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of 3
pro vyhledávání: '"Andrew W. Leamy"'
Autor:
Michael J. Carr, Srinivas Ghatta, Praveen K. Shukla, Michael Allen McAlexander, Andrew W. Leamy
Publikováno v:
Neuroscience Letters. 503:157-162
The ion channel TRPA1 is activated by a wide variety of noxious stimuli, such as pollutants, products of oxidative tissue damage, and pungent natural products. Many TRPA1 activators are reactive electrophiles that form Michael adducts with cysteine a
Publikováno v:
The FASEB Journal. 24
Many TRPA1 ion channel activators are reactive electrophiles that form Michael adducts with cysteine and lysine residues in TRPA1’s intracellular N-terminus. Curcumin (CUR), the active principle of...
Autor:
George A. Boswell, Andrew W. Leamy, Pieter B.M.W.M. Timmermans, Martin J.M.C. Thoolen, Denver P. Fernando, Dolores E. Rasbach, William M. Mackin, Robert M. Knabb
Publikováno v:
Journal of Cardiovascular Pharmacology. 17:390-396
Activated neutrophils and possibly xanthine oxidase-derived free radicals are believed to be mediators of ischemia and reperfusion-induced myocardial damage. We studied the cardioprotective effect of the neutrophil stabilizer and xanthine oxidase inh