Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Andrew W. Sylwester"'
Autor:
Xiao L. Chang, Helen L. Wu, Gabriela M. Webb, Meenakshi Tiwary, Colette Hughes, Jason S. Reed, Joseph Hwang, Courtney Waytashek, Carla Boyle, Cleiton Pessoa, Andrew W. Sylwester, David Morrow, Karina Belica, Miranda Fischer, Scott Kelly, Nader Pourhassan, Rachele M. Bochart, Jeremy Smedley, Christopher P. Recknor, Scott G. Hansen, Jonah B. Sacha
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major HIV entry co-receptor, where its surface density correlates with HIV plas
Externí odkaz:
https://doaj.org/article/90d1587b8e514b8db82121653a4bb63e
Autor:
Joseph Hwang, Andrew W. Sylwester, Meenakshi Tiwary, Rachele M. Bochart, Gabriela M. Webb, Courtney Waytashek, Colette M. Hughes, Scott Kelly, Xiao L. Chang, Jason S. Reed, Carla Boyle, Scott G. Hansen, Miranda Fischer, Jeremy Smedley, Helen L. Wu, Nader Pourhassan, Cleiton Pessoa, Jonah B. Sacha, Christopher P. Recknor, David Morrow, Karina Belica
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
CCR5 plays a central role in infectious disease, host defense, and cancer progression, thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major HIV entry co-receptor, where its surface density correlates with HIV plas
Autor:
Andrew W. Sylwester, James Hair, Scott A. Hammond, Qun Du, Nicholas Buss, Lolke de Haan, Michael Oberst, Kathy Mulgrew, Louis J. Picker, Michael K. Axthelm, Melissa Damschroder, Hui Feng, Andrew D. Weinberg, Haesun Park, Shino Hanabuchi, Steven Eck, Stacy R. Kentner, Chad Morris, Kelly McGlinchey, Nicholas P. Morris, Andrew J. Pierce, Catherine Auge
Publikováno v:
Molecular Cancer Therapeutics. 17:1024-1038
Ligation of OX40 (CD134, TNFRSF4) on activated T cells by its natural ligand (OX40L, CD252, TNFSF4) enhances cellular survival, proliferation, and effector functions such as cytokine release and cellular cytotoxicity. We engineered a recombinant huma
Autor:
Emily Ainslie, Colette M. Hughes, Alan Aderem, Louis J. Picker, Scott G. Hansen, Thomas G. Evans, Michele Stone, Shannon L. Planer, Abigail B. Ventura, Daniel Malouli, Smitha Shankar, Guangwu Xu, Daniel E. Zak, Aurelio Bonavia, Roxanne M. Gilbride, Parker Rundstrom, Alfred W. Legasse, Lynn M. Amon, Christina Armstrong, Lauren Herlache, Kurt T. Randall, Robert C. Zweig, Martin Messerle, Dominick Laddy, John M. Turner, Klaus Früh, Haesun Park, Michael A. Jarvis, Emily E. Marshall, Andrea N. Selseth, Miranda Fischer, Joseph Valvo, Jackie Braun, Andrew W. Sylwester, Galit Alter, Michael K. Axthelm, Julia C. Ford, Lenette L. Lu, Paul T. Edlefsen, Matthew S. Lewis
Publikováno v:
Nature Medicine. 24:130-143
Despite widespread use of the bacille Calmette-Guerin (BCG) vaccine, tuberculosis (TB) remains a leading cause of global mortality from a single infectious agent (Mycobacterium tuberculosis or Mtb). Here, over two independent Mtb challenge studies, w
Autor:
Andrew W. Sylwester, Jay H. Bream, Louis J. Picker, Sean X. Leng, Tricia L. Nilles, Hanhvy T. Bui, Susan Langan, Joseph B. Margolick, Huifen Li
Publikováno v:
The Journal of Infectious Diseases. 210:400-404
Increasing evidence suggests that chronic cytomegalovirus (CMV) infection significantly impacts T-cell immunity in human immunodeficiency virus (HIV) infection and aging [1–3]. Most of this evidence consists of analysis of T cells specific to epito
Autor:
Louis J. Picker, Paul Klenerman, Andrew W. Sylwester, Florian Kern, Stefano Caserta, Kate Nambiar
Background: In studies exploring the effects of HCMV infection on immune system aging (‘immunosenescence’), after organ transplantation or in other settings, HCMV-specific T-cell responses are often assessed with respect to purportedly ‘immunod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad33d668794330edfa917063cce47a9
http://sro.sussex.ac.uk/id/eprint/60019/5/1-s2.0-S0047637416300239-main.pdf
http://sro.sussex.ac.uk/id/eprint/60019/5/1-s2.0-S0047637416300239-main.pdf
Autor:
Andrew W. Sylwester, Mukta Rohankhedkar, Chike O. Abana, Byung Park, Afam A. Okoye, Richard Lum, Christopher Pexton, Matthew D. Reyes, Alfred W. Legasse, Michael Piatak, Louis J. Picker, Shannon L. Planer, Audrie Pattenn, Michael K. Axthelm, Jeffrey D. Lifson
Publikováno v:
The Journal of Experimental Medicine
Memory CD4+ T cell homeostasis and AIDS progression are independent of naive CD4+ T cells in SIV infection of nonhuman primates.
The development of AIDS in chronic HIV/simian immunodeficiency virus (SIV) infection has been closely linked to prog
The development of AIDS in chronic HIV/simian immunodeficiency virus (SIV) infection has been closely linked to prog
Autor:
Alfred W. Legasse, Noreen Currier, Caroline Koudelka, Andrew W. Sylwester, Michael K. Axthelm, Shoko I. Hagen, Luka Cicin-Sain, Louis J. Picker, Janko Nikolich-Žugich, Don Siess, Miranda Fischer
Publikováno v:
The Journal of Immunology. 187:1722-1732
Although CMV infection is largely benign in immunocompetent people, the specific T cell responses associated with control of this persistent virus are enormous and must be maintained for life. These responses may increase with advanced age and have b
Autor:
Mukta Rohankhedkar, Lia Coyne-Johnson, Louis J. Picker, Joshua M. Walker, Richard Lum, Haesun Park, Andrew W. Sylwester, Alfred W. Legasse, Joern E. Schmitz, Michael K. Axthelm, Donald L. Sodora, Michael Piatak, Shannon L. Planer, Francois Villinger, Jeffrey D. Lifson, Afam A. Okoye
Publikováno v:
The Journal of Experimental Medicine
Depletion of CD8(+) lymphocytes during acute simian immunodeficiency virus (SIV) infection of rhesus macaques (RMs) results in irreversible prolongation of peak-level viral replication and rapid disease progression, consistent with a major role for C
Autor:
Jason M. Brenchley, Jeffrey D. Lifson, Donald L. Sodora, Alfred W. Legasse, Martin Meier-Schellersheim, Afam A. Okoye, John B. Edgar, Michael Piatak, Shoko I. Hagen, Vernon C. Maino, Michael K. Axthelm, Shannon L. Planer, Joshua M. Walker, Richard Lum, Mukta Rohankhedkar, Louis J. Picker, Andrew W. Sylwester, Zvi Grossman, Daniel C. Douek
Publikováno v:
The Journal of Experimental Medicine
Primary simian immunodeficiency virus (SIV) infections of rhesus macaques result in the dramatic depletion of CD4(+) CCR5(+) effector-memory T (T(EM)) cells from extra-lymphoid effector sites, but in most infections, an increased rate of CD4(+) memor