Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Andrew W, Gibson"'
Autor:
Rachel V. Jimenez, Tyler T. Wright, Nicholas R. Jones, Jianming Wu, Andrew W. Gibson, Alexander J. Szalai
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
C-reactive protein (CRP) is the prototypical acute phase reactant, increasing in blood concentration rapidly and several-fold in response to inflammation. Recent evidence indicates that CRP has an important physiological role even at low, baseline le
Externí odkaz:
https://doaj.org/article/1c3cbd2a1f1942b4a520d6f58a501078
Autor:
Lindsay L Waite, Benjamin eWeaver, Kenneth eDay, Xinrui eLi, Kevin eRoberts, Andrew W Gibson, Jeffrey C Edberg, Robert P Kimberly, Devin M Absher, Hemant K Tiwari
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
DNA methylation levels vary markedly by cell-type makeup of a sample. Understanding these differences and estimating the cell-type makeup of a sample is an important aspect of studying DNA methylation. DNA from leukocytes in whole blood is simple to
Externí odkaz:
https://doaj.org/article/a85ab6d985794e318ea7de25491bba07
Autor:
Yanfeng Zhang, Devin Absher, Xinrui Li, Robert P. Kimberly, Andrew W. Gibson, Jeffrey C. Edberg
Publikováno v:
Human molecular genetics. 29(15)
A common feature of autoimmune diseases, including systemic lupus erythematosus (SLE), is an increased prevalence in women. However, the molecular basis for sex disparity in SLE remains poorly understood. To examine the role of X-linked transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaf7b54bca0b8e1051120b1136f5afc
https://pubmed.ncbi.nlm.nih.gov/32628254
https://pubmed.ncbi.nlm.nih.gov/32628254
Autor:
Steven F. Oliver, Eric R. Ashley, Christopher Wise, Robert K. Orr, Eric B. Sirota, Rebecca T. Ruck, Joseph F. Leone, Jamie M. McCabe Dunn, Andrew Nolting, Andrew W. Gibson, Alan M. Hyde, Jon A. Jurica
Publikováno v:
Green Chemistry. 20:2519-2525
Herein we describe the route scouting and process development efforts toward a green and sustainable synthesis of the HCV NS5b cyclic prodrug nucleoside (CPN) 1. Through the discovery and development of a crystallization-induced dynamic resolution an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf888bc06ced66f7bc5ece659cc456ba
https://doi.org/10.1039/c8gc00102b
https://doi.org/10.1039/c8gc00102b
Autor:
Jianming Wu, Maureen H Richards, Jinhai Huang, Lena Al-Harthi, Xiulong Xu, Rui Lin, Fenglong Xie, Andrew W Gibson, Jeffrey C Edberg, Robert P Kimberly
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26143 (2011)
FasL expression on human immune cells and cancer cells plays important roles in immune homeostasis and in cancer development. Our previous study suggests that polymorphisms in the FasL promoter can significantly affect the gene expression in human ce
Externí odkaz:
https://doaj.org/article/196ad848a552447d811e6c6d9e85f662
Autor:
Robert A. Reamer, Jeffrey C. Moore, Stephen P. Keen, Lin Wang, Feng Peng, Billy Chen, Andrew W. Gibson, David R. Lieberman, David Murray, Kevin M. Belyk, Erika M. Milczek, Michael Williams, Ji Qi, Jongrock Kong, Lushi Tan, Mark McLaughlin, Zhiguo J. Song
Publikováno v:
Organic Letters. 19:926-929
An enantioselective synthesis of the potent anti-HIV nucleoside EFdA is presented. Key features of stereocontrol include construction of the fully substituted 4'-carbon via a biocatalytic desymmetrization of 2-hydroxy-2-((triisopropylsilyl)ethynyl)pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e08712d40da238e75392804655ffca0
https://doi.org/10.1021/acs.orglett.7b00091
https://doi.org/10.1021/acs.orglett.7b00091
Autor:
Varsolona Richard J, Jeremy P. Scott, Andrew W. Gibson, Lorenzo Codan, Xianliang He, Sophie Strickfuss, Lushi Tan, Alfred Y. Lee, Feng Wen, Wei Lin, Mark McLaughlin, Stephen P. Keen, Qinghao Chen, David R. Lieberman, Guiquan Liu, Mikhail Reibarkh, Spencer D. Dreher, Yan Jin, Michael Williams, Renee K. Dermenjian
