Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Andrew W, Stoker"'
Publikováno v:
FEBS Open Bio, Vol 12, Iss 7, Pp 1388-1405 (2022)
Neuroblastoma (NB) is a heterogeneous cancer of the sympathetic nervous system, which accounts for 7–10% of paediatric malignancies worldwide. Due to the lack of targetable molecular aberrations in NB, most treatment options remain relatively nonsp
Externí odkaz:
https://doaj.org/article/e1ede00f8a904573ae2317a29585496c
Autor:
Elliott M. Thompson, Andrew W. Stoker
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 776 (2021)
Dual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular signalling pathways, which in turn influence a broad range of physiological processes. DUSP malfunction is increasingly observed in a broad range of human di
Externí odkaz:
https://doaj.org/article/41cc279e1627484eb7e7d54409410c9c
Autor:
Elsa Irving, Simon Eaton, Ari Lehtonen, Stephen L. Hart, Ruhina Maeshima, Andrew W. Stoker, Aristides D. Tagalakis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76348242b24a0011a0a8f1d024f2e8b7
http://link.springer.com/article/10.1038/s41598-020-73539-6
http://link.springer.com/article/10.1038/s41598-020-73539-6
Publikováno v:
Nucleic Acid Ther
Neuroblastoma (NB) is the most common solid tumor in childhood. Twenty percent of patients display MYCN amplification, which indicates a very poor prognosis. MYCN is a highly specific target for an NB tumor therapy as MYCN expression is absent or ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f126919877ba1421ebb25ff0d5c3a10e
https://doi.org/10.1089/nat.2019.0831
https://doi.org/10.1089/nat.2019.0831
Publikováno v:
International Journal of Biological Sciences, Vol 7, Iss 7, Pp 978-991 (2011)
Mouse protein tyrosine phosphatase PTPBR7 is a receptor-like, transmembrane protein that is localized on the surface of neuronal cells. Its protein phosphatase activity is reduced upon multimerization, and PTPBR7-deficient mice display motor coordina
Externí odkaz:
https://doaj.org/article/356eb848726a48c194d776ee30ba466e
Autor:
Elsa Irving, Andrew W. Stoker
Publikováno v:
Molecules, Vol 22, Iss 12, p 2269 (2017)
Phosphotyrosine signaling is regulated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here we discuss the potential of vanadium derivatives as PTP enzyme inhibitors and metallotherapeutics. We des
Externí odkaz:
https://doaj.org/article/0a5b8ba2623b4fdc8284ba755ef8e8e8
Autor:
Aristides D, Tagalakis, Vignesh, Jayarajan, Ruhina, Maeshima, Kin H, Ho, Farhatullah, Syed, Lin-Ping, Wu, Ahmad M, Aldossary, Mustafa M, Munye, Talisa, Mistry, Olumide Kayode, Ogunbiyi, Arturo, Sala, Joseph F, Standing, Seyed M, Moghimi, Andrew W, Stoker, Stephen L, Hart
Publikováno v:
Advanced functional materials. 31(37)
The authors aim to develop siRNA therapeutics for cancer that can be administered systemically to target tumors and retard their growth. The efficacy of systemic delivery of siRNA to tumors with nanoparticles based on lipids or polymers is often comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc27ac1195fc4326e0883ead95c8ca8d
https://pubmed.ncbi.nlm.nih.gov/35712226
https://pubmed.ncbi.nlm.nih.gov/35712226
Autor:
Andrew W. Stoker, Elliott M Thompson
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 776, p 776 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Dual specificity phosphatases (DUSPs) play a crucial role in the regulation of intracellular signalling pathways, which in turn influence a broad range of physiological processes. DUSP malfunction is increasingly observed in a broad range of human di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57db1f1c7d0b0a5f61f3ef5cf77bcb29
https://www.mdpi.com/1422-0067/22/2/776
https://www.mdpi.com/1422-0067/22/2/776
Autor:
Michael Orford, Stephen L. Hart, Elsa Irving, Claire Simons, Alessia Di Florio, Mayuran Mathiyalakan, Shreya Shah, Aristides D. Tagalakis, Maja Bilip, Andrew W. Stoker, Ruhina Maeshima, Simon Eaton
Publikováno v:
Journal of Drug Targeting
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells. However, although therapeutically effective, retinoids have only modest benefits and suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15558e37caa7d3d2630e0e1e269df268
Autor:
Lin-Ping Wu, Ahmad Aldossary, Stephen L. Hart, Olumide Ogunbiyi, Joseph F. Standing, Mustafa M. Munye, Talisa Mistry, Kin H. Ho, Aristides D. Tagalakis, Vignesh Jayarajan, Farhatullah Syed, Arturo Sala, Seyed Moein Moghimi, Ruhina Maeshima, Andrew W. Stoker
Publikováno v:
Advanced Functional Materials. 31:2104843
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9f7ddf4d45eed743a6bead39fbdeb1
https://doi.org/10.1002/adfm.202104843
https://doi.org/10.1002/adfm.202104843