Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Andrey N. Luchnik"'
1
Chromosome instability induced by mutations in TAD anchors leads to tumors
Autor: Andrey N. Luchnik
Publikováno v: Genome Instability & Disease. 2:309-329
In the light of recent data, a way is described between mutations in TAD anchors and stimulation of tumor growth driven by chromosome instability. At the end of this way every tumor sacrifices by a portion of its cells, dying necrotically, to stimula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98763fa0304589cf1a5b28a100913e1d
https://doi.org/10.1007/s42764-021-00050-1
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3
A model of self-maintenance of in vivo malignant growth not dependent on tumour type or origin: syndrome of everlasting wound healing
Autor: Andrey N. Luchnik
Publikováno v: Cancer biologytherapy. 2(4)
The common mechanism of permanent growth maintenance in all types of malignant tumours is proposed. According to the model, the main event, stimulating tumour growth is the stochastic but permanent death of a proportion of tumour cells as a result of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b89588ab09d9f489b6dbdc323986427
https://pubmed.ncbi.nlm.nih.gov/14508102
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5
Long-distance signal transfer in transcriptionally active chromatin - how does it occur?
Autor: Andrey N. Luchnik
Publikováno v: BioEssays. 3:249-252
Gene transcription in eukaryotes is associated with conformational changes of a large area of chromatin adjacent to a gene. This rearrangement may involve the whole loop (topological domain) to which a given gene belongs. Regulatory events associated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea28df466397364b372f24b6db6fcab
https://doi.org/10.1002/bies.950030604
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6
DNA topological linking numbers in malignantly transformed Syrian hamster cells
Autor: Andrey N. Luchnik, Vadim M. Glaser
Publikováno v: Molecular and General Genetics MGG. 183:553-556
The topological linking numbers in closed superhelical loops of nuclear DNA were measured as the density of DNA topological turns ('titratable superhelical turns') per unit length of DNA by means of sedimentation of superhelical DNA (in nucleoids) in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0352c9f7549096e2b4f7656b639a4aaf
https://doi.org/10.1007/bf00268781
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7
Decrease in the number of DNA topological turns during friend erythroleukemia differentiation
Autor: Vadim M. Glaser, Andrey N. Luchnik
Publikováno v: Molecular and General Genetics MGG. 178:459-463
Murine erythroleukemia cells were induced to undergo erythroid differentiation by growing in presence of dimethylsulfoxide, butyric acid or actinomycin D. topological linking numbers in closed loops of nuclear DNA were measured by means of centrifuga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e8e2ee5c19f93c14b8bf8d4d7e6de7
https://doi.org/10.1007/bf00270500
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8
Evidence for a novel conformational transition in superhelical DNA
Autor: Andrey N. Luchnik
Publikováno v: Journal of Biological Physics. 13:48-54
On the assumption that the dependence of the electrophoretic mobility of superhelical DNA upon the number of tertiary turns (Wr) is a monotonously increasing function devoid of points of inflection, it is concluded that the inflection (change of sign
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f0401effd09abe2b41011f700d9c1ae
https://doi.org/10.1007/bf01857795
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10
Inhibition of transcription in eukaryotic cells by X-irradiation: relation to the loss of topological constraint in closed DNA loops
Autor: Andrey N. Luchnik, T A Hisamutdinov, G P Georgiev
X irradiation was found to inhibit in vivo transcription in mammalian, yeast, insect and avian cells in a dose-dependent manner. Measurements of DNA nicking indicated that about one DNA single-strand break per estimated DNA loop (domain) length is su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3b774dd8508dce8b5a761307307ab8
https://europepmc.org/articles/PMC336726/
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