Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Andrey E. Belous"'
Autor:
Andrey E. Belous, Truman M. Earl, Clayton D. Knox, Ian B. Nicoud, Christopher D. Anderson, Ravi S. Chari, Janene Pierce, Christopher M. Jones
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G623-G630
Ischemia-reperfusion (I/R) injury is a commonly encountered clinical problem in liver surgery and transplantation. The pathogenesis of I/R injury is multifactorial, but mitochondrial Ca2+ overload plays a central role. We have previously defined a no
Autor:
Christopher D. Anderson, Ian B. Nicoud, Ravi S. Chari, Janene Pierce, Christopher M. Jones, Andrey E. Belous
Publikováno v:
Journal of Surgical Research. 141:234-240
Background Purinergic (P2Y) receptors play an important role in intracellular Ca 2+ regulation in hepatocytes. Prevention of mitochondrial Ca 2+ (mCa 2+ ) overload during ischemic conditions prevents cellular cell death during the early reperfusion p
Autor:
Janene Pierce, Christopher D. Anderson, Clayton D. Knox, Christopher M. Jones, Ian B. Nicoud, Andrey E. Belous, Ravi S. Chari
Publikováno v:
Transplantation. 81:567-572
Background. Graft failure due to cold ischemia (CI) injury remains a significant problem during liver transplantation. During CI, the consumption ofATP and the increase in cellular Ca 2+ concentration may result in mitochondrial Ca 2+ (mCa 2+ ) overl
Autor:
Christopher D. Anderson, Janene Pierce, Ian B. Nicoud, Clayton D. Knox, Andrey E. Belous, Ravi S. Chari
Publikováno v:
Liver Transplantation. 11:663-668
Hepatic warm ischemia and reperfusion (IR) injury occurs in many clinical situations and has an important link to subsequent hepatic failure. The pathogenesis of this injury involves numerous pathways, including mitochondrial-associated apoptosis. We
Autor:
Andrey E. Belous, Clayton D. Knox, C. Wright Pinson, Aya Wakata, Christopher D. Anderson, Ian B. Nicoud, Ravi S. Chari, Janene Pierce
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 287:G533-G540
Mitochondrial Ca2+(mCa2+) handling is an important regulator of liver cell function that controls events ranging from cellular respiration and signal transduction to apoptosis. Cytosolic Ca2+enters mitochondria through the ruthenium red-sensitive mCa
Autor:
C. Wright Pinson, Aya Wakata, Ravi S. Chari, Christopher D. Anderson, Clayton D. Knox, Andrey E. Belous, Ian B. Nicoud, Janene Pierce
Publikováno v:
American Journal of Transplantation. 4:352-362
Mitochondrial calcium (mCa + 2) overload occurs during cold preservation and is an integral part of mitochondrial-dependent apoptotic pathways. We investigated the role of mCa + 2 overload in cell death following hypothermic storage using HepG2 cells
Autor:
Christopher D. Anderson, Clayton D. Knox, Ravi S. Chari, Andrey E. Belous, C. Wright Pinson, Janene Pierce, Ian B. Nicoud
Publikováno v:
Transplantation. 75:1717-1723
Graft dysfunction as a result of preservation injury remains a major clinical problem in liver transplantation. This is related in part to accumulation of mitochondrial calcium. In an attempt to sustain cell and mitochondrial integrity during ischemi
Autor:
Ian B. Nicoud, C. Wright Pinson, Janene Pierce, Christopher D. Anderson, Andrey E. Belous, Clayton D. Knox, Ravi S. Chari
Publikováno v:
Journal of Surgical Research. 111:284-289
Graft dysfunction as a result of preservation injury remains a major clinical problem in liver transplantation. This is related in part to accumulation of mitochondrial calcium (Ca(2+)), which has been linked to activation of proapoptotic factors. We
Autor:
Paul E. Wise, L. James Wudel, Andrey E. Belous, Tara M. Allos, Samuel J. Kuhn, Irene D. Feurer, M. Kay Washington, C. Wright Pinson, William C. Chapman
Publikováno v:
The American Surgeon. 68:553-562
Bile leaks occur in up to 27 per cent of liver transplant patients after biliary reconstruction. Synthetic sealants have not been investigated for these biliary procedures. We performed a randomized controlled study to evaluate a novel absorbable pol
Publikováno v:
Liver Transplantation. 7:132-139
The accumulation of intracellular calcium ([Ca(2+)](i)) caused by ischemia-reperfusion during liver transplantation has been implicated as a factor leading to primary graft nonfunction. Plasma membrane (PM) and endoplasmic reticulum (ER) Ca(2+)-adeno