Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Andrew V, Samuelson"'
Autor:
Maria I Lazaro-Pena, Adam B Cornwell, Carlos A Diaz-Balzac, Ritika Das, Zachary C Ward, Nicholas Macoretta, Juilee Thakar, Andrew V Samuelson
Publikováno v:
eLife, Vol 12 (2023)
Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an
Externí odkaz:
https://doaj.org/article/c298475de3254457ae6029f66836d12b
HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network
Autor:
Maria I. Lazaro-Pena, Zachary C. Ward, Sifan Yang, Alexandra Strohm, Alyssa K. Merrill, Celia A. Soto, Andrew V. Samuelson
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Discoveries made in the nematode Caenorhabditis elegans revealed that aging is under genetic control. Since these transformative initial studies, C. elegans has become a premier model system for aging research. Critically, the genes, pathways, and pr
Externí odkaz:
https://doaj.org/article/3518703fb6c7441ca904dcc0299d11cc
Autor:
Adam Cornwell, Jesse R. Llop, Peter Salzman, Niels Rasmussen, Juilee Thakar, Andrew V. Samuelson
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The advent of feeding based RNAi in Caenorhabditis elegans led to an era of gene discovery in aging research. Hundreds of gerogenes were discovered, and many are evolutionarily conserved, raising the exciting possibility that the underlying genetic b
Externí odkaz:
https://doaj.org/article/b774c9e188aa4374992d9d3fbbac12c7
Autor:
Maria I. Lazaro-Pena, Adam B. Cornwell, Carlos A. Diaz-Balzac, Ritika Das, Nicholas Macoretta, Juilee Thakar, Andrew V. Samuelson
Publikováno v:
bioRxiv
Aging and the age-associated decline of the proteome is determined in part through neuronal control of evolutionarily conserved transcriptional effectors, which safeguard homeostasis under fluctuating metabolic and stress conditions by regulating an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfaf4d238e8e20fe6cde6736ae821a4
https://doi.org/10.1101/2023.01.11.523661
https://doi.org/10.1101/2023.01.11.523661
Autor:
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007038 (2017)
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding w
Externí odkaz:
https://doaj.org/article/944a8ce4a5f7455e8e44dd3caf07d459
The nervous system systemically coordinates proteostasis to delay organismal aging. However, the neuronal regulatory mechanisms that coordinate cellular anti-aging programs across tissue and cell-types are relatively unknown. In this work, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c6760136ba421fa21e65bb792c64c8
https://doi.org/10.1101/2022.04.02.486836
https://doi.org/10.1101/2022.04.02.486836
Publikováno v:
Journal of Visualized Experiments.
The ability to maintain proper function and folding of the proteome (protein homeostasis) declines during normal aging, facilitating the onset of a growing number of age-associated diseases. For instance, proteins with polyglutamine expansions are pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ebf120f9446e9f110abf1054cb1fc2
https://doi.org/10.3791/61100-v
https://doi.org/10.3791/61100-v
Autor:
David W Johnson, Jesse R Llop, Sara F Farrell, Jie Yuan, Lindsay R Stolzenburg, Andrew V Samuelson
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004278 (2014)
The Myc family of transcription factors regulates a variety of biological processes, including the cell cycle, growth, proliferation, metabolism, and apoptosis. In Caenorhabditis elegans, the "Myc interaction network" consists of two opposing heterod
Externí odkaz:
https://doaj.org/article/9744c6b641514d79967098ddb30f86d4
Autor:
Andrew V. Samuelson, Adam Cornwell
Publikováno v:
Aging ISBN: 9781071605912
Methods Mol Biol
Methods Mol Biol
Lifespan is the most straightforward surrogate measure of aging, as it is easily quantifiable. A common approach to measure Caenorhabditis elegans lifespan is to follow a population of animals over time and score viability based on movement. We previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745e86b04224eb4198881dc4c0330714
https://doi.org/10.1007/978-1-0716-0592-9_2
https://doi.org/10.1007/978-1-0716-0592-9_2
Publikováno v:
J Vis Exp
The Replica Set method is an approach to quantitatively measure lifespan or survival of Caenorhabditis elegans nematodes in a high-throughput manner, thus allowing a single investigator to screen more treatments or conditions over the same amount of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d89e9b3bcb4593b8d78ad5d706a8dcf
https://pubmed.ncbi.nlm.nih.gov/30010651
https://pubmed.ncbi.nlm.nih.gov/30010651