Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Andrew W. Truman"'
Autor:
Alaster D. Moffat, Lars Höing, Javier Santos-Aberturas, Tim Markwalder, Jacob G. Malone, Robin Teufel, Andrew W. Truman
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The genus Pseudomonas is a prolific source of specialized metabolites with significant biological activities, including siderophores, antibiotics, and plant hormones. These molecules play pivotal roles in environmental interactions, influenc
Externí odkaz:
https://doaj.org/article/673fc1d37a644b1dab6318c14f2291d4
Autor:
Yuka Okusha, Martin E. Guerrero-Gimenez, Benjamin J. Lang, Thiago J. Borges, Mary A. Stevenson, Andrew W. Truman, Stuart K. Calderwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The dynamic network of chaperone interactions known as the chaperome contributes significantly to the proteotoxic cell response and the malignant phenotype. To bypass the inherent redundancy in the network, we have used a microRNA (mir) appr
Externí odkaz:
https://doaj.org/article/08c5c3ecf3294ec38e46e5dccd87122b
Autor:
Justin A. Davis, Andres V. Reyes, Nitika, Arpita Saha, Donald J. Wolfgeher, Shou-Ling Xu, Andrew W. Truman, Bibo Li, Kausik Chakrabarti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which p
Externí odkaz:
https://doaj.org/article/8b242566a6fc46348656b995a5720a6e
Autor:
Alicia H. Russell, Andrew W. Truman
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1838-1851 (2020)
Genome mining is a computational method for the automatic detection and annotation of biosynthetic gene clusters (BGCs) from genomic data. This approach has been increasingly utilised in natural product (NP) discovery due to the large amount of seque
Externí odkaz:
https://doaj.org/article/5b4834da3f96450c84c8b96ef4a903fd
Autor:
Natalia Ricco, Amy Flor, Don Wolfgeher, Elena V. Efimova, Aishwarya Ramamurthy, Oliver K. Appelbe, Jacqueline Brinkman, Andrew W. Truman, Michael T. Spiotto, Stephen J. Kron
Publikováno v:
Molecular Oncology, Vol 13, Iss 9, Pp 1927-1943 (2019)
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors (statins) may overcome resistance. Proteomic
Externí odkaz:
https://doaj.org/article/c9b43aab1c114bd4b7546f87f2756ce4
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 864 (2022)
Molecular chaperones such as Hsp70 and Hsp90 help fold and activate proteins in important signal transduction pathways that include DNA damage response (DDR). Previous studies have suggested that the levels of the mammalian APE2 exonuclease, a protei
Externí odkaz:
https://doaj.org/article/e5fc1fdeed1941f3ac2fb2a6a48dd9d8
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Bottromycin is a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by several streptomycetes, including the plant pathogen Streptomyces scabies. There is significant interest in this molecule as it possesses strong ant
Externí odkaz:
https://doaj.org/article/f264f764df0c44fdbd75e4956098ff5f
Publikováno v:
Data in Brief, Vol 27, Iss , Pp - (2019)
Nematostella vectensis is an estuarine sea anemone that has emerged as a model species to characterize molecular responses to physiological stressors due to its exposure to diverse, extreme abiotic conditions. In marine cnidarians, Hsp70 proteins can
Externí odkaz:
https://doaj.org/article/c65c65a711384ec9aa67353773daf1fb
Autor:
Franziska Leipoldt, Javier Santos-Aberturas, Dennis P. Stegmann, Felix Wolf, Andreas Kulik, Rodney Lacret, Désirée Popadić, Daniela Keinhörster, Norbert Kirchner, Paulina Bekiesch, Harald Gross, Andrew W. Truman, Leonard Kaysser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Metalloproteinase inhibitors are leads for drug development, but their biosynthetic pathways are often unknown. Here the authors show that the acyl branched warhead of actinonin and matlystatins derives from an ethylmalonyl-CoA-like pathway and the s
Externí odkaz:
https://doaj.org/article/33d55bdb2e15447e910a355a7a9c3566
Autor:
Natela Dushukyan, Diana M. Dunn, Rebecca A. Sager, Mark R. Woodford, David R. Loiselle, Michael Daneshvar, Alexander J. Baker-Williams, John D. Chisholm, Andrew W. Truman, Cara K. Vaughan, Timothy A. Haystead, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 21, Iss 7, Pp 1883-1895 (2017)
Summary: The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-transl
Externí odkaz:
https://doaj.org/article/1fd7653e1f7244c682e707f46ef9dd06