Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew V. Le"'
Autor:
Laura E. Niklason, Mervin C. Yoder, Alexander J. Engler, Yifan Yuan, Micha Sam Brickman Raredon, Andrew V. Le, Pavlina Baevova
Publikováno v:
Biomaterials. 200:25-34
Whole organ engineering paradigms typically involve repopulating acellular organ scaffolds with recipient-compatible cells, to generate a neo-organ that may provide key physiological functions. In the case of whole lung engineering, functionally endo
Autor:
Alexander J. Engler, Elizabeth A. Calle, Mahboobe Ghaedi, Laura E. Niklason, Pavlina Baevova, Arkadi Beloiartsev, Andrew V. Le, Go Hatachi
Publikováno v:
ACS biomaterials scienceengineering. 3(9)
To date, efforts to generate engineered lung tissue capable of long-term function have been limited by incomplete barrier formation between air and blood and by thrombosis of the microvasculature upon exposure of blood to the collagens within the dec
Autor:
S. Edelstein, Liping Zhao, Allison M. Greaney, Elise Gubbins, Laura E. Niklason, Andrew V. Le
Publikováno v:
C64. BIOENGINEERING AND LUNG REGENERATION.
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 12:e119-e129
In cellular, tissue-level or whole organ bioreactors, the level of dissolved oxygen is one of the most important factors requiring control. Hypoxic environments may lead to cellular apoptosis, while hyperoxic environments may lead to cellular damage
Autor:
Ashley L. Gard, Joseph A. Madri, Kirk C. Hansen, Katherine L. Leiby, Laura E. Niklason, Andrew V. Le, Elizabeth A. Calle, Ryan C. Hill
Publikováno v:
Acta Biomaterialia. 46:91-100
Extracellular matrix is a key component of many products in regenerative medicine. Multiple regenerative medicine products currently in the clinic are comprised of human or xenogeneic extracellular matrix. In addition, whole-organ regeneration exploi
Autor:
Yifan Yuan, Ellen L. Kan, Andrew V. Le, Pavlina Baevova, Alexander J. Engler, Yan A. Oczkowicz, Micha Sam Brickman Raredon, Laura E. Niklason
Publikováno v:
Biomaterials
Microvascular leak is a phenomenon witnessed in multiple disease states. In organ engineering, regaining a functional barrier is the most crucial step towards creating an implantable organ. All previous methods of measuring microvascular permeability
Autor:
Ashley L. Gard, Elise C. Wilcox, Rachel Dyal, Jonas Schwan, Eric S. White, Pavlina Baevova, Angela Liu, Huanxing Sun, Sashka Dimitrievska, Martin A. Schwartz, Laure Rittié, Laura E. Niklason, Andrew V. Le, Kristin A. Gerhold, Thomas J. Broekelmann, Sumati Sundaram, Liping Zhao, Robert P. Mecham, Jenna L. Balestrini
Publikováno v:
Biomaterials. 102:220-230
Lung engineering is a promising technology, relying on re-seeding of either human or xenographic decellularized matrices with patient-derived pulmonary cells. Little is known about the species-specificity of decellularization in various models of lun
Autor:
Mahboobe Ghaedi, Yibing Qyang, Amogh Sivarapatna, Laura E. Niklason, Julio J. Mendez, Andrew V. Le
Publikováno v:
Biomaterials. 53:621-633
Endothelial cells (ECs) exist in different microenvironments in vivo, including under different levels of shear stress in arteries versus veins. Standard stem cell differentiation protocols to derive ECs and EC-subtypes from human induced pluripotent
Autor:
Laura E. Niklason, Mahboobe Ghaedi, Pavlina Baevova, Rachel Dyal, Go Hatachi, Eric S. White, Julio J. Mendez, Amogh Sivarapatna, Kevin A. Rocco, Andrew V. Le, Arkadi Beloiartsev, Katie L. Leiby
Publikováno v:
Journal of tissue engineering and regenerative medicine. 12(3)
The development of an alternative source for donor lungs would change the paradigm of lung transplantation. Recent studies have demonstrated the potential feasibility of using decellularized lungs as scaffolds for lung tissue regeneration and subsequ
Autor:
Marjorie Gayanilo, Hrishikesh Thakur, Michael S. Kapiloff, Catherine L. Passariello, Joshua M. Hare, Joshua B. Danial, Andrew V. Le, André Hanauer, Jennifer J. Carlisle Michel, Alejandra Negro, Kimberly L. Dodge-Kafka, Michael D. Kritzer, Behzad N. Oskouei, Michael Sanders, Jinliang Li
Publikováno v:
Circulation Research. 112:128-139
Rationale: Cardiac myocyte hypertrophy is the main compensatory response to chronic stress on the heart. p90 ribosomal S6 kinase (RSK) family members are effectors for extracellular signal-regulated kinases that induce myocyte growth. Although increa