Test-statistic inflation in methylome-wide association studies

Autor: Jerry Guintivano, Andrey A Shabalin, Robin F. Chan, David R. Rubinow, Patrick F. Sullivan, Samantha Meltzer-Brody, Karolina a Aberg, Edwin J. C. G. van den Oord

Publikováno v: Epigenetics, Vol 15, Iss 11, Pp 1163-1166 (2020)

Recent years have seen a surge of methylome-wide association studies (MWAS). We observed that many of these studies suffer from test statistic inflation that is most likely caused by commonly used quality control (QC) pipelines not going far enough t

Externí odkaz: https://doaj.org/article/c2f0ef98a3c445239be0d800d7c7a258

Harnessing changes in open chromatin determined by ATAC-seq to generate insulin-responsive reporter constructs

Autor: Collin B. Merrill, Austin B. Montgomery, Miguel A. Pabon, Andrey A. Shabalin, Aylin R. Rodan, Adrian Rothenfluh

Publikováno v: BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract Background Gene regulation is critical for proper cellular function. Next-generation sequencing technology has revealed the presence of regulatory networks that regulate gene expression and essential cellular functions. Studies investigating

Externí odkaz: https://doaj.org/article/9c6a6656befe4806903a1fb4a4db4f16

Genetic association study of childhood aggression across raters, instruments, and age

Autor: Hill F. Ip, Camiel M. van der Laan, Eva M. L. Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M. Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A. Wang, Gretchen Saunders, Ville Karhunen, Anke R. Hammerschlag, Daniel E. Adkins, Richard Border, Roseann E. Peterson, Joseph A. Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S. Ahluwalia, Felix R. Day, Jouke-Jan Hottenga, Andrea G. Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J. Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G. Scott, Anna Vinkhuyzen, Andrey A. Shabalin, Robin Corley, Luke M. Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E. Davies, Erik A. Ehli, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C.E.M. Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C. Verhulst, Najaf Amin, Alyce M. Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J. Rose, André G. Uitterlinden, Andrew C. Heath, Pamela Madden, Jan Haavik, Jennifer R. Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S. Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K. Henders, Abdullah Mamun, Jackob M. Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L. Wall, Judy L. Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T. Raitakari, John R. B. Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L. John Horwood, Martin Kennedy, Richie Poulton, Lindon J. Eaves, Hermine H. Maes, John Hewitt, William E. Copeland, Elizabeth J. Costello, Gail M. Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E. Moffitt, Andrew Whitehouse, Craig E. Pennell, Kelly L. Klump, S. Alexandra Burt, Danielle M. Dick, Ted Reichborn-Kjennerud, Nicholas G. Martin, Sarah E. Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A. Hartman, Albertine J. Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors

Externí odkaz: https://doaj.org/article/882fa84e3ace4249a3c5e7bb582ea021

The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders

Autor: Anna R. Docherty, Vimla Aggarwal, James M. McNamara, Ayan Malakar, Daniel Hughes, Andrey A. Shabalin, Anat Grossman-Jonish, Lior Greenbaum, Gundula Povysil, Shannon Delaney, Hann-Shyan Hwang, Evan H. Baugh, David Goldstein, Anna Alkelai, Emma P. Peabody, Matthew B. Harms, Sahar Gelfman, Bernard Lerer, Vaidehi Jobanputra, Ann E. Pulver, Anthony W. Zoghbi, Erin L. Heinzen

Publikováno v: Molecular Psychiatry. 27:1435-1447

Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders is not well studied. We investigated the yield of clinical WGS anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::272b15da584e5c9c1345b62e95aaea0b
https://doi.org/10.1038/s41380-021-01383-9

Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach

Autor: Hilary Coon, Anna R. Docherty, Amanda V. Bakian, Eric T. Monson, Emily DiBlasi, Brooks R. Keeshin, Virginia L. Willour, Sheila E. Crowell, Niamh Mullins, Douglas Gray, Qingqin S. Li, Andrey A. Shabalin

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Translational Psychiatry

Bipolar disorder (BP) suicide death rates are 10–30 times greater than the general population, likely arising from environmental and genetic risk factors. Though suicidal behavior in BP has been investigated, studies have not addressed combined cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ce43d9f69cdf2673a4cafae517ee85
https://doaj.org/article/eaefc5bd42cf41b9a7782f258e8aff16