Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andrew Weiskopf"'
Publikováno v:
Journal of the American Society for Mass Spectrometry. 27:669-676
When highly concentrated, an antibody solution can exhibit unusual behaviors, which can lead to unwanted properties, such as increased levels of protein aggregation and unusually high viscosity. Molecular modeling, along with many indirect biophysica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506f75b4f3d94743894036cf8d55fcd1
https://doi.org/10.1007/s13361-015-1331-7
https://doi.org/10.1007/s13361-015-1331-7
Publikováno v:
Journal of Pharmaceutical Sciences. 104:3984-3989
Protein self-association or aggregation is a property of significant concern for biopharmaceutical products due to the potential ability of aggregates to cause adverse toxicological and immunological effects. Thus, during the development of a protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028601b6d2b3619239040d8fad558f5e
https://doi.org/10.1002/jps.24616
https://doi.org/10.1002/jps.24616
Autor:
Caroline Ceailles, Flarakos, Andrew, Weiskopf, Matthew, Robinson, Guoshun, Wang, Paul, Vouros, Gino J, Sasso, Milan R, Uskokovic, G Satyanarayana, Reddy
Publikováno v:
Steroids. 119
Analogs of 1α,25-dihydroxyvitamin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e1e873c10ffe8b55a14f672d4e9e7bc
https://pubmed.ncbi.nlm.nih.gov/28089927
https://pubmed.ncbi.nlm.nih.gov/28089927
Autor:
Damian Houde, George M. Bou-Assaf, Marco van de Weert, Zeinab E. Nazari, Andrew Weiskopf, Kasper D. Rand
Publikováno v:
Journal of pharmaceutical sciences. 105(11)
Hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS) has become an established method for analysis of protein higher order structure. Here, we use HDX-MS methodology based on manual solid-phase extraction (SPE) to allow fast and simplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfc57fc536dd29a0893c0f2de003375
https://pubmed.ncbi.nlm.nih.gov/27578543
https://pubmed.ncbi.nlm.nih.gov/27578543
Autor:
Paolo Mangiagalli, Thomas Spitznagel, Michael Rosario Defelippis, Andrew Weiskopf, Bernardo Perez-Ramirez, Hanns-Christian Mahler, Douglas P. Nesta, Atanas Koulov, Patrick Garidel, Robert Simler, Klaus Wuchner, Irene Cecchini, Patricia W. Cash, Vincent Corvari, Linda O. Narhi, Mara Rossi, Roland Schmidt, Shawn Cao, Tony Lubiniecki, Alla Polozova, Andrea Herre, Satish K. Singh, Nataliya Afonina
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 43(6)
Measurement and characterization of subvisible particles (including proteinaceous and non-proteinaceous particulate matter) is an important aspect of the pharmaceutical development process for biotherapeutics. Health authorities have increased expect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89c37a0d1aa6d59cdd007e49c1292dd
https://pubmed.ncbi.nlm.nih.gov/26324466
https://pubmed.ncbi.nlm.nih.gov/26324466
Autor:
Irene Cecchini, Paolo Mangiagalli, Robert Simler, Hanns-Christian Mahler, Douglas P. Nesta, Patrick Garidel, Dean C. Ripple, Atanas Koulov, Mara Rossi, Bernardo Perez-Ramirez, Satish K. Singh, Thomas Spitznagel, Alla Polozova, Andrew Weiskopf, Nataliya Afonina, Linda O. Narhi, Andrea Herre, Roland Schmidt, Tony Lubiniecki, Vincent Corvari, Michael Rosario Defelippis, Klaus Wuchner
Publikováno v:
Journal of pharmaceutical sciences. 104(6)
Measurement and characterization of subvisible particles (defined here as those ranging in size from 2 to 100 μm), including proteinaceous and nonproteinaceous particles, is an important part of every stage of protein therapeutic development. The to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6a430a97abb4eefc995724dcc7607c
https://pubmed.ncbi.nlm.nih.gov/25832583
https://pubmed.ncbi.nlm.nih.gov/25832583
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 960
Size-exclusion chromatography (SEC) is commonly used to monitor low molecular weight fragments and aggregates present in recombinant monoclonal antibody (mAb) biopharmaceuticals. It has been previously demonstrated that SEC could be coupled with mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2fad8fd2f38c49d8363a7284b7f20e
https://pubmed.ncbi.nlm.nih.gov/24835510
https://pubmed.ncbi.nlm.nih.gov/24835510
Autor:
Pierceall William, Erin L. Mullady, William Millett, Dallas Hughes, Dennis Ditullio, Jianxin Chen, Victoria Knight-Connoni, Andrew Weiskopf, Hye-Dong Yoo
Publikováno v:
Journal of natural products. 67(12)
A screening campaign was implemented utilizing capillary electrophoresis as a primary assay to discover binders to the cancer target Akt1 from a crude natural extract library. Fungal extracts with binding activities were characterized for biochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62da8bb394c4ef0ec24f9a3d730d4fe1
https://pubmed.ncbi.nlm.nih.gov/15620258
https://pubmed.ncbi.nlm.nih.gov/15620258