Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Andrey, Ugolkov"'
1
Akademický článek
VISTA expression and patient selection for immune-based anticancer therapy
Autor: Alexander S. Martin, Michael Molloy, Andrey Ugolkov, Reinhard W. von Roemeling, Randolph J. Noelle, Lionel D. Lewis, Melissa Johnson, Laszlo Radvanyi, Robert E. Martell
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
V-domain Ig suppressor of T-cell activation (VISTA) is a B7 family member that plays key roles in maintaining T cell quiescence and regulation of myeloid cell populations, which together establish it as a novel immunotherapy target for solid tumors.
Externí odkaz: https://doaj.org/article/420351bc0b4147789ec480bd514ae6a3
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2
Akademický článek
9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer
Autor: Hiroo Kuroki, Tsutomu Anraku, Akira Kazama, Vladimir Bilim, Masayuki Tasaki, Daniel Schmitt, Andrew P. Mazar, Francis J Giles, Andrey Ugolkov, Yoshihiko Tomita
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine kinase, has been identified as a potential therapeutic target in human bladder cancer. In the present study, we investigated the antitumor effect of a small molecule GSK-3β inhib
Externí odkaz: https://doaj.org/article/1423d830529042219401ce10296db960
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3
Akademický článek
Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models
Autor: Andrey Ugolkov, Wenan Qiang, Gennadiy Bondarenko, Daniel Procissi, Irina Gaisina, C. David James, James Chandler, Alan Kozikowski, Hendra Gunosewoyo, Thomas O'Halloran, Jeffrey Raizer, Andrew P. Mazar
Publikováno v: Translational Oncology, Vol 10, Iss 4, Pp 669-678 (2017)
Resistance to chemotherapy remains a major challenge in the treatment of human glioblastoma (GBM). Glycogen synthase kinase-3β (GSK-3β), a positive regulator of NF-κB–mediated survival and chemoresistance of cancer cells, has been identified as
Externí odkaz: https://doaj.org/article/f432510ec6364bdcb9e59663f8b8df25
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4
Nwani et al., Supplementary figures 1-11 from Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts
Autor: Olga V. Volpert, Andrew P. Mazar, Andrey Ugolkov, Oleksii Dubrovskyi, Elena Vinokour, Benilde Jimenez, Maria L. Deguiz, Nkechiyere G. Nwani
Supplemental Figure 1. Verification of PEDF knockdown Supplemental Figure 2. Verification of PEDF silencing in fibroblasts Supplemental Figure 3. The effect of PEDF expression in fibroblasts on tumor growth Supplemental Figure 4. The effect of endoge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1f376f8587641c7c6028f2125e2958
https://doi.org/10.1158/0008-5472.22411488
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7
Data from Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts
Autor: Olga V. Volpert, Andrew P. Mazar, Andrey Ugolkov, Oleksii Dubrovskyi, Elena Vinokour, Benilde Jimenez, Maria L. Deguiz, Nkechiyere G. Nwani
Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor prognosis and metastasis, but the contribution of stromal PEDF to cancer evolution is poorly understood. Therefore, we investigated the role of fibrobl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4e15eefa9bff335b82e8682f1c611e9
https://doi.org/10.1158/0008-5472.c.6508233.v1
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8
Data from Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity
Autor: Ming Zhao, Andrew Mazar, Thomas V. O'Halloran, Andy Tran, Raymond Bergan, Emily A. Waters, Lin Li, Gennadiy Bondarenko, Chad R. Haney, Andrey Ugolkov, Steven E. Johnson
Purpose:Response to toxicity in chemotherapies varies considerably from tissue to tissue and from patient to patient. An ability to monitor the tissue damage done by chemotherapy may have a profound impact on treatment and prognosis allowing for a pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01523a13197b9796799e48cc54bd1c6e
https://doi.org/10.1158/1078-0432.c.6526970.v1
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10
Supplemental Figures from Glycogen Synthase Kinase-3β: A Prognostic Marker and a Potential Therapeutic Target in Human Bladder Cancer
Autor: Yoshihiko Tomita, Tomoyuki Kato, Akira Nagaoka, Teiichi Motoyama, Andrey Ugolkov, Kaori Yuuki, Vladimir Bilim, Sei Naito
Supplemental Figure 1. Immunohistochemical staining of GSK-3β in low (A-C) and high (D-F) grade urothelial tumors. Supplemental Figure 2. Hoechst staining of T24 cancer cells treated with 3 distinct small molecule inhibitors of GSK-3 (AR-A014418, SB
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dd963d00ae2c104ad4d834bc765ac8
https://doi.org/10.1158/1078-0432.22442085.v1
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