Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Andrew W. Simonson"'
Publikováno v:
Molecules, Vol 25, Iss 12, p 2751 (2020)
Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as
Externí odkaz:
https://doaj.org/article/d7a221707c4c42ec96d6ddbc07b5dd6e
Autor:
Atip Lawanprasert, Andrew W. Simonson, Sarah E. Sumner, McKayla J. Nicol, Sopida Pimcharoen, Girish S. Kirimanjeswara, Scott H. Medina
Publikováno v:
Biomacromolecules
Coronavirus disease 2019 (Covid-19) has caused over 5.5 million deaths worldwide, and viral mutants continue to ravage communities with limited access to injectable vaccines or high rates of vaccine hesitancy. Inhalable vaccines have the potential to
Autor:
Andrew W. Simonson, Kenneth C. Keiler, Scott H. Medina, Atip Lawanprasert, Tyler D. P. Goralski
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 17:391-400
We report the design, synthesis and efficacy of a new class of gel-like nano-carrier, or 'nanogel', prepared via templated electrostatic assembly of anionic hyaluronic acid (HA) polysaccharides with the cationic peptide amphiphile poly-L-lysine (PLL)
The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
Autor:
Andrew W Simonson, Allison N Bucsan, Joseph J Zeppa, Caylin G Winchell, Amy J Myers, Matthew Sutton, Cassaundra L Ameel, Patricia A Darrah, Mario Roederer, Robert A Seder, JoAnne L Flynn
Publikováno v:
The Journal of Immunology. 208:181.11-181.11
Background We previously demonstrated in non-human primates (NHP) that intravenous (IV) administration of BCG induces substantial T cell responses and often sterilizing immunity against Mycobacterium tuberculosis (Mtb) infection. Here, we investigate
Autor:
Christy George, John N. Alumasa, Adam Bolotsky, Michael D. Howe, Anthony D. Baughn, Dennis C. Chan, Andrew W. Simonson, Scott H. Medina, Elizabeth A. Proctor, Tapas K. Mal, Kenneth C. Keiler, Agustey S. Mongia, Atip Lawanprasert, Matthew R. Aronson, Aida Ebrahimi
Publikováno v:
Nature biomedical engineering
Precision antimicrobials aim to kill pathogens without damaging commensal bacteria in the host, and thereby cure disease without antibiotic-associated dysbiosis. Here we report the de novo design of a synthetic host defence peptide that targets a spe
Autor:
Katherine M. Aird, Matthew R. Aronson, Jacob A. Halle, Rose A. Gogal, Andrew W. Simonson, Scott H. Medina, Adam B. Glick, Erika S. Dahl
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: Bacteria and cancer cells share a common trait—both possess an electronegative surface that distinguishes them from healthy mammalian counterparts. This opens opportunities to repurpose antimicrobial peptides (AMPs), which are cationi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1d0253160446bb128f8dd700fa165d
https://europepmc.org/articles/PMC7596148/
https://europepmc.org/articles/PMC7596148/
Autor:
Elizabeth A. Proctor, Agustey S. Mongia, Kenneth C. Keiler, Andrew W. Simonson, Dennis C. Chan, Aida Ebrahimi, Matthew R. Aronson, John N. Alumasa, Adam Bolotsky, Scott H. Medina
Precision antimicrobials that can kill pathogens without damaging host commensals hold potential to cure disease without antibiotic-associated dysbiosis. Here we report the de novo design of host defense peptides that have been rationally engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9764a2c27e9275a2abfacb11be4153
https://doi.org/10.26434/chemrxiv.12267992
https://doi.org/10.26434/chemrxiv.12267992
Publikováno v:
Molecules, Vol 25, Iss 2751, p 2751 (2020)
Molecules
Molecules
Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of non-conventional therapies that act on new targets or employ novel mechanisms. Among these, supramolecular antimicrobial peptide assemblies have emerged as
Publikováno v:
Acta biomaterialia. 80
Anticancer peptides (ACPs) are cationic amphiphiles that preferentially kill cancer cells through folding-dependent membrane disruption. Although ACPs represent attractive therapeutic candidates, particularly against drug-resistant cancers, their suc
Autor:
Simonson, Andrew W., Mongia, Agustey S., Aronson, Matthew R., Alumasa, John N., Chan, Dennis C., Lawanprasert, Atip, Howe, Michael D., Bolotsky, Adam, Mal, Tapas K., George, Christy, Ebrahimi, Aida, Baughn, Anthony D., Proctor, Elizabeth A., Keiler, Kenneth C., Medina, Scott H.
Publikováno v:
Nature Biomedical Engineering; May2021, Vol. 5 Issue 5, p467-480, 14p