Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Andrey, Kovalevsky"'
Autor:
Annie Aniana, Nashaat T. Nashed, Rodolfo Ghirlando, Leighton Coates, Daniel W. Kneller, Andrey Kovalevsky, John M. Louis
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MProWT) from precursor polyproteins. Upon expression, a model precursor of MProWT mediates its own release at its termini rapidly to yie
Externí odkaz:
https://doaj.org/article/cc30133938ec44e9a71f4b0649ccbb2c
Autor:
Victoria N. Drago, Claudia Campos, Mattea Hooper, Aliyah Collins, Oksana Gerlits, Kevin L. Weiss, Matthew P. Blakeley, Robert S. Phillips, Andrey Kovalevsky
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Pyridoxal 5’-phosphate (PLP)-dependent enzymes utilize a vitamin B6-derived cofactor to perform a myriad of chemical transformations on amino acids and other small molecules. Some PLP-dependent enzymes, such as serine hydroxymethyltransfer
Externí odkaz:
https://doaj.org/article/bf3a96d0bdb54c288779ee1d6dd360de
Autor:
Nashaat T. Nashed, Daniel W. Kneller, Leighton Coates, Rodolfo Ghirlando, Annie Aniana, Andrey Kovalevsky, John M. Louis
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Structural characterization and catalytic activity of SARS-CoV-2 main protease reveal minimal interface regions enabling dimer formation driven by inhibitor-induced conformational changes of the oxyanion loop.
Externí odkaz:
https://doaj.org/article/1e9e8033fd684980a02f9f29673a1d18
Autor:
Mikhail A. Hameedi, Erica T. Prates, Michael R. Garvin, Irimpan I. Mathews, B. Kirtley Amos, Omar Demerdash, Mark Bechthold, Mamta Iyer, Simin Rahighi, Daniel W. Kneller, Andrey Kovalevsky, Stephan Irle, Van-Quan Vuong, Julie C. Mitchell, Audrey Labbe, Stephanie Galanie, Soichi Wakatsuki, Daniel Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors report crystallographic and computational studies that detail how SARS-CoV-2 3CLpro cleaves the host NF-κB Essential Modulator in addition to its canonical viral substrates. The association with the high fitness of SARS-CoV-2 in humans i
Externí odkaz:
https://doaj.org/article/f4a60ed5420947fea700b6dd36aeb82f
Autor:
Daniel W. Kneller, Hui Li, Gwyndalyn Phillips, Kevin L. Weiss, Qiu Zhang, Mark A. Arnould, Colleen B. Jonsson, Surekha Surendranathan, Jyothi Parvathareddy, Matthew P. Blakeley, Leighton Coates, John M. Louis, Peter V. Bonnesen, Andrey Kovalevsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Three covalent hybrid inhibitors of SARS-CoV-2 main protease (Mpro) have been designed and compared to Pfizer’s nirmatrelvir (PF-07321332), providing atomic and thermodynamic details of their binding to the enzyme, and antiviral potency.
Externí odkaz:
https://doaj.org/article/a34b92fdec104f1c9e1eb9363f0311ad
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 973-979 (2021)
SARS-CoV-2 emerged at the end of 2019 to cause an unprecedented pandemic of the deadly respiratory disease COVID-19 that continues to date. The viral main protease (Mpro) is essential for SARS-CoV-2 replication and is therefore an important drug targ
Externí odkaz:
https://doaj.org/article/53704c447e1746098f45e3c77c49f7ca
Publikováno v:
Bioresources and Bioprocessing, Vol 8, Iss 1, Pp 1-12 (2021)
Abstract β-1,3-glucanase can specifically hydrolyze glucans to oligosaccharides and has potential applications in biotechnology. We used the metatranscriptomic technology to discover a thermophilic β-1,3-glucanase from compost. The phylogenetic stu
Externí odkaz:
https://doaj.org/article/d927e06aa37b437eaa0e2e411dcf12c9
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 206-215 (2021)
Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. Human AChE (hAChE) is a target of nerve agent and pesticide organophosphorus compounds that covalently a
Externí odkaz:
https://doaj.org/article/0fdbb2fad6eb4eb6a5ed3166563a6633
Autor:
Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O'Neill, Kemin Tan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky
Publikováno v:
IUCrJ, Vol 7, Iss 6, Pp 1028-1035 (2020)
The emergence of the novel coronavirus SARS-CoV-2 has resulted in a worldwide pandemic not seen in generations. Creating treatments and vaccines to battle COVID-19, the disease caused by the virus, is of paramount importance in order to stop its spre
Externí odkaz:
https://doaj.org/article/6f8288b421504c10acb305f2a86d19ce
Autor:
Steven Dajnowicz, Yongqiang Cheng, Luke L. Daemen, Kevin L. Weiss, Oksana Gerlits, Timothy C. Mueser, Andrey Kovalevsky
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18787-18797 (2020)
Externí odkaz:
https://doaj.org/article/75d8f6851b6948099557ae3396fa3209