Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Andrew W Pountain"'
Autor:
Edubiel A Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W Pountain, Stefan K Weidt, Anne M Donachie, Ryan Ritchie, Emily A Dickie, Richard J S Burchmore, Paul W Denny, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010779 (2022)
Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin.
Externí odkaz:
https://doaj.org/article/d236c07b263b428594e99eab4248e1b2
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Candida species are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including Candida albicans, the most prevalent cause of inf
Externí odkaz:
https://doaj.org/article/c406d6b66d4a4a9b8be664b1f95c9668
Autor:
Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1008932 (2020)
Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promis
Externí odkaz:
https://doaj.org/article/a5d1aac4a0fd47b29679ea476bd015f8
Autor:
Andrew W. Pountain, Michael P. Barrett
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the pote
Externí odkaz:
https://doaj.org/article/af30225dfcbf49a8a62a820f2d74fa8d
Autor:
Andrew W Pountain, Stefan K Weidt, Clément Regnault, Paul A Bates, Anne M Donachie, Nicholas J Dickens, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007052 (2019)
Amphotericin B is an increasingly important tool in efforts to reduce the global disease burden posed by Leishmania parasites. With few other chemotherapeutic options available for the treatment of leishmaniasis, the potential for emergent resistance
Externí odkaz:
https://doaj.org/article/02c7db962fdf4558835e9797401ea3bc
Autor:
Andrew W. Pountain, Peien Jiang, Tianyou Yao, Ehsan Homaee, Yichao Guan, Magdalena Podkowik, Bo Shopsin, Victor J. Torres, Ido Golding, Itai Yanai
Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome1. These modes interact with a changing cellular environment to yield highly dynamic expression patterns2. In bacteria, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb775dbc0337310014fbad6e414b5179
https://doi.org/10.21203/rs.3.rs-2724389/v1
https://doi.org/10.21203/rs.3.rs-2724389/v1
Autor:
Julie Kovářová, Andrew W Pountain, David Wildridge, Stefan Weidt, Frédéric Bringaud, Richard J S Burchmore, Fiona Achcar, Michael P Barrett
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006953 (2018)
Transketolase (TKT) is part of the non-oxidative branch of the pentose phosphate pathway (PPP). Here we describe the impact of removing this enzyme from the pathogenic protozoan Leishmania mexicana. Whereas the deletion had no obvious effect on cultu
Externí odkaz:
https://doaj.org/article/41defa5f74b146699e269d27a96a2d9a
Autor:
Kevin M Rattigan, Andrew W Pountain, Clement Regnault, Fiona Achcar, Isabel M Vincent, Carl S Goodyear, Michael P Barrett
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194126 (2018)
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory
Externí odkaz:
https://doaj.org/article/b4f18042a6cb4ffd80648fe1854f421e
Autor:
Alicia Ponte-Sucre, Francisco Gamarro, Jean-Claude Dujardin, Michael P Barrett, Rogelio López-Vélez, Raquel García-Hernández, Andrew W Pountain, Roy Mwenechanya, Barbara Papadopoulou
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006052 (2017)
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing problem. Drug resistance is a fundamental determinant of treatment failure, although other factor
Externí odkaz:
https://doaj.org/article/5f0c7b9c1030434c8c5c6249ae3f5cbe
Autor:
Roy Mwenechanya, Julie Kovářová, Nicholas J Dickens, Manikhandan Mudaliar, Pawel Herzyk, Isabel M Vincent, Stefan K Weidt, Karl E Burgess, Richard J S Burchmore, Andrew W Pountain, Terry K Smith, Darren J Creek, Dong-Hyun Kim, Galina I Lepesheva, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005649 (2017)
Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understandi
Externí odkaz:
https://doaj.org/article/6745f44e729541bfb242217950694ec9