Výsledky vyhledávání - "Andrew Whitney"

Akademický článek

An augmented and interactive exhibition of an archived model for Frederick Kiesler's Endless House, 1959

Autor: Chantelle Niblock, Laura McGuire, John Harding, Gerd Zillner, Chris Hamill, Andrew Whitney

Publikováno v: Frontiers of Architectural Research, Vol 11, Iss 6, Pp 993-1006 (2022)

This research explores the potential of an immersive and interactive online archive to enhance our understanding of historic architecture through the study of models. It reports on implementing an augmented reality mobile application that exhibits a

Externí odkaz: https://doaj.org/article/499f4fb0cbc343af9a1317c9135e5680

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Akademický článek

Thermal stabilization of dihydrofolate reductase using monte carlo unfolding simulations and its functional consequences.

Autor: Jian Tian, Jaie C Woodard, Andrew Whitney, Eugene I Shakhnovich

Publikováno v: PLoS Computational Biology, Vol 11, Iss 4, p e1004207 (2015)

Design of proteins with desired thermal properties is important for scientific and biotechnological applications. Here we developed a theoretical approach to predict the effect of mutations on protein stability from non-equilibrium unfolding simulati

Externí odkaz: https://doaj.org/article/0de565c5f8ba4e83acf0d1ba075a7893

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Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite—Resolution for Clinical Development

Autor: Jim Zheng, Matthew Robert Warr, Bill J. Smith, Lisa Moorehead, Bernard P. Murray, Jeffrey A. Silverman, John Ling, Raju Subramanian, Jingyu Zhang, Yan Xin, Ellen Kwan, J. Andrew Whitney, Hemenway Jeffrey N

Publikováno v: Drug Metabolism and Disposition. 46:237-247

Momelotinib (MMB), a small-molecule inhibitor of Janus kinase (JAK)1/2 and of activin A receptor type 1 (ACVR1), is in clinical development for the treatment of myeloproliferative neoplasms. The pharmacokinetics and disposition of [14C]MMB were chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ca91bf722b61fe9a2e7b79eeb79385
https://doi.org/10.1124/dmd.117.078899

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Akademický článek

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Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase

Autor: J. Andrew Whitney, Kevin S. Currie, Deborah Maclin, James Barbosa, Kropf Jeffrey E, Ann Marie Rossi, Eric B. Lansdon, Jennifer Macaluso, Scott A. Mitchell, Hong Rong, Tony Lee, Jianjun Xu, Steve Gallion, Patricia Maciejewski, Julie Di Paolo, Peter A. Blomgren, Zhongdong Zhao

Publikováno v: Journal of Medicinal Chemistry. 57:3856-3873

Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form fostamatinib, 2), has shown efficacy in multiple therapeutic indica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b4e26bd97c65595d3ff3afda0fbb23
https://doi.org/10.1021/jm500228a

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Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents

Autor: Malte, Asshoff, Verena, Petzer, Matthew R, Warr, David, Haschka, Piotr, Tymoszuk, Egon, Demetz, Markus, Seifert, Wilfried, Posch, Manfred, Nairz, Pat, Maciejewski, Peter, Fowles, Christopher J, Burns, Gregg, Smith, Kay-Uwe, Wagner, Guenter, Weiss, J Andrew, Whitney, Igor, Theurl

Publikováno v: Blood. 129(13)

Patients with myelofibrosis (MF) often develop anemia and frequently become dependent on red blood cell transfusions. Results from a phase 2 study for the treatment of MF with the Janus kinase 1/2 (JAK1/2) inhibitor momelotinib (MMB) demonstrated tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9838e64baf38c131b5e8054e2d77664b
https://pubmed.ncbi.nlm.nih.gov/28188131

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Interaction of 2,4-Diaminopyrimidine-Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters

Autor: Xiaomin Liang, Jolyn Twelves, Jayaraman Chandrasekhar, J. Andrew Whitney, Marilyn M. Giacomini, Jia Hao, Eve-Irene Lepist, Adrian S. Ray

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 45(1)

Inhibition of thiamine transporters has been proposed as a putative mechanism for the observation of Wernicke's encephalopathy and subsequent termination of clinical development of fedratinib, a Janus kinase inhibitor (JAKi). This study aimed to dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cf1dad0d4682ea5272c01e1dc7a127
https://pubmed.ncbi.nlm.nih.gov/28974558

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Chemical Genetic Transcriptional Fingerprinting for Selectivity Profiling of Kinase Inhibitors

Autor: Kevin S. Currie, J. Andrew Whitney, Julie DiPaolo, Tarif Awad, Shan Jiang, Dapeng Qian, Arun Ramamurthy, Mark Velleca, Johnny Peppers, Scott Alderucci, Xiaobing Qian

Publikováno v: ASSAY and Drug Development Technologies. 5:49-64

The importance of protein kinases as a major class of drug targets across multiple diseases has generated a critical need for technologies that enable the identification of potent and selective kinase inhibitors. Bruton's tyrosine kinase (Btk) is a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238c9246f2d8807b40ffe7b82e37ca21
https://doi.org/10.1089/adt.2006.032

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Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials

Publikováno v: Neuro-Oncology, 17(9), 1188-1198. Oxford University Press

A recent joint meeting was held on January 30, 2014, with the US Food and Drug Administration (FDA), National Cancer Institute (NCI), clinical scientists, imaging experts, pharmaceutical and biotech companies, clinical trials cooperative groups, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fcf5c8942bda280fc10cab265b0ed1
https://doi.org/10.1093/neuonc/nov095

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Reference Systems for Kinase Drug Discovery: Chemical Genetic Approaches to Cell-Based Assays

Autor: J. Andrew Whitney

Publikováno v: ASSAY and Drug Development Technologies. 2:417-430

Protein kinases play key roles in a number of diseases, including cancer, inflammation, and diabetes. Disregulation of kinase-based signal transduction networks results in aberrant cell differentiation, activation, proliferation, and invasion. The gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a803777b5fc7d5aef532da9f7405e3a6
https://doi.org/10.1089/adt.2004.2.417

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