Výsledky vyhledávání - "Andrew Y F Li Yim"

Akademický článek

A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients.

Autor: Andrew Y F Li Yim, Jessica R de Bruyn, Nicolette W Duijvis, Catriona Sharp, Enrico Ferrero, Wouter J de Jonge, Manon E Wildenberg, Marcel M A M Mannens, Christianne J Buskens, Geert R D'Haens, Peter Henneman, Anje A Te Velde

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0209656 (2018)

BackgroundThe chronic remitting and relapsing intestinal inflammation characteristic of Crohn's disease frequently leads to fibrosis and subsequent stenosis of the inflamed region. Approximately a third of all Crohn's disease patients require resecti

Externí odkaz: https://doaj.org/article/4d247c38076e4a7984fa3ae11f10c912

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Electrical stimulation of the splenic nerve bundle ameliorates dextran sulfate sodium-induced colitis in mice

Autor: David J. Brinkman, Thomas Simon, Anne S. ten Hove, Konstantina Zafeiropoulou, Olaf Welting, Patricia H. P. van Hamersveld, Rose A. Willemze, Andrew Y. F. Li Yim, Caroline Verseijden, Theodorus B. M. Hakvoort, Misha D. Luyer, Margriet J. Vervoordeldonk, Philippe Blancou, Wouter J. de Jonge

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)

Abstract Background Vagus nerve stimulation has been suggested to affect immune responses, partly through a neuronal circuit requiring sympathetic innervation of the splenic nerve bundle and norepinephrine (NE) release. Molecular and cellular mechani

Externí odkaz: https://doaj.org/article/ac39e9f6ad244b79956b6fb3b089e2cd

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis

Autor: Manon de Krijger, Ishtu L. Hageman, Andrew Y. F. Li Yim, Jan Verhoeff, Juan J. Garcia Vallejo, Patricia H. P. van Hamersveld, Evgeni Levin, Theodorus B. M. Hakvoort, Manon E. Wildenberg, Peter Henneman, Cyriel Y. Ponsioen, Wouter J. de Jonge

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundPrimary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease affecting the intra- and extrahepatic bile ducts, and is strongly associated with ulcerative colitis (UC). In this study, we explored the peripheral blood DNA meth

Externí odkaz: https://doaj.org/article/ecb2a98c38e74c07ac01f6e645bbf90b

Zobrazit plný text záznamu

Akademický článek

The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia

Autor: Anne S. ten Hove, David J. Brinkman, Andrew Y. F. Li Yim, Caroline Verseijden, Theo B. M. Hakvoort, Iris Admiraal, Olaf Welting, Patricia H. P. van Hamersveld, Valérie Sinniger, Bruno Bonaz, Misha D. Luyer, Wouter J. de Jonge

Publikováno v: Bioelectronic Medicine, Vol 6, Iss 1, Pp 1-9 (2020)

Abstract Background Recent evidence demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagates in intestinal epithelial cells expressing Angiotensin-Converting Enzyme 2 (ACE2), implying that these cells represent an imp

Externí odkaz: https://doaj.org/article/8da687ffb5414ed9827d945dc5060872

Zobrazit plný text záznamu

Akademický článek

HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

Autor: Mohammed Ghiboub, Jing Zhao, Andrew Y. F. Li Yim, Ronald Schilderink, Caroline Verseijden, Patricia H. P. van Hamersveld, Jose M. Duarte, Theodorus B. M. Hakvoort, Iris Admiraal, Nicola R. Harker, David F. Tough, Peter Henneman, Menno P. J. de Winther, Wouter J. de Jonge

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Histone deacetylases (HDACs) are a group of enzymes that control histone deacetylation and bear potential to direct expression of large gene sets. We determined the effect of HDAC inhibitors (HDACi) on human monocytes and macrophages, with respect to

Externí odkaz: https://doaj.org/article/a74ef761dc23407aa1f2acb610c86280

Zobrazit plný text záznamu

Akademický článek

Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo

Autor: Hung-Jen Chen, Andrew Y. F. Li Yim, Guillermo R. Griffith, Wouter J. de Jonge, Marcel M. A. M. Mannens, Enrico Ferrero, Peter Henneman, Menno P. J. de Winther

