Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Andrew Wigg"'
Autor:
Alan A. Schmalstig, Andrew Wiggins, Debbie Badillo, Katherine S. Wetzel, Graham F. Hatfull, Miriam Braunstein
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTMycobacterium abscessus is a nontuberculous mycobacteria that contributes to the decline and death of patients with lung diseases such as cystic fibrosis and other muco-obstructive airway diseases. M. abscessus is challenging to treat due to
Externí odkaz:
https://doaj.org/article/915f8cf78b3040a99a224a9cb2f79e09
Autor:
David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto
Publikováno v:
Journal of Medicinal Chemistry. 52:3523-3538
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180003a136c55f74b0ef18c43fb4d04e
https://doi.org/10.1021/jm801394m
https://doi.org/10.1021/jm801394m
Publikováno v:
Protein Science. 7:2033-2037
The lysosomal cysteine protease cathepsin B has been studied intensely for many years because of its unique characteristics and its potential involvement in disease states. A reproducible, high yield expression system for active recombinant protein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324dd40d2779becaaa8a300f16543753
https://doi.org/10.1002/pro.5560070920
https://doi.org/10.1002/pro.5560070920
Autor:
Rosanna Fox, Zeshan Saeed, Sadia Khan, Harry Robertson, Sophie Crisford, Andrew Wiggam, Abby Foley, Farhana Raza, Michael Wright
Publikováno v:
PLOS Digital Health, Vol 1, Iss 11, p e0000146 (2022)
The factors associated with digital exclusion in the covid virtual ward population at a North West London teaching hospital were assessed in this study. Patients discharged from the covid virtual ward were contacted to give their feedback on their ex
Externí odkaz:
https://doaj.org/article/d2a8b93d618c4dfc9f00a1ed906ea3de
Autor:
David Farley, J. R. Doughty, Scott Douglas Cowen, Elizabeth Quadros, Tommasi Ruben A, Leslie Wighton Mcquire, Andrew Wigg, Huanghai Zhou, Karen Toscano, David E. Coppa, Zheng Fang, Zengming Du, Siyuan Zhou, Paul D. Greenspan, Kirk Clark
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(22)
To improve the pharmacokinetics of a previously reported series of dipeptidyl nitrile cathepsin B inhibitors, the P(2)-P(3) amide group was replaced with an arylamine. Further optimization of this template resulted in highly potent and selective inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9de6f4ecbe4a0a2dc19f84332d97ae
https://pubmed.ncbi.nlm.nih.gov/14592520
https://pubmed.ncbi.nlm.nih.gov/14592520
Autor:
Kirk Clark, Regine Bohacek, Andrew Wigg, Robert Goldstein, Z. Fang, J. R. Doughty, John Fitt, Leslie Wighton Mcquire, Michael Paul Capparelli, David Farley, Zhengming Du, Ronald L. Goldberg, Anna K. Knap, Scott Douglas Cowen, Paul D. Greenspan, William Macchia, David E. Coppa, J. H. van Duzer, Tommasi Ruben A, Lijuan Zhu, Huanghai Zhou
Publikováno v:
Journal of medicinal chemistry. 44(26)
Cathepsin B is a member of the papain superfamily of cysteine proteases and has been implicated in the pathology of numerous diseases, including arthritis and cancer. As part of an effort to identify potent, reversible inhibitors of this protease, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cd9702d74ca2af2d4b39b2c718d403
https://pubmed.ncbi.nlm.nih.gov/11741472
https://pubmed.ncbi.nlm.nih.gov/11741472