Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Andrew W Norris"'
Autor:
Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Richard K Shields, Andrew W Norris, Gary Patti, Leonid V Zingman, Eric B Taylor
Publikováno v:
eLife, Vol 8 (2019)
Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic cycling between lactate and glucose. Here, skeletal muscle-specific Mitochondrial Pyruvate Car
Externí odkaz:
https://doaj.org/article/13cd1adfdce945bdbb60969f1404d117
Autor:
Pavana G. Rotti, Yaling Yi, Grace Gasser, Feng Yuan, Xingshen Sun, Idil Apak-Evans, Peipei Wu, Guangming Liu, Soon Choi, Rosie Reeves, Attilina E. Scioneaux, Yulong Zhang, Michael Winter, Bo Liang, Nathan Cunicelli, Aliye Uc, Andrew W. Norris, Lori Sussel, Kristen L. Wells, John F. Engelhardt
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111393- (2024)
Summary: Inflammation, acinar atrophy, and ductal hyperplasia drive pancreatic remodeling in newborn cystic fibrosis (CF) ferrets lacking a functional cystic fibrosis conductance regulator (CFTR) channel. These changes are associated with a transient
Externí odkaz:
https://doaj.org/article/adf31ce97f1349c6913af02b6606f692
Autor:
Hongshu Sui, Yaling Yi, Jianrong Yao, Bo Liang, Xingshen Sun, Shanming Hu, Aliye Uc, Deborah J Nelson, Katie Larson Ode, Louis H Philipson, John F Engelhardt, Andrew W Norris
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90519 (2014)
Ferrets are an important emerging model of cystic fibrosis related diabetes. However, there is little documented experience in the use of advanced techniques to quantify aspects of diabetes pathophysiology in the ferret. Glycemic clamps are the gold
Externí odkaz:
https://doaj.org/article/bb25f996055e47678ff1fd0d26ef77c4
Autor:
Jianrong Yao, Chunlin Wang, Susan A Walsh, Shanming Hu, Alexander B Sawatzke, Diana Dang, Jeffrey L Segar, Laura L B Ponto, John J Sunderland, Andrew W Norris
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12027 (2010)
Complex but common maternal diseases such as diabetes and obesity contribute to adverse fetal outcomes. Understanding of the mechanisms involved is hampered by difficulty in isolating individual elements of complex maternal states in vivo. We approac
Externí odkaz:
https://doaj.org/article/2f204af4d4534c4ba56438db2c0d53b2
Autor:
Qiuxia Li, Quanjiang Zhang, Young-Rae Kim, Ravinder Reddy Gaddam, Julia S. Jacobs, Markus M. Bachschmid, Tsneem Younis, Zhiyong Zhu, Leonid Zingman, Barry London, Adam J. Rauckhorst, Eric B. Taylor, Andrew W. Norris, Ajit Vikram, Kaikobad Irani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Downregulation of endothelial Sirtuin1 (Sirt1) in insulin resistant states contributes to vascular dysfunction. Furthermore, Sirt1 deficiency in skeletal myocytes promotes insulin resistance. Here, we show that deletion of endothelial Sirt1,
Externí odkaz:
https://doaj.org/article/72b47199e1ba4328a43cb9d21627ccbf
Autor:
Susheel K. Gunasekar, Litao Xie, Ashutosh Kumar, Juan Hong, Pratik R. Chheda, Chen Kang, David M. Kern, Chau My-Ta, Joshua Maurer, John Heebink, Eva E. Gerber, Wojciech J. Grzesik, Macaulay Elliot-Hudson, Yanhui Zhang, Phillip Key, Chaitanya A. Kulkarni, Joseph W. Beals, Gordon I. Smith, Isaac Samuel, Jessica K. Smith, Peter Nau, Yumi Imai, Ryan D. Sheldon, Eric B. Taylor, Daniel J. Lerner, Andrew W. Norris, Samuel Klein, Stephen G. Brohawn, Robert Kerns, Rajan Sah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated li
Externí odkaz:
https://doaj.org/article/f4d1fee19c624c0a9f1b40ef56f78e04
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Turner syndrome (TS) is a common chromosomal disorder resulting from complete or partial absence of the second sex chromosome. Hyperglycemia, ranging from impaired glucose tolerance (IGT) to diabetes mellitus (DM), is common in TS. DM in individuals
Externí odkaz:
https://doaj.org/article/466c3742da354410be72a32c82bac0cb
Autor:
Christine L. Chan, Andrea Granados, Amir Moheet, Sachinkumar Singh, Timothy Vigers, Ana Maria Arbeláez, Yaling Yi, Shanming Hu, Andrew W. Norris, Katie Larson Ode
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 30, Iss , Pp 100311- (2022)
Background: Diabetes is prevalent among people with CF (PwCF) and associated with worse clinical outcomes. CFTR modulators are highly effective in improving the disease course of CF. However, the effects of elexacaftor/tezacaftor/ivacaftor (ETI) on g
Externí odkaz:
https://doaj.org/article/316d9cb57ebf475b8bd56a5deb9465d7
Autor:
Sriya Subramani, Andrew M. Bellizzi, Nicholas Borcherding, Simon C. Kao, Joseph Dillon, James Howe, Andrew W. Norris, Michael J. Tansey, Catherina T. Pinnaro
Publikováno v:
Clinical Case Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Abstract Type 1 diabetes and insulinoma can co‐occur in pediatric patients and may present with episodes of hypo‐ and hyperglycemia, significant glycemic variability, and weight gain. Surgical resection leads to development of fulminant diabetes.
Externí odkaz:
https://doaj.org/article/6d9164ad6a444d828dc4f28a968a7a64
Autor:
Melissa S. Putman, Andrew W. Norris, Rebecca L. Hull, Michael R. Rickels, Lori Sussel, Scott M. Blackman, Christine L. Chan, Katie Larson Ode, Tanicia Daley, Arlene A. Stecenko, Antoinette Moran, Meagan J. Helmick, Sharon Cray, Jessica A. Alvarez, Virginia A. Stallings, Katherine L. Tuggle, John P. Clancy, Thomas L. Eggerman, John F. Engelhardt, Andrea Kelly
Publikováno v:
Diabetes. 72:677-689
Cystic fibrosis (CF) is a recessive disorder arising from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is expressed in numerous tissues, with high expression in the airways, small and lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb55f5e1de29e45a35794f2f19379ee
https://doi.org/10.2337/db22-0949
https://doi.org/10.2337/db22-0949