Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Andrew W. Truman"'
Autor:
Alaster D. Moffat, Lars Höing, Javier Santos-Aberturas, Tim Markwalder, Jacob G. Malone, Robin Teufel, Andrew W. Truman
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT The genus Pseudomonas is a prolific source of specialized metabolites with significant biological activities, including siderophores, antibiotics, and plant hormones. These molecules play pivotal roles in environmental interactions, influenc
Externí odkaz:
https://doaj.org/article/673fc1d37a644b1dab6318c14f2291d4
Autor:
Yuka Okusha, Martin E. Guerrero-Gimenez, Benjamin J. Lang, Thiago J. Borges, Mary A. Stevenson, Andrew W. Truman, Stuart K. Calderwood
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The dynamic network of chaperone interactions known as the chaperome contributes significantly to the proteotoxic cell response and the malignant phenotype. To bypass the inherent redundancy in the network, we have used a microRNA (mir) appr
Externí odkaz:
https://doaj.org/article/08c5c3ecf3294ec38e46e5dccd87122b
Autor:
Justin A. Davis, Andres V. Reyes, Nitika, Arpita Saha, Donald J. Wolfgeher, Shou-Ling Xu, Andrew W. Truman, Bibo Li, Kausik Chakrabarti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which p
Externí odkaz:
https://doaj.org/article/8b242566a6fc46348656b995a5720a6e
Autor:
Nitika, Bo Zheng, Linhao Ruan, Jake T Kline, Siddhi Omkar, Jacek Sikora, Mara Texeira Torres, Yuhao Wang, Jade E Takakuwa, Romain Huguet, Cinzia Klemm, Verónica A Segarra, Matthew J Winters, Peter M Pryciak, Peter H Thorpe, Kazuo Tatebayashi, Rong Li, Luca Fornelli, Andrew W Truman
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001839 (2022)
Hsp70 interactions are critical for cellular viability and the response to stress. Previous attempts to characterize Hsp70 interactions have been limited by their transient nature and the inability of current technologies to distinguish direct versus
Externí odkaz:
https://doaj.org/article/59fc76cc577d413db19b096830ece4f5
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010079 (2022)
The Hsp70 family of molecular chaperones is well-conserved and expressed in all organisms. In budding yeast, cells express four highly similar cytosolic Hsp70s Ssa1, 2, 3 and 4 which arose from gene duplication. Ssa1 and 2 are constitutively expresse
Externí odkaz:
https://doaj.org/article/2944bc638b1e47ea954c96f4ad42f915
Autor:
Alicia H. Russell, Andrew W. Truman
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1838-1851 (2020)
Genome mining is a computational method for the automatic detection and annotation of biosynthetic gene clusters (BGCs) from genomic data. This approach has been increasingly utilised in natural product (NP) discovery due to the large amount of seque
Externí odkaz:
https://doaj.org/article/5b4834da3f96450c84c8b96ef4a903fd
Autor:
Alba Pacheco-Moreno, Francesca L Stefanato, Jonathan J Ford, Christine Trippel, Simon Uszkoreit, Laura Ferrafiat, Lucia Grenga, Ruth Dickens, Nathan Kelly, Alexander DH Kingdon, Liana Ambrosetti, Sergey A Nepogodiev, Kim C Findlay, Jitender Cheema, Martin Trick, Govind Chandra, Graham Tomalin, Jacob G Malone, Andrew W Truman
Publikováno v:
eLife, Vol 10 (2021)
Agricultural soil harbors a diverse microbiome that can form beneficial relationships with plants, including the inhibition of plant pathogens. Pseudomonas spp. are one of the most abundant bacterial genera in the soil and rhizosphere and play import
Externí odkaz:
https://doaj.org/article/bbff8fd243fa448d851f98120748db8b
Autor:
Natalia Ricco, Amy Flor, Don Wolfgeher, Elena V. Efimova, Aishwarya Ramamurthy, Oliver K. Appelbe, Jacqueline Brinkman, Andrew W. Truman, Michael T. Spiotto, Stephen J. Kron
Publikováno v:
Molecular Oncology, Vol 13, Iss 9, Pp 1927-1943 (2019)
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors (statins) may overcome resistance. Proteomic
Externí odkaz:
https://doaj.org/article/c9b43aab1c114bd4b7546f87f2756ce4
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 864 (2022)
Molecular chaperones such as Hsp70 and Hsp90 help fold and activate proteins in important signal transduction pathways that include DNA damage response (DDR). Previous studies have suggested that the levels of the mammalian APE2 exonuclease, a protei
Externí odkaz:
https://doaj.org/article/e5fc1fdeed1941f3ac2fb2a6a48dd9d8
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Bottromycin is a ribosomally synthesized and post-translationally modified peptide (RiPP) produced by several streptomycetes, including the plant pathogen Streptomyces scabies. There is significant interest in this molecule as it possesses strong ant
Externí odkaz:
https://doaj.org/article/f264f764df0c44fdbd75e4956098ff5f