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Autor:
Andrey Kechin, Viktoria Borobova, Ulyana Boyarskikh, Evgeniy Khrapov, Sergey Subbotin, Maxim Filipenko
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008468 (2020)
Multiplex polymerase chain reaction (PCR) has multiple applications in molecular biology, including developing new targeted next-generation sequencing (NGS) panels. We present NGS-PrimerPlex, an efficient and versatile command-line application that d
Externí odkaz:
https://doaj.org/article/78a6fc1d623f40cfb563205ab88aea94
Publikováno v:
Applied Sciences, Vol 12, Iss 5, p 2506 (2022)
NTRK gene fusions are drivers of tumorigenesis events that specific Trk-inhibitors can target. Current knowledge of the downstream pathways activated has been previously limited to the pathways of regulator proteins phosphorylated directly by Trk rec
Externí odkaz:
https://doaj.org/article/a5cc03f3768b4238b1441f2ea36392ad
Publikováno v:
Viral Immunology. 35:138-141
There are hundreds of coronaviruses, most of which circulate among animals, yet there are seven types that infect humans. Three of them can cause severe acute respiratory illness-SARS-CoV, SARS-CoV-2, and MERS-CoV. Other HCoV-229E, HCoV-OC43, HCoV-NL
Autor:
Andrey Kechin, Igor Oscorbin, Andrey Cherednichenko, Evgeniy Khrapov, Yakov Schwartz, Nataliya Stavitskaya, Maksim Filipenko
Publikováno v:
Archives of Microbiology. 205
Autor:
Sergey G. Scherbak, Ulyana A. Boyarskikh, Darya Boldyreva, Svetlana V. Apalko, Andrey Kechin, Maxim L. Filipenko, Lidia Kaftyreva, Maria Makarova, Viktoriya Borobova, Nikolay Mosyakin
Publikováno v:
The Journal of Biochemistry. 170:675-681
Next-generation sequencing (NGS)-library preparation for whole-genome sequencing (WGS) starts with DNA fragmentation, and sonication is a physical approach used most often due to its simplicity and reproducibility. However, the commercially available
Autor:
Andrey Kechin, Ulyana Boyarskikh, Alexey Barinov, Alexander Tanas, Svetlana Kazakova, Anastasia Zhevlova, Evgeniy Khrapov, Sergey Subbotin, Olga Mishukova, Tatiana Kekeeva, Irina Demidova, Maxim Filipenko
Publikováno v:
Breast cancer research and treatment. 197(2)
Pathogenic variants (PVs) in BRCA1 and BRCA2 genes are essential biomarkers of an increased breast and ovarian cancer risk and tumor sensitivity to poly ADP ribose polymerase inhibitors. In Russia, eight PVs were thought to be the most common, among
Autor:
T. V. Kekeeva, Svetlana Kazakova, Sergey Subbotin, Maxim L. Filipenko, Evgeniy Khrapov, Olga V. Mishukova, Alexander S Tanas, Ulyana A. Boyarskikh, Andrey Kechin, I. A. Demidova, Anastasia Zhevlova, Alexey Barinov
Pathogenic mutations in BRCA1 and BRCA2 genes are essential biomarkers of an increased breast and ovarian cancer risk and tumor sensitivity to poly ADP ribose (PARP) inhibitors. In many countries, their detection includes patient prescreening with qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd0067de1d9fd9998460d97409ac993
https://doi.org/10.1101/2021.07.22.21260831
https://doi.org/10.1101/2021.07.22.21260831
Autor:
M. A. Dymova, S. P. Grushin, Alexey A. Tishkin, Maksim L. Filipenko, Andrey Kechin, P. K. Dashkovskiy
Publikováno v:
Russian Journal of Genetics. 55:1499-1505
Sheep were one of the first animals to be domesticated. The history of sheep domestication and their widespread distribution dates to about ten thousand years ago, during which sheep exhibit both physical changes and modifications at the genetic leve
Publikováno v:
Breast Cancer Research and Treatment. 178:545-555
Germinal and somatic rearrangements in BRCA1 gene play a significant role in carcinogenesis of breast and ovarian cancer. The present study is dedicated to the development of multiplex droplet digital PCR (ddPCR) assay for detecting large deletions a