Publikováno v:
Organic Process Research & Development. 20:1227-1238
We describe the route development and multikilogram-scale synthesis of an HCV NS5B site D inhibitor, MK-8876. The key topics covered are (1) process improvement of the two main fragments; (2) optimization of the initially troublesome penultimate step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faa863929f3ac296401789ae4c0011ea
https://doi.org/10.1021/acs.oprd.5b00405
https://doi.org/10.1021/acs.oprd.5b00405
Autor:
Andrew W. Gibson, Alexander J. Szalai, Tyler T. Wright, Nicholas R. Jones, Rachel V. Jimenez, Jianming Wu
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
C-reactive protein (CRP) is the prototypical acute phase reactant, increasing in blood concentration rapidly and several-fold in response to inflammation. Recent evidence indicates that CRP has an important physiological role even at low, baseline le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b830068fc625e74ca148dc86b48b3b
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00372/full
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00372/full
Autor:
Melissa E. Howard, Andrew W. Gibson, Alejandro Dieguez-Vazquez, Debra J. Wallace, Artis Klapars, Robert D. Wilson, Jeremy P. Scott, Peter R. Mullens, Andrew D. Gibb, Carl A. Baxter, Jaemoon Lee, Sarah E. Brewer, Stephen P. Keen, Ed Cleator, Nadine Bremeyer, Anthony Alorati, Kevin R. Campos, Matthew L. Maddess, Joseph J. Lynch, Jing Li
Publikováno v:
Organic Process Research & Development. 18:528-538
The development and execution of a practical asymmetric synthesis of the estrogen receptor beta selective agonist (8R,10aS)-6-(trifluoromethyl)-8,9,10,11-tetrahydro-8,10a-methanocyclohepta[1,2]indeno[4,5-d][1,2,3]triazol-7(3H)-one is described. The o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdefbcc65171430752e7a0100c3ac289
https://doi.org/10.1021/op5000489
https://doi.org/10.1021/op5000489
Autor:
Russell Lane, Isabelle Pénisson-Besnier, Wojtek Rakowicz, Charlotte K. Brierley, Cheryl Longman, Fiona Norwood, Andrew P. Jackson, Dieter Gläser, Matt Parton, Rumaisa Bashir, David Hilton-Jones, Debbie Hicks, Benedikt Schoser, Marcus Deschauer, Paul Maddison, John Nixon, Laura E. Rufibach, Meriel McEntagart, Isabel Illa, John McConville, Rita Barresi, John B Winer, Herbert Schreiber, Grainne S. Gorman, Laurence A. Bindoff, Christopher J Price, Hanns Lochmüller, Partha Ray, Simon Hammans, David Cottrell, Mark Roberts, Anthony H.V. Schapira, J. Hudson, Francesco Muntoni, Elizabeth Harris, Jay Panicker, Richard Walters, Ali Al-Memar, Robert G. Cooper, Esther Hwang, Sabine Krause, Pamela J. Shaw, Robert J. Swingler, Michelle Eagle, Bertold Schrank, Anna Sarkozy, Andrew W. Gibson, Maggie C. Walter, Richard E. Petty, Michael G. Hanna, Kathryn R. Wagner, Chris Turner, Peter Van den Bergh, Aijaz Khan, Geraldine Bailey, Michela Guglieri, NP Davies, Kate Bushby, Volker Straub, Jürgen Seeger, Liesbeth De Waele, Steve Laval, Douglass M. Turnbull
Publikováno v:
Human Mutation, Vol. 34, no.8, p. 1111-1118 (2013)
Human mutation, 2013, Vol.34(8), pp.1111-1118 [Peer Reviewed Journal]
HUMAN MUTATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Human mutation, 2013, Vol.34(8), pp.1111-1118 [Peer Reviewed Journal]
HUMAN MUTATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Limb girdle muscular dystrophy type 2L or anoctaminopathy is a condition mainly characterized by adult onset proximal lower limb muscular weakness and raised CK values, due to recessive ANO5 gene mutations. An exon 5 founder mutation (c.191dupA) has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3e6e91bac2c99f929b8cc933a27687
https://doi.org/10.1002/humu.22342
https://doi.org/10.1002/humu.22342