Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Andrew W, Schaefer"'
Autor:
Ziqiao Ding, Antonio C. Roveda, Edward I. Solomon, Andrew W. Schaefer, Sylvia K. Choi, Wesley J. Transue, Anex Jose, Robert B. Gennis
Publikováno v:
Science
Breaking down oxygen Molecular oxygen (O 2 ) is the terminal oxidant for respiration in mitochondria and many bacteria. Within membrane-bound heme–copper oxidases, a controlled, four-electron reduction of O 2 to water is coupled to pumping of proto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ea2183f0460c6aabac09e3f2550d4f
https://doi.org/10.1126/science.abh3209
https://doi.org/10.1126/science.abh3209
Autor:
Kenneth D. Karlin, Edward I. Solomon, Patrick J. Rogler, Hyun Kim, Savita Sharma, Andrew W. Schaefer
Publikováno v:
Journal of the American Chemical Society. 142:3104-3116
Establishing redox and thermodynamic relationships between metal-ion-bound O2 and its reduced (and protonated) derivatives is critically important for a full understanding of (bio)chemical processes involving dioxygen processing. Here, a ferric heme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f564c0c79ff1ed9be5bc34e2d2df4a0b
https://doi.org/10.1021/jacs.9b12571
https://doi.org/10.1021/jacs.9b12571
Publikováno v:
Inorganic Chemistry. 58:15423-15432
The focus of this study is in the description of synthetic heme/copper/O2 chemistry employing a heme-containing binucleating ligand which provides a tridentate chelate for copper ion binding. The a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a458db430b0dea36fd91731964682aa8
https://doi.org/10.1021/acs.inorgchem.9b02521
https://doi.org/10.1021/acs.inorgchem.9b02521
Autor:
Edward I. Solomon, Daniel E. Diaz, Mayukh Bhadra, David A. Quist, Kenneth D. Karlin, Ioannis Kipouros, Andrew W. Schaefer, Austin E. Herzog
Publikováno v:
Angew Chem Int Ed Engl
The dioxygen reactivity of a series of TMPA-based copper(I) complexes (TMPA=tris(2-pyridylmethyl)amine), with and without secondary-coordination-sphere hydrogen-bonding moieties, was studied at -135 °C in 2-methyltetrahydrofuran (MeTHF). Kinetic sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02af730bf5d57d1933dce275c0235f
https://doi.org/10.1002/ange.201908471
https://doi.org/10.1002/ange.201908471
Autor:
Edward I. Solomon, Melanie A. Ehudin, Gregory L Schneider, David A. Quist, Kenneth D. Karlin, Andrew W. Schaefer
Publikováno v:
Journal of the American Chemical Society. 141:12682-12696
A superoxide-bridged dicopper(II) complex, [CuII2(XYLO)(O2•-)]2+ (1) (XYLO = binucleating m-xylyl derivative with a bridging phenolate ligand donor and two bis(2-{2-pyridyl}ethyl)amine arms), was generated from chemical oxidation of the peroxide-br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3d5b9289ad32592ef6b9af88868082
https://doi.org/10.1021/jacs.9b05277
https://doi.org/10.1021/jacs.9b05277
Publikováno v:
Journal of the American Chemical Society. 141:10068-10081
This study investigates the mechanism of O–O bond cleavage in heme-copper oxidase (HCO) enzymes, combining experimental and computational insights from enzyme intermediates and synthetic models. It is determined that HCOs undergo a proton-initiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5ffe63a48167614cd6a2399cbd9803
https://doi.org/10.1021/jacs.9b04271
https://doi.org/10.1021/jacs.9b04271
Autor:
Joel A. Tang, Edward I. Solomon, David A. Quist, Melanie A. Ehudin, Kenneth D. Karlin, Andrew W. Schaefer
Publikováno v:
Journal of the American Chemical Society. 141:4936-4951
Synthetic peroxo-bridged high-spin (HS) heme-(μ-η(2):η(1)-O(2)(2−))-Cu(L) complexes incorporating (as part of the copper ligand) intramolecular hydrogen-bond (H-bond) capabilities and/or steric effects are herein demonstrated to affect the compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c097b722950f3494d754aa767edd0d0
https://doi.org/10.1021/jacs.9b00118
https://doi.org/10.1021/jacs.9b00118
Autor:
Melanie A. Ehudin, Edward I. Solomon, Suzanne M. Adam, David A. Quist, Kenneth D. Karlin, Andrew W. Schaefer, Daniel E. Diaz, Joel A. Tang
Publikováno v:
Chemical Science. 10:2893-2905
Dioxygen reduction by heme–copper oxidases is a critical biochemical process, wherein hydrogen bonding is hypothesized to participate in the critical step involving the active-site reductive cleavage of the O–O bond. Sixteen novel synthetic heme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f297a6a9d1e3d2cf77bd134065c1b078
https://doi.org/10.1039/c8sc05165h
https://doi.org/10.1039/c8sc05165h
Autor:
Hyun Kim, Savita Sharma, Andrew W. Schaefer, Patrick J. Rogler, Kenneth D. Karlin, Edward I. Solomon
Publikováno v:
Angew Chem Int Ed Engl
A new end-on low-spin ferric heme peroxide, [(P(Im))Fe(III)─(O(2)(2−))](−) (P(Im)-P), and subsequently formed hydroperoxide species, [(P(Im))Fe(III)─(OOH)] (P(Im)-HP) are generated utilizing the iron-porphyrinate P(Im) with its tethered axial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f73f744fb11c947f2b84a7e005405c
https://europepmc.org/articles/PMC7920932/
https://europepmc.org/articles/PMC7920932/
Autor:
Cecile O Mejean, Andrew W Schaefer, Kenneth B Buck, Holger Kress, Alla Shundrovsky, Jason W Merrill, Eric R Dufresne, Paul Forscher
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73389 (2013)
Adhesions are multi-molecular complexes that transmit forces generated by a cell's acto-myosin networks to external substrates. While the physical properties of some of the individual components of adhesions have been carefully characterized, the mec
Externí odkaz:
https://doaj.org/article/9ff1ff5968064e8a8dcb607e34bcaed4