inhibitor under clinical evaluation including potential CNS tumor treatment. This study aims to estimate CNS penetration of pexidartinib in a nonhuman primate (NHP)
Publikováno v:
Journal of Vascular Surgery. 53(6):80S-81S
Autor:
Andrey Rymarov, Natalia Parfenteva, Kęstutis Valančius, Sabina Paulauskaitė, Violeta Misevičiūtė
Publikováno v:
Journal of Environmental Engineering and Landscape Management, Vol 26, Iss 3 (2018)
Ecological problems are inherent in the issue of air quality in the buildings. The main goal thus becomes the creation of indoor clime, where concentration of the detrimental impurities, such as carbon dioxide, would not exceed established norms. Thu
Externí odkaz:
https://doaj.org/article/651c590e81e84a32b3f5f3cc7438757a