Microglia promote remyelination independent of their role in clearing myelin debris

Autor: Charbel S. Baaklini, Madelene F.S. Ho, Tristan Lange, Brady P. Hammond, Sharmistha P. Panda, Martin Zirngibl, Sameera Zia, Kassandre Himmelsbach, Heli Rana, Braxton Phillips, Daria Antoszko, Jeremies Ibanga, Mizuki Lopez, Kelly V. Lee, Michael B. Keough, Andrew V. Caprariello, Bradley J. Kerr, Jason R. Plemel

Publikováno v: Cell Reports, Vol 42, Iss 12, Pp 113574- (2023)

Summary: Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination. Remyelination, linked to reduced disability in MS, relies on micr

Externí odkaz: https://doaj.org/article/c6101db6703e4244b13c710b42e758bc

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Autor: Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello, Jason R. Plemel

Publikováno v: Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-28 (2022)

Abstract Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis. Despite the extensive use of cuprizone, the

Externí odkaz: https://doaj.org/article/d8faa4df16704c57987d5fda2843ed3a

Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity

Autor: Peter K. Stys, Antonio Luchicchi, Geert J. Schenk, Andrew V. Caprariello, Jeroen J. G. Geurts, Jeffrey T. Joseph, Wulin Teo, Megan L. Morgan

Publikováno v: Proc Natl Acad Sci U S A
Teo, W, Caprariello, A V, Morgan, M L, Luchicchi, A, Schenk, G J, Joseph, J T, Geurts, J J G & Stys, P K 2021, ' Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 8, e2016897118 . https://doi.org/10.1073/pnas.2016897118
Proceedings of the National Academy of Sciences of the United States of America, 118(8):e2016897118. National Academy of Sciences

The molecular composition of myelin membranes determines their structure and function. Even minute changes to the biochemical balance can have profound consequences for axonal conduction and the synchronicity of neural networks. Hypothesizing that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a536e5cb8a170446fd70ded2736783
https://europepmc.org/articles/PMC7923366/

Autofluorescence spectroscopy as a proxy for chronic white matter pathology

Autor: Andrew V. Caprariello, Megan L. Morgan, Peter K. Stys, Deepak Kumar Kaushik

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England). 27(7)

Background: The balance of tissue injury and repair ultimately determines outcomes of chronic neurological disorders, such as progressive multiple sclerosis (MS). However, the extent of pathology can be difficult to detect, particularly when it is in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43816efda7c64a7db50d159ab7a6cf0
https://pubmed.ncbi.nlm.nih.gov/32779553

Biochemically altered myelin triggers autoimmune demyelination

Autor: Shigeki Tsutsui, Andrew V. Caprariello, Vahid Hoghooghi, Megan L. Morgan, Jason R. Plemel, Adam Koebel, James A. Rogers, Peter K. Stys, Jeff F. Dunn, Shalina S. Ousman, Lakshmi P. Kotra, V. Wee Yong

Publikováno v: Proceedings of the National Academy of Sciences. 115:5528-5533

Although immune attack against central nervous system (CNS) myelin is a central feature of multiple sclerosis (MS), its root cause is unresolved. In this report, we provide direct evidence that subtle biochemical modifications to brain myelin elicit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d354346cfe6f5e358da83ed17962c271
https://doi.org/10.1073/pnas.1721115115