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acqui

Externí odkaz: https://doaj.org/article/69445752fbed41219738ad83a50db440

Zobrazit plný text záznamu

Expression Quantitative Trait Methylation Analysis Identifies Whole Blood Molecular Footprint in Fetal Alcohol Spectrum Disorder (FASD)

Autor: Izabela M. Krzyzewska, Peter Lauffer, Adri N. Mul, Liselot van der Laan, Andrew Y. F. Li Yim, Jan Maarten Cobben, Jacek Niklinski, Monika A. Chomczyk, Robert Smigiel, Marcel M. A. M. Mannens, Peter Henneman

Publikováno v: International Journal of Molecular Sciences, 24(7):6601. Multidisciplinary Digital Publishing Institute (MDPI)
Krzyzewska, I M, Lauffer, P, Mul, A N, van der Laan, L, Yim, A Y F L, Cobben, J M, Niklinski, J, Chomczyk, M A, Smigiel, R, Mannens, M M A M & Henneman, P 2023, ' Expression Quantitative Trait Methylation Analysis Identifies Whole Blood Molecular Footprint in Fetal Alcohol Spectrum Disorder (FASD) ', International Journal of Molecular Sciences, vol. 24, no. 7, 6601 . https://doi.org/10.3390/ijms24076601
International journal of molecular sciences, 24(7):6601. Multidisciplinary Digital Publishing Institute (MDPI)

Fetal alcohol spectrum disorder (FASD) encompasses neurodevelopmental disabilities and physical birth defects associated with prenatal alcohol exposure. Previously, we attempted to identify epigenetic biomarkers for FASD by investigating the genome-w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d666b71d03d544c0bdf3cfba34cfa87
https://research.vumc.nl/en/publications/0aacc1c0-b827-42f3-8855-2c5a87f700f1

Zobrazit plný text záznamu

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease

Publikováno v: Elfiky, A M I, Ghiboub, M, Li Yim, A Y F, Hageman, I L, Verhoeff, J, de Krijger, M, van Hamersveld, P H P, Welting, O, Admiraal, I, Rahman, S, Garcia-Vallejo, J J, Wildenberg, M E, Tomlinson, L, Gregory, R, Rioja, I, Prinjha, R K, Furze, R C, Lewis, H D, Mander, P K, Heinsbroek, S E M, Bell, M J & de Jonge, W J 2022, ' Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease ', Journal of Crohn's and Colitis, vol. 16, no. 4, pp. 668-681 . https://doi.org/10.1093/ecco-jcc/jjab176
Journal of Crohn's and Colitis, 16(4), 668-681. Elsevier
Journal of Crohn's & colitis, 16(4), 668-681. Elsevier

Background and AimsHistone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression of HDACs, clinical utility of HDACi is limited by off-target effects. Esterase-sensitive motif [ESM] technology aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c0316620861e7964614f67286a50a
https://doi.org/10.1093/ecco-jcc/jjab176

Zobrazit plný text záznamu

Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn's Disease Patients

Autor: Vincent W. Joustra, Andrew Y. F. Li Yim, Jessica R. de Bruyn, Marjolijn Duijvestein, Ishtu L. Hageman, Wouter J. de Jonge, Peter Henneman, Manon Wildenberg, Geert D’Haens

Publikováno v: International journal of molecular sciences, 23(18):10467. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10467
International Journal of Molecular Sciences, 23
International Journal of Molecular Sciences, 23, 18

Prediction of endoscopic post-operative recurrence (POR) in Crohn’s disease (CD) patients following ileocolonic resection (ICR) using clinical risk factors alone has thus far been inadequate. While peripheral blood leukocyte (PBL) DNA methylation h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e83d5d0dfda187e2be107573e1db27
https://pure.amc.nl/en/publications/peripheral-blood-dna-methylation-profiles-do-not-predict-endoscopic-postoperative-recurrence-in-crohns-disease-patients(d256de81-d76a-4a49-b686-612145179a17).html

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání