Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Andrew W, Trafford"'
Autor:
Edward A. Hayter, Sophie M. T. Wehrens, Hans P. A. Van Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J. Barron, Luigi A. Venetucci, John S. O’ Neill, Timothy M. Brown, Debra J. Skene, Andrew W. Trafford, David A. Bechtold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cardiac function fluctuates greatly across the day and night, but this is not simply a consequence of our changing behaviour. The authors highlight the role of the body’s circadian clock in regulating the heart electrical activity, including a time
Externí odkaz:
https://doaj.org/article/530c60e952014c1cb2858a92a8c76775
Autor:
Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D’Hont, Katharine M. Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya R. Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie A. Jerome-Majewska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J. Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew W. Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D. Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, K. C. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano, Gaetan Burgio
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up to 16% effi
Externí odkaz:
https://doaj.org/article/d080d0cd1924426bb1475dd31116c836
Autor:
Nathan C. Denham, Charles M. Pearman, George W. P. Madders, Charlotte E. R. Smith, Andrew W. Trafford, Katharine M. Dibb
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundLarge animal models play an important role in our understanding of the pathophysiology of atrial fibrillation (AF). Our aim was to determine whether prospectively collected baseline variables could predict the development of sustained AF in
Externí odkaz:
https://doaj.org/article/9b71963249ce40c8b1e5a1e1a29a2c65
Autor:
Emma J. Radcliffe, Charles M. Pearman, Amy Watkins, Michael Lawless, Graeme J. Kirkwood, Sophie N. Saxton, David A. Eisner, Andrew W. Trafford
Publikováno v:
Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Autonomic dysregulation plays a key role in the development and progression of heart failure (HF). Vagal nerve stimulation (VNS) may be a promising therapeutic approach. However, the outcomes from clinical trials evaluating VNS in HF have be
Externí odkaz:
https://doaj.org/article/94a805943b3141dc99028ded915d88c6
Autor:
Claire Wilson, Nicholas Stafford, Min Zi, Alexandru Chelu, Barbara C. Niort, Yatong Li, Florence Baudoin, Sukhpal Prehar, Andrew W. Trafford, Elizabeth J. Cartwright
Publikováno v:
Journal of Molecular and Cellular Cardiology. 172:41-51
Plasma membrane calcium ATPase 1 (PMCA1, Atp2b1) is emerging as a key contributor to cardiac physiology, involved in calcium handling and myocardial signalling. In addition, genome wide association studies have associated PMCA1 in several areas of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca367321e1480a1e7f420eea409c924
https://doi.org/10.1016/j.yjmcc.2022.07.011
https://doi.org/10.1016/j.yjmcc.2022.07.011
Autor:
Edward A. Hayter, Sophie M. T. Wehrens, Hans P. A. Van Dongen, Alessandra Stangherlin, Shobhan Gaddameedhi, Elena Crooks, Nichola J. Barron, Luigi A. Venetucci, John S. O’Neill, Timothy M. Brown, Debra J. Skene, Andrew W. Trafford, David A. Bechtold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/af3e22bd3d8c486d8552720ff8489fea
Autor:
David C. Hutchings, George W. P. Madders, Barbara C. Niort, Elizabeth F. Bode, Caitlin A. Waddell, Lori S. Woods, Katharine M. Dibb, David A. Eisner, Andrew W. Trafford
Publikováno v:
Hutchings, D, Madders, G, Niort, B, Bode, E, Waddell, C, Woods, L, Dibb, K, Eisner, D & Trafford, A 2022, ' Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart ', JOURNAL OF PHYSIOLOGY-LONDON . https://doi.org/10.1113/JP282168
Key pointsHeart failure is a pro-arrhythmic state and arrhythmias are a major cause of death. At the cellular level, Ca2+ waves resulting in delayed after-depolarisations are a key trigger of arrhythmias. Ca2+ waves arise when the sarcoplasmic reticu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9002a54cd6ba1eab318aba7f54cc61
https://doi.org/10.1113/jp282168
https://doi.org/10.1113/jp282168
Ischaemic heart disease remains a leading cause of premature mortality and morbidity. Understanding the associated pathophysiological mechanisms of cardiac dysfunction arising from ischaemic heart disease and the identification of sites of novel ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7394faf6ea814bcada863b1d8af3e4
https://doi.org/10.1101/2023.03.02.530817
https://doi.org/10.1101/2023.03.02.530817
Autor:
Charles M. Pearman, George W.P. Madders, Emma J. Radcliffe, Graeme J. Kirkwood, Michael Lawless, Amy Watkins, Charlotte E.R. Smith, Andrew W. Trafford, David A. Eisner, Katharine M. Dibb
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 23 (2018)
Background Atrial fibrillation (AF) is common in the elderly, but rare in the young; however, the changes that occur with age that promote AF are not fully understood. Action potential (AP) alternans may be involved in the initiation of AF. Using a t
Externí odkaz:
https://doaj.org/article/f7e1341037234cee820cd751d17b30eb
Autor:
Nathan C. Denham, Charles M. Pearman, Jessica L. Caldwell, George W. P. Madders, David A. Eisner, Andrew W. Trafford, Katharine M. Dibb
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship exists between the two—AF exacerbates heart failure causing a significant increase in heart failure symptoms, admissions to hospital and cardiovascular
Externí odkaz:
https://doaj.org/article/64909765f54e44ed91259196e8f432e2