Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons

Autor: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Andrea Salonia, Francesco Montorsi, Francisco Wandosell, Keith Foster, François Giuliano, Alberto L. Epstein, Alejandro Aranda Muñoz

Publikováno v: Toxins, Vol 11, Iss 2, p 123 (2019)

A set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains (LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties have been assessed in primary cultures of rat embryonic dorsal root g

Externí odkaz: https://doaj.org/article/265b0f99c38147868e219a1280b3af80

Ring-like distribution of constitutive heterochromatin in bovine senescent cells.

Autor: Andrey Pichugin, Nathalie Beaujean, Xavier Vignon, Yegor Vassetzky

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e26844 (2011)

BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochroma

Externí odkaz: https://doaj.org/article/db0c1fb7ebdb4300899650bfb9705d50

Nuclear localization of translocation partners in differentiating B-cells

Autor: I. V. Sklyar, E. S. Vassetzky, Olga V. Iarovaia, Sergey V. Razin, Andrey Pichugin

Publikováno v: Doklady Biochemistry and Biophysics. 464:312-314

We studied the nuclear localization and relative position in the nuclear space of malignant translocation partner genes c-Myc, CCND1, and IGH locus in naive and differentiating B cells. We have shown that, during B-cell maturation, c-Myc and IGH loci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d991f8d9cfb08a21ef0edb9d1ddac8
https://doi.org/10.1134/s1607672915050129

Distinct Patterns of Colocalization of the CCND1 and CMYC Genes With Their Potential Translocation Partner IGH at Successive Stages of B-Cell Differentiation

Autor: Ilya, Sklyar, Olga V, Iarovaia, Alexey A, Gavrilov, Andrey, Pichugin, Diego, Germini, Tatiana, Tsfasman, Gersende, Caron, Thierry, Fest, Marc, Lipinski, Sergey V, Razin, Yegor S, Vassetzky

Publikováno v: Journal of Cellular Biochemistry
Journal of Cellular Biochemistry, Wiley, 2016, 117 (7), pp.1506-1510. ⟨10.1002/jcb.25516⟩
Journal of Cellular Biochemistry, 2016, 117 (7), pp.1506-1510. ⟨10.1002/jcb.25516⟩

The immunoglobulin heavy chain (IGH) locus is submitted to intra-chromosomal DNA breakages and rearrangements during normal B cell differentiation that create a risk for illegitimate inter-chromosomal translocations leading to a variety of B-cell mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::aca6eedfa2738c4eb8698c7b604a87fb
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01295670

Dynamics of constitutive heterochromatin: two contrasted kinetics of genome restructuring in early cloned bovine embryos

Autor: Gaetan Lehmann, Jean Paul Renard, Nathalie Beaujean, Pierre Adenot, Xavier Vignon, Andrey Pichugin, Christophe Audouard, Daniel Le Bourhis

Publikováno v: Reproduction
Reproduction, BioScientifica, 2010, 139 (1), pp.129-137. ⟨10.1530/REP-08-0435⟩

International audience; Efficient reprograming of the donor cell genome in nuclear transfer (NT) embryos is linked to the ability of the embryos to sustain full-term development. As the nuclear architecture has recently emerged as a key factor in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f371ec3b19ddee654469afe77a8964
https://doi.org/10.1530/rep-08-0435