Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Andrey A. Abramov"'
Publikováno v:
Antioxidants, Vol 13, Iss 9, p 1121 (2024)
Despite recent technological progress, carbon monoxide poisoning is still one of the leading causes of domestic and industrial morbidity and mortality. The brain is particularly vulnerable to CO toxicity, and thus the majority of survivors develop de
Externí odkaz:
https://doaj.org/article/8ba9d6a7a700444a9e00e8834082249d
Autor:
Andrey Y. Vinokurov, Marina Y. Pogonyalova, Larisa Andreeva, Andrey Y. Abramov, Plamena R. Angelova
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 6, Iss , Pp 100187- (2024)
Alteration of mitochondrial metabolism by various mutations or toxins leads to various neurological conditions. Age-related changes in energy metabolism could also play the role of a trigger for neurodegenerative disorders. Nonetheless, it is not cle
Externí odkaz:
https://doaj.org/article/a098f1d47ee0433fb184e2d3dc30abc0
Autor:
Artyom Y. Baev, Andrey Y. Vinokurov, Elena V. Potapova, Andrey V. Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Publikováno v:
Cells, Vol 13, Iss 7, p 648 (2024)
Neurodegenerative diseases are chronic conditions occurring when neurons die in specific brain regions that lead to loss of movement or cognitive functions. Despite the progress in understanding the mechanisms of this pathology, currently no cure exi
Externí odkaz:
https://doaj.org/article/4fac893392b44e4994f77401b8f77550
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Autor:
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S. Nirujogi, Anna I. Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S. Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R. Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A. Rusakov, Dario R. Alessi, Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an SNCA mutation d
Externí odkaz:
https://doaj.org/article/fc1ba7fa6d614cbe962ce2b5a05c4fa6
Autor:
Elena F. Shevtsova, Plamena R. Angelova, Olga A. Stelmashchuk, Noemi Esteras, Nataliia A. Vasil’eva, Andrey V. Maltsev, Pavel N. Shevtsov, Alexander V. Shaposhnikov, Vladimir P. Fisenko, Sergey O. Bachurin, Andrey Y. Abramov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract All forms of dementia including Alzheimer’s disease are currently incurable. Mitochondrial dysfunction and calcium alterations are shown to be involved in the mechanism of neurodegeneration in Alzheimer’s disease. Previously we have desc
Externí odkaz:
https://doaj.org/article/65ffb49b09fd4bf48fa46b6b76b2a84c
Autor:
Noemí Esteras, Thomas S. Blacker, Evgeny A. Zherebtsov, Olga A. Stelmashuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102672- (2023)
The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy metabolism. Energy production and antioxidant defence employ NADH
Externí odkaz:
https://doaj.org/article/4123d5a1ee434661a0e1f99bf4759861
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102598- (2023)
Carbon monoxide (CO) poisoning is one of the leading causes of toxic mortality and morbidity. We have studied the generation of reactive oxygen species in cortical neurons in culture in response to toxic doses of CO exposure. Fluorescence microscopy
Externí odkaz:
https://doaj.org/article/d49d50def0a14802967a1643ad413bda
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Abstract Human iPSC lines represent a powerful translational model of tauopathies. We have recently described a pathophysiological phenotype of neuronal excitability of human cells derived from the patients with familial frontotemporal dementia and p
Externí odkaz:
https://doaj.org/article/1cbd9bad247941769df13f43f12c4042
Autor:
Plamena R. Angelova, Annarein J.C. Kerbert, Abeba Habtesion, Andrew Hall, Andrey Y. Abramov, Rajiv Jalan
Publikováno v:
JHEP Reports, Vol 4, Iss 8, Pp 100510- (2022)
Background & Aims: In cirrhosis, astrocytic swelling is believed to be the principal mechanism of ammonia neurotoxicity leading to hepatic encephalopathy (HE). The role of neuronal dysfunction in HE is not clear. We aimed to explore the impact of hyp
Externí odkaz:
https://doaj.org/article/3dd4c18ff4954ee1b0ec660b75bea25c