Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Andrey Sarafanov"'
Autor:
Andrey Sarafanov, Leonid Parunov, Philip Olivares, Svetlana Shestopal, John Pettersson, Haarin Chun, Mikhail Ovanesov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8134
Single-chain variable fragments (scFv) are antigen-recognizing variable fragments of antibodies (FV) where both subunits (VL and VH) are connected via an artificial linker. One particular scFv, iKM33, directed against blood coagulation factor VIII (F
Autor:
Andre Kajdacsy-Balla, Weihua Gao, Craig A. Beam, Marion Gray, Jose A. Centeno, Andrey Sarafanov, Todor I. Todorov, Virgilia Macias, Wei Min Liang
Publikováno v:
The Prostate. 71:1231-1238
Background: There are many studies on prostate cancer incidence and exposure to heavy metals such as cadmium, iron, selenium and zinc. Much less data is available on the possible influence of heavy metals on prostate cancer outcome. We and others hav
Autor:
Natalya M. Ananyeva, Alexey V. Khrenov, Evgueni L. Saenko, Robert Summers, Andrey Sarafanov, Fred Darr
Publikováno v:
Expert Opinion on Pharmacotherapy. 5:1061-1070
The mainstay in the treatment of haemophilia A is replacement therapy with repeated infusions of plasma-derived Factor VIII (FVIII) concentrates or recombinant FVIII products. While modern plasma-derived FVIII concentrates have an excellent safety pr
Autor:
Diana Kouiavskaia, Djuro Josic, Natalya M. Ananyeva, Evgueni L. Saenko, Midori Shima, Horst Schwinn, Alexey V. Khrenov, Andrey Sarafanov
Publikováno v:
Thrombosis Research. 105:87-93
Factor VIII (fVIII) is an essential component of the intrinsic pathway of blood coagulation. In this pathway, thrombin-activated fVIII (fVIIIa) functions as a cofactor for a serine protease factor IXa (fIXa), and their complex (Xase complex)activates
Autor:
Yevgen M Makogonenko, Natalya Gorlatova, Andrey Sarafanov, Natalya M. Ananyeva, Igor Pechik, Evgueni L. Saenko, Klaus P Radtke, Midori Shima
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 19(6)
Coagulation factor VIII interacts with several members of the low-density lipoprotein receptor family including low-density lipoprotein receptor-related protein, low-density lipoprotein receptor, and very low-density lipoprotein receptor. The present
Autor:
Gijsbert B. van der Voet, Florabel G. Mullick, Wayne B. Jonas, Jose A. Centeno, John A. Ives, Andrey Sarafanov, Todor I. Todorov
Publikováno v:
Biological trace element research. 125(1)
The use of dietary supplements has grown dramatically in the last decade. A large number of dietary and herbal supplements escape regulatory and quality control; components of these preparations are poisonous and may contain, among other toxins, heav
Autor:
Andrey Sarafanov, Evgueni L. Saenko
Publikováno v:
Analytical biochemistry. 328(1)
Autor:
Natalya M. Ananyeva, Klemens Löster, Midori Shima, Andrey Sarafanov, Christoph Kannicht, Alexey V. Khrenov, Gerhard Gruber, Horst Schwinn, Djuro Josic, Diana Kouiavskaia, Evgueni L. Saenko
Publikováno v:
Analytical biochemistry. 302(2)
Von Willebrand factor (vWf) functions both as a carrier of factor VIII (fVIII) in plasma and as an adhesive protein providing the primary link between collagen of the extracellular matrix and platelets sequestered from blood flow. The functional acti
Autor:
Horst Schwinn, Evgueni L. Saenko, Evan Behre, Djuro Josic, Natalya M. Ananyeva, Andrey Sarafanov, Midori Shima
Publikováno v:
Journal of chromatography. A. 921(1)
Binding of a coagulation factor VIII to phosphatidylserine-containing membranes is critical for exerting its cofactor activity. The use of surface plasmon resonance allows studying factor VIII interaction with immobilized phospholipids. In the presen
Publikováno v:
Trends in cardiovascular medicine. 9(7)
Blood coagulation factor VIII (fVIII) in its nonactivated form circulates in plasma in a complex with von Willebrand factor (vWf). Upon activation by thrombin- or factor Xa-mediated site-specific proteolysis, activated fVIII (fVIIIa) serves as a cofa