Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Andrey E. Shchekotikhin"'
Autor:
Andrey V. Stepanov, Vladimir N. Yarovenko, Darina I. Nasyrova, Lyubov G. Dezhenkova, Igor O. Akchurin, Mickhail M. Krayushkin, Valentina V. Ilyushenkova, Andrey E. Shchekotikhin, Evgeny V. Tretyakov
Publikováno v:
Molecules, Vol 29, Iss 20, p 4966 (2024)
Gossypol and its derivatives arouse interest due to their broad spectrum of biological activities. Despite its wide potential application, there is no reported example of gossypol derivatives bearing stable radical functional groups. The first gossyp
Externí odkaz:
https://doaj.org/article/850fdfb4982a4c58bb38beb7163b7f2a
Autor:
Diana I. Salnikova, Stepan K. Krymov, Danila V. Sorokin, Fedor B. Bogdanov, Olga E. Andreeva, Alvina I. Khamidullina, Andrey E. Shchekotikhin, Alexander M. Scherbakov
Publikováno v:
Proceedings, Vol 100, Iss 1, p 4 (2024)
Introduction: The design and development of antitumor compounds based on an isatin core led to the synthesis of 1-substituted isatin-5-sulfonamides with potent antiproliferative activity [...]
Externí odkaz:
https://doaj.org/article/1374ebb7d9014592ae7a54f751b6d95c
Autor:
Inna A. Volynkina, Elena N. Bychkova, Anastasiia O. Karakchieva, Alexander S. Tikhomirov, George V. Zatonsky, Svetlana E. Solovieva, Maksim M. Martynov, Natalia E. Grammatikova, Andrey G. Tereshchenkov, Alena Paleskava, Andrey L. Konevega, Petr V. Sergiev, Olga A. Dontsova, Ilya A. Osterman, Andrey E. Shchekotikhin, Anna N. Tevyashova
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 187 (2024)
The sustained rise of antimicrobial resistance (AMR) causes a strong need to develop new antibacterial agents. One of the methods for addressing the problem of antibiotic resistance is through the design of hybrid antibiotics. In this work, we propos
Externí odkaz:
https://doaj.org/article/807737912d584410b6286cfbdcf876e1
Autor:
Maxim E. Zhidkov, Maria A. Sidorova, Polina A. Smirnova, Oleg A. Tryapkin, Andrey V. Kachanov, Alexey V. Kantemirov, Lyubov G. Dezhenkova, Natalia E. Grammatikova, Elena B. Isakova, Andrey E. Shchekotikhin, Marina A. Pak, Olga N. Styshova, Anna A. Klimovich, Aleksandr M. Popov
Publikováno v:
Marine Drugs, Vol 22, Iss 2, p 53 (2024)
Based on the results of our own preliminary studies, the derivative of the marine alkaloid fascaplysin containing a phenyl substituent at C-9 was selected to evaluate the therapeutic potential in vivo and in vitro. It was shown that this compound has
Externí odkaz:
https://doaj.org/article/a3843695dc414199a26dc76a21fa30e7
Autor:
Stepan K. Krymov, Diana I. Salnikova, Lyubov G. Dezhenkova, Fedor B. Bogdanov, Alexander A. Korlyukov, Alexander M. Scherbakov, Andrey E. Shchekotikhin
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 32 (2023)
Breast and other estrogen receptor α-positive cancers tend to develop resistance to existing drugs. Chalcone derivatives possess anticancer activity based on their ability to form covalent bonds with targets acting as Michael acceptors. This study a
Externí odkaz:
https://doaj.org/article/bbd2de3f85e34d55b95a8907e749723a
Autor:
Danila Vladimirovich Sorokin, Stepan K. Krymov, Margo N. Cherednichenko, Alexandra L. Mikhaylova, Diana I. Salnikova, Andrey E. Shchekotikhin, Alexander M. Scherbakov
Publikováno v:
Engineering Proceedings, Vol 56, Iss 1, p 192 (2023)
Cancer is one of the leading causes of death worldwide, accounting for about 10 million deaths a year, or nearly one in six deaths. The most common types of cancer are breast, colorectal, lung, and prostate cancers. Prolonged application of hormone d
Externí odkaz:
https://doaj.org/article/8a14a4bcc81748b7bb8579e185b9f9e3
Autor:
Svetlana G. Frolova, Aleksey A. Vatlin, Dmitry A. Maslov, Buhari Yusuf, Galina I. Buravchenko, Olga B. Bekker, Ksenia M. Klimina, Svetlana V. Smirnova, Lidia M. Shnakhova, Irina K. Malyants, Arseniy I. Lashkin, Xirong Tian, Md Shah Alam, George V. Zatonsky, Tianyu Zhang, Andrey E. Shchekotikhin, Valery N. Danilenko
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1565 (2023)
The World Health Organization (WHO) reports that tuberculosis (TB) is one of the top 10 leading causes of global mortality. The increasing incidence of multidrug-resistant TB highlights the urgent need for an intensified quest to discover innovative
Externí odkaz:
https://doaj.org/article/7b6df8ca6f984542aff888c5ab626b96
Autor:
Michael I. Treshchalin, Vasilisa A. Polozkova, Elena I. Moiseenko, Andrey E. Shchekotikhin, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Eleonora R. Pereverzeva
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1569 (2023)
Glycopeptide antibiotics are still in demand in clinical practice for treating infections caused by resistant gram-positive pathogens; however, their use is limited due to severe adverse reactions. Their predominant types of side effects are immunogl
Externí odkaz:
https://doaj.org/article/0dab87cac10848d88f5e48f6cad1f307
Publikováno v:
Pharmaceuticals, Vol 16, Iss 8, p 1174 (2023)
N-Oxides of heterocyclic compounds are the focus of medical chemistry due to their diverse biological properties. The high reactivity and tendency to undergo various rearrangements have piqued the interest of synthetic chemists in heterocycles with N
Externí odkaz:
https://doaj.org/article/769313d16e9e42ad9c412de71613c8d4
Autor:
Aleksey A. Vatlin, Olga B. Bekker, Ludmila N. Lysenkova, Andrey E. Shchekotikhin, Valery N. Danilenko
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 22, Iss , Pp 47-53 (2020)
Objectives: The aim of this study was to obtain Streptomyces xinghaiensis (fradiae) ATCC 19609 mutants resistant to oligomycin A and its derivatives and to identify the underlying mechanism of resistance. This study was based on the premise that S. x
Externí odkaz:
https://doaj.org/article/9a60bb99d86d4dc2a504df6bea35164d