Výsledky vyhledávání - "Andrew W. McFadden"

Akademický článek

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing

Autor: Tamara Vital, Aminah Wali, Kyle V. Butler, Yan Xiong, Joseph P. Foster, Shelsa S. Marcel, Andrew W. McFadden, Valerie U. Nguyen, Benton M. Bailey, Kelsey N. Lamb, Lindsey I. James, Stephen V. Frye, Amber L. Mosely, Jian Jin, Samantha G. Pattenden, Ian J. Davis

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment o

Externí odkaz: https://doaj.org/article/7ebda3c984ec4911991fbe839ad7aab9

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Data Supplement from PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition

Autor: Ian J. Davis, Kathleen Kaiser-Rogers, Scott V. Smith, Jeremy M. Simon, Travis Sapp, Andres Rojas, Sam Wu, Billie M. Moats-Staats, Andrew W. McFadden, Nicholas C. Gomez, Mukund Patel

Sup. Figure 1. MHH-ES-1 and RD-ES are triploid for chromosome 10. Sup. Figure 2. PTEN copy number variation in primary Ewing sarcoma. Sup. Figure 3. PTEN immunofluoresence is concordant with immunoblotting. Sup Figure 4. Immunofluoresence and immunoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d59997c08d132b4db71670f217239c9
https://doi.org/10.1158/1541-7786.22511833.v1

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Data from PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition

Autor: Ian J. Davis, Kathleen Kaiser-Rogers, Scott V. Smith, Jeremy M. Simon, Travis Sapp, Andres Rojas, Sam Wu, Billie M. Moats-Staats, Andrew W. McFadden, Nicholas C. Gomez, Mukund Patel

Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of Ewing sarcoma, a highly malignant bone and soft-tissue tumor that primarily affects children and young adults. Despite promising results from preclinical studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebd6fe85ba8376204f0d2341edcde613
https://doi.org/10.1158/1541-7786.c.6540052.v1

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Data from Identification of the Receptor Tyrosine Kinase c-Met and Its Ligand, Hepatocyte Growth Factor, as Therapeutic Targets in Clear Cell Sarcoma

Autor: David E. Fisher, Andrew J. Wagner, Teresa L. Burgess, Angela Coxon, Yixiang Zhang, Andrew W. McFadden, Ian J. Davis

Clear cell sarcoma (CCS), a childhood tumor of the tendons and aponeuroses, is uniformly fatal once it has metastasized because of its profound therapeutic resistance. CCS is characterized by production of a chimeric transcription factor, EWS-ATF1, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a80bbfbc3f9b33f0289e63eaeb188f
https://doi.org/10.1158/0008-5472.c.6500070.v1

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PBRM1 bromodomains variably influence nucleosome interactions and cellular function

Autor: Lindsey E. Suttle, Emily S. Hollis, Mariesa J. Slaughter, Andrew W. McFadden, Erin K. Shanle, Brian D. Strahl, Ian J. Davis

Publikováno v: Journal of Biological Chemistry. 293:13592-13603

Chromatin remodelers use bromodomains (BDs) to recognize histones. Polybromo 1 (PBRM1 or BAF180) is hypothesized to function as the nucleosome-recognition subunit of the PBAF chromatin-remodeling complex and is frequently mutated in clear cell renal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98b69b54669083fb96e8af8ee87508b
https://doi.org/10.1074/jbc.ra118.003381

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High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility

Autor: Aminah Wali, Cameron Champion Wood, Joshua Wooten, Jacob Troutman, Andrew W. McFadden, Samantha G. Pattenden, Stephen V. Frye, William P. Janzen, Jeremy M. Simon, Chatura N. Jayakody, Ian J. Davis

Mutations in chromatin-modifying proteins and transcription factors are commonly associated with a wide variety of cancers. Through gain- or loss-of-function, these mutations may result in characteristic alterations of accessible chromatin, indicativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fd36265da0f92d4a2e171ecd2b6949

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Identification of the Receptor Tyrosine Kinase c-Met and Its Ligand, Hepatocyte Growth Factor, as Therapeutic Targets in Clear Cell Sarcoma

Autor: Yixiang Zhang, Andrew W. McFadden, Andrew J. Wagner, Angela Coxon, David E. Fisher, Teresa L. Burgess, Ian J. Davis

Publikováno v: Cancer Research. 70:639-645

Clear cell sarcoma (CCS), a tumor of the tendons and aponeuroses of children and young adults, is uniformly fatal once metastatic, exhibiting profound resistance to radio- and chemotherapy. Implicated in human cancer, the receptor tyrosine kinase c-M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e84352326fabf3aab133e7dbe0b736c
https://doi.org/10.1158/0008-5472.can-09-1121

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CIB1 Regulates Endothelial Cells and Ischemia-Induced Pathological and Adaptive Angiogenesis

Autor: Mohamed A. Zayed, Michael D. Schaller, Dan Chalothorn, Tina M. Leisner, James E. Faber, Weiping Yuan, M. Elizabeth Hartnett, Leslie V. Parise, Andrew W. McFadden

Publikováno v: Circulation Research. 101:1185-1193

Pathological angiogenesis contributes to various ocular, malignant, and inflammatory disorders, emphasizing the need to understand this process on a molecular level. CIB1 (calcium- and integrin-binding protein), a 22-kDa EF-hand–containing protein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc994976facc73270ecaed460fb53729
https://doi.org/10.1161/circresaha.107.157586

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