Effects of non-coding RNAs and RNA-binding proteins on mitochondrial dysfunction in diabetic cardiomyopathy

Autor: Koray N. Potel, Victoria A. Cornelius, Andrew Yacoub, Ali Chokr, Clare L. Donaghy, Sophia Kelaini, Magdalini Eleftheriadou, Andriana Margariti

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

Vascular complications are the main cause of diabetes mellitus-associated morbidity and mortality. Oxidative stress and metabolic dysfunction underly injury to the vascular endothelium and myocardium, resulting in diabetic angiopathy and cardiomyopat

Externí odkaz: https://doaj.org/article/ce4c32075e824d97aaf0a55ac12862a1

Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Autor: Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/0052053883264ab39db9bf4a7efba1c7

9 Induced pluripotent stem cell-derived endothelial cells from human diabetic donors carry an imprint of the diabetic milieu

Autor: Victoria A. Cornelius, Martha Gonzalez, Garret Carney, Andriana Margariti, Sophia Kelaini, Hojjat Naderi Meskin, Guillermo Lopez Campos, Alan W. Stitt, Thomas Morrison, Andrew Yacoub, Chunbo Yang, Noemi Lois, David J. Grieve, Magdalini Eleftheriadou

Publikováno v: ACHD/Valve disease/Pericardial disease/Cardiomyopathy.

Diabetic endotheliopathy is the main cause for impaired angiogenesis and reduced neovascularization that lead to microvascular injury and vascular complications. The pathogenic basis for vascular complications arising from diabetes is complex. Elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c0acc1cbaac7e9366d9cddfe26b5e4f
https://doi.org/10.1136/heartjnl-2021-bcs.9

Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Autor: Kevin S Edgar, David J. Grieve, Fiona L. Wilkinson, Marta Vilà González, Aleksandar Ivetic, Chunbo Yang, Thomas Morrison, Andrew Yacoub, Alan W. Stitt, Andriana Margariti, Arya Moez, Sophia Kelaini, Lingfang Zeng, Nicola C. Edwards, Rachel Caines, Magdalini Eleftheriadou, Noemi Lois, Anna Zampetaki

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Yang, C, Eleftheriadou, M, Kelaini, S, Morrison, T, González, M V, Caines, R, Edwards, N, Yacoub, A, Edgar, K, Moez, A, Ivetic, A, Zampetaki, A, Zeng, L, Wilkinson, F L, Lois, N, Stitt, A W, Grieve, D J & Margariti, A 2020, ' Targeting QKI-7 in vivo restores endothelial cell function in diabetes ', Nature Communications, vol. 11, no. 1, 3812 . https://doi.org/10.1038/s41467-020-17468-y
Nature Communications

Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d63bd09de83a23024811829eb558c7
https://doi.org/10.1038/s41467-020-17468-y

British Cardiovascular Society Annual Conference, ‘Future-proofing Cardiology for the next 10 years’, 5–7 June 2023.

Publikováno v: Heart; 2023 Supplement, Vol. 109, pA1-A316, 316p