Direct Oral Anticoagulants Versus Warfarin in the Treatment of Left Ventricular Thrombus

Autor: Wenhong Zhu, Andrew Willeford, Craig A. Stevens, Isac C. Thomas

Publikováno v: Ann Pharmacother

Background Use of direct oral anticoagulants (DOACs) for the treatment of left ventricular (LV) thrombus has gained considerable interest. Objective We aimed to evaluate if DOACs are effective in the treatment of LV thrombus compared with warfarin. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef420960ed3fa930d3d7130ce89a2500
https://pubmed.ncbi.nlm.nih.gov/33191781

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

Autor: Robert S. Ross, Yoshitake Cho, Shigeki Miyamoto, Andrew Willeford, Joan Heller Brown, Cameron S. Brand, Takeshi Suetomi

Publikováno v: Circulation. 138:2530-2544

Background: Inflammation is associated with cardiac remodeling and heart failure, but how it is initiated in response to nonischemic interventions in the absence of cell death is not known. We tested the hypothesis that activation of Ca 2+ /calmoduli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39b349f93c56d97cf1d7ad31becf888c
https://doi.org/10.1161/circulationaha.118.034621

CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis

Autor: Shigeki Miyamoto, Hal M. Hoffman, Andrew Willeford, Audrey Nickle, Joan Heller Brown, Takeshi Suetomi

Publikováno v: Willeford, A; Suetomi, T; Nickle, A; Hoffman, HM; Miyamoto, S; & Heller Brown, J. (2018). CaMKIIδ-mediated inflammatory gene expression and inflammasome activation in cardiomyocytes initiate inflammation and induce fibrosis. JCI Insight, 3(12). doi: 10.1172/jci.insight.97054. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/39g1c6h8
JCI insight, vol 3, iss 12

Inflammation accompanies heart failure and is a mediator of cardiac fibrosis. CaMKIIδ plays an essential role in adverse remodeling and decompensation to heart failure. We postulated that inflammation is the mechanism by which CaMKIIδ contributes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d73cda213162c9acd726be6dd1e70c
http://www.escholarship.org/uc/item/39g1c6h8

Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice

Autor: Prabhleen Singh, Andrew Willeford, Mark Hepokoski, Joan Heller Brown, Laura E. Crotty Alexander, Jiang Tian, Zachary Yong, Ashley Du, John Shin, Christopher A. Drummond, A. Moshensky, Christian Javier, Denzil P. Mathew, Jasmine Lee, Kevin Vega, Ellen C. Breen, Soumita Das

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology, vol 314, iss 6
Am J Physiol Regul Integr Comp Physiol
Alexander, LEC; Drummond, CA; Hepokoski, M; Mathew, D; Moshensky, A; Willeford, A; et al.(2018). Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 314(6), R834-R847. doi: 10.1152/ajpregu.00270.2017. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3cj3r0h3

Electronic (e)-cigarettes theoretically may be safer than conventional tobacco. However, our prior studies demonstrated direct adverse effects of e-cigarette vapor (EV) on airway cells, including decreased viability and function. We hypothesize that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078c6dc4010ca8feacc1dfa1616bb1f
https://europepmc.org/articles/PMC6032308/

Abstract 160: Cardiomyocyte CaMKII Mediates Expression of Pro-inflammatory Chemokines and Cytokines, Macrophage Infiltration and Cardiac Remodeling in Response to Pressure Overload

Autor: Takeshi Suetomi, Andrew Willeford, Shigeki Miyamoto, Joan Heller Brown

Publikováno v: Circulation Research. 121

Background: There is evidence that inflammation is associated with pressure overload induced cardiac remodeling and heart failure, as well as evidence for a role of CaMKII in remodeling and heart failure development. Whether CaMKII mediates inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c164a127194f89ecde0eea1f7d3ac69
https://doi.org/10.1161/res.121.suppl_1.160