Zobrazeno 1 - 10
of 560
pro vyhledávání: '"Andrew. F. Stewart"'
Autor:
Liora S. Katz, Gabriel Brill, Peng Wang, Luca Lambertini, Pili Zhang, Jonathan M. Haldeman, Hongtao Liu, Christopher B. Newgard, Andrew F. Stewart, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Molecular Metabolism, Vol 79, Iss , Pp 101848- (2024)
Objective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate. Glucose is a natural β-cell mi
Externí odkaz:
https://doaj.org/article/ca3bb72876334491840e4095754b390d
Autor:
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcia-Ocana, Geming Lu
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility
Externí odkaz:
https://doaj.org/article/16b1eb06924e409ea8786e29877b0d8e
Autor:
Radoslav Savić, Jialiang Yang, Simon Koplev, Mahru C. An, Priyanka L. Patel, Robert N. O’Brien, Brittany N. Dubose, Tetyana Dodatko, Eduard Rogatsky, Katyayani Sukhavasi, Raili Ermel, Arno Ruusalepp, Sander M. Houten, Jason C. Kovacic, Andrew F. Stewart, Christopher B. Yohn, Eric E. Schadt, Remi-Martin Laberge, Johan L.M. Björkegren, Zhidong Tu, Carmen Argmann
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113371- (2023)
Summary: Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcripto
Externí odkaz:
https://doaj.org/article/1c20f6d542d54b86acc9526737df22b2
Autor:
Liora S. Katz, Gabriel Brill, Pili Zhang, Anil Kumar, Sharon Baumel-Alterzon, Lee B. Honig, Nicolás Gómez-Banoy, Esra Karakose, Marius Tanase, Ludivine Doridot, Alexandra Alvarsson, Bennett Davenport, Peng Wang, Luca Lambertini, Sarah A. Stanley, Dirk Homann, Andrew F. Stewart, James C. Lo, Mark A. Herman, Adolfo Garcia-Ocaña, Donald K. Scott
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
ChREBP is a glucose-responsive transcription factor, which regulates glucose-mediated proliferation and cell death in pancreatic β-cells. Here the authors show that the acute feed forward induction of ChREBPβ is required for adaptive β-cell expans
Externí odkaz:
https://doaj.org/article/f2c908c5343543e98a1a127b3ec55963
Autor:
Ridgway, Brunilde Sismondo
Publikováno v:
The Classical Outlook, 1980 May 01. 57(5), 114-115.
Externí odkaz:
https://www.jstor.org/stable/43934180
Autor:
Stupperich, Reinhard
Publikováno v:
Gnomon, 1980 Jan 01. 52(3), 280-284.
Externí odkaz:
https://www.jstor.org/stable/27687506
Autor:
Chamoux, F.
Publikováno v:
Revue des Études Grecques, 1979 Jul 01. 92(438/439), 564-565.
Externí odkaz:
https://www.jstor.org/stable/44262434
Autor:
Peng Wang, Esra Karakose, Carmen Argmann, Huan Wang, Metodi Balev, Rachel I. Brody, Hembly G. Rivas, Xinyue Liu, Olivia Wood, Hongtao Liu, Lauryn Choleva, Dan Hasson, Emily Bernstein, Joao A. Paulo, Donald K. Scott, Luca Lambertini, James A. DeCaprio, Andrew F. Stewart
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase DYRK1A have proven effective in inducing adult human β cells to prolifer
Externí odkaz:
https://doaj.org/article/d63ba477fc65456b990c8a7587bff961
Autor:
Clack, Jerry
Publikováno v:
The Classical World, 1997 Jul 01. 90(6), 468-468.
Externí odkaz:
https://www.jstor.org/stable/4352028
Autor:
Esra Karakose, Huan Wang, William Inabnet, Rajesh V. Thakker, Steven Libutti, Gustavo Fernandez-Ranvier, Hyunsuk Suh, Mark Stevenson, Yayoi Kinoshita, Michael Donovan, Yevgeniy Antipin, Yan Li, Xiaoxiao Liu, Fulai Jin, Peng Wang, Andrew Uzilov, Carmen Argmann, Eric E. Schadt, Andrew F. Stewart, Donald K. Scott, Luca Lambertini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Insulinomas are rare, benign beta cell tumours which overproduce insulin and have been associated to epigenetic alterations. Here the authors characterise insulinoma methylomes, finding changes in promoter methylation and chromatin structure proposed
Externí odkaz:
https://doaj.org/article/1d219e060ef14af69f480f879ef60196