Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrew Tilston‐Lunel"'
Autor:
Erin Crossey, Senegal Carty, Fengzhi Shao, Jhonatan Henao-Vasquez, Alexandra B. Ysasi, Michelle Zeng, Anne Hinds, Ming Lo, Andrew Tilston-Lunel, Xaralabos Varelas, Matthew R. Jones, Alan Fine
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The lymphatic system consists of a vessel network lined by specialized lymphatic endothelial cells (LECs) that are responsible for tissue fluid homeostasis and immune cell trafficking. The mechanisms for organ-specific LEC responses to envir
Externí odkaz:
https://doaj.org/article/d1b0a87cde6e49948d29b487f65ded98
Autor:
Ahmed A. Raslan, Tho X. Pham, Jisu Lee, Konstantinos Kontodimas, Andrew Tilston-Lunel, Jillian Schmottlach, Jeongmin Hong, Taha Dinc, Andreea M. Bujor, Nunzia Caporarello, Aude Thiriot, Ulrich H. von Andrian, Steven K. Huang, Roberto F. Nicosia, Maria Trojanowska, Xaralabos Varelas, Giovanni Ligresti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Progressive lung fibrosis is associated with poorly understood aging-related endothelial cell dysfunction. To gain insight into endothelial cell alterations in lung fibrosis we performed single cell RNA-sequencing of bleomycin-injured lungs
Externí odkaz:
https://doaj.org/article/93d336e7cfe145a0ab25d328dca7bbca
Autor:
Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma
Externí odkaz:
https://doaj.org/article/f742ba331c9e4c36a7f1fe1c4bdef362
Autor:
Ariana Dela Cruz, Vinay Kartha, Andrew Tilston-Lunel, Rongjuan Mi, Taylor L. Reynolds, Michael Mingueneau, Stefano Monti, Janicke L. Jensen, Kathrine Skarstein, Xaralabos Varelas, Maria A. Kukuruzinska
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Sjögren’s syndrome (SS) is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Although the etiology of SS remains unclear, evidence suggests that epithelial dam
Externí odkaz:
https://doaj.org/article/78b4ac9190c74b908615a330e8a4a60e
Autor:
Julia Hicks-Berthet, Boting Ning, Anthony Federico, Andrew Tilston-Lunel, Adeline Matschulat, Xingbin Ai, Marc E. Lenburg, Jennifer Beane, Stefano Monti, Xaralabos Varelas
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109347- (2021)
Summary: Proper lung function relies on the precise balance of specialized epithelial cells that coordinate to maintain homeostasis. Herein, we describe essential roles for the transcriptional regulators YAP/TAZ in maintaining lung epithelial homeost
Externí odkaz:
https://doaj.org/article/51d769715d5644f496c2be0ccf9745a0
Autor:
Nils M. Kronenberg, Andrew Tilston-Lunel, Frances E. Thompson, Doris Chen, Wanjia Yu, Kishan Dholakia, Malte C. Gather, Frank J. Gunn-Moore
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Willin/FRMD6 is part of a family of proteins with a 4.1 ezrin-radixin-moesin (FERM) domain. It has been identified as an upstream activator of the Hippo pathway and, when aberrant in its expression, is associated with human diseases and disorders. Ev
Externí odkaz:
https://doaj.org/article/810fe848f8e84347b5596fd3f2b2ab06
Autor:
Takanobu Shirai, Miho Sekai, Kei Kozawa, Nanami Sato, Nobuyuki Tanimura, Shunsuke Kon, Tomohiro Matsumoto, Takeru Murakami, Shoko Ito, Andrew Tilston‐Lunel, Xaralabos Varelas, Yasuyuki Fujita
Publikováno v:
Cancer Science. 113:3710-3721
At the initial stage of carcinogenesis, oncogenic transformation occurs in single cells within epithelial layers. However, the behavior and fate of the newly emerging transformed cells remain enigmatic. Here, using originally established mouse models
Autor:
Joseph Kern, Andrew Tilston-Lunel, Anthony Federico, Boting Ning, Grace Peppler, Eleni Stampouloglou, Marc Lenburg, Jennifer Beane, Stefano Monti, Xaralabos Varelas
Publikováno v:
Cancer Research. 82:P2-05
Basal-like breast cancers, an aggressive breast cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells but undergo plasticity to a basal-like state upon transformation. Identifying cellular mechanis
Autor:
Rui Hong, Shayna McDonald, Xiaowei Xu, Craig J. Ceol, Joshua D. Campbell, Andrew Tilston Lunel, Marc A. Vittoria, Xaralabos Varelas, Neil J. Ganem, Eric Xia, Lee Huang, Revati Darp, Nathan M Kingston, Deborah Lang
Human melanomas are commonly driven by activating mutations in BRAF, which promote melanocyte proliferation through constitutive stimulation of the MAPK pathway. However, oncogenic BRAF alone is insufficient to promote melanoma; instead, its expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf851771f22317578da574a96f97929
https://doi.org/10.1101/2021.05.04.442615
https://doi.org/10.1101/2021.05.04.442615
Autor:
Matthew D. Layne, Andrew Tilston-Lunel, Kathleen Desevin, Anna C. Belkina, Nabil Rabhi, Stephen R. Farmer, Xaralabos Varelas
Publikováno v:
SSRN Electronic Journal.
Adipose tissue fibrosis is regulated by the chronic and