Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andrew Yau-Chik Shum"'
Publikováno v:
Journal of Neuroscience Research. 72:508-519
Oxidative stress in the brain has been increasingly associated with the development of numerous human neurological diseases. Microglia, activated upon neuronal injury or inflammatory stimulation, are known to release superoxide anion (*O(2) (-)), hyd
Publikováno v:
Neuroscience Letters. 322:187-191
Hypoxia/reoxygenation (H/R) causes cell injury/death. We examined the protection by drugs intervening at various stages of the injury cascade in cultured neurons and glia. Primary cultures of rat cortical neurons and mixed glia were subjected to H/R.
Publikováno v:
Glia. 32:155-164
Polymorphonuclear neutrophils (PMNs) are known to mediate brain inflammation following hypoxia/reoxygenation (H/R), but the precise mechanisms leading to PMN recruitment are undefined. The alpha-chemokine macrophage inflammatory protein-2 (MIP-2) has
Publikováno v:
Life Sciences. 66:363-370
A system consisting of a hepato-duodenal shunt in which the bile of a drug-treated donor rat was diverted to the duodenum of an untreated recipient rat via a bile cannula was used to assess the role of hepatic metabolism and enterohepatic circulation
Autor:
Andrew Yau Chik Shum, Jiann Jong Chen, Victor S. Fang, Shiow-Chwen Tsai, Paulus S. Wang, Jiun Yih Yeh, Shyi-Wu Wang, Yu Chung Chiao, Mei Mei Kau, Low-Tone Ho, Ho Lin, Ming Jae Lo
Publikováno v:
Metabolism. 48:1108-1114
In vivo and in vitro experiments were designed to assess the effect of testosterone on aldosterone secretion in male rats. Orchidectomized rats were injected subcutaneously with oil or testosterone propionate ([TP] 2 mg/kg) for 7 days. Intact rats we
Publikováno v:
Journal of Natural Products. 60:708-711
Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their effects on NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 and 2 inhibited the IFN-gamma
Publikováno v:
Journal of Cardiovascular Pharmacology. 29:490-498
We conducted studies to investigate the nature and underlying mechanisms of the vascular effects of rutaecarpine (Rut), an alkaloid isolated from the Chinese herbal drug Evodia rutaecarpa. By using largely the effects on phenylephrine (PE)-induced co
Publikováno v:
Alcoholism: Clinical and Experimental Research. 20:1252-1259
The relationship between central serotonergic activities and voluntary alcohol consumption was studied in Sprague-Dawley rats, which normally have low alcohol preference. After initial screening for an evenly matched baseline alcohol preference, sele
Publikováno v:
Journal of Cardiovascular Pharmacology. 27:845-853
We examined the mechanisms underlying the vasorelaxant effect of dehydroevodiamine (DeHE), one of the bioactive components of the Chinese herbal drug Evodia rutaecarpa that has been shown to produce vasorelaxant and hypotension. DeHE (10(-7)-10(-4) M
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 617:87-93
A high-performance liquid chromatographic method has been developed for the determination of dehydroevodiamine (DeHE), an active principle from Evodia fruit. Plasma was denatured with acetonitrile and centrifuged, the supernatant was separated and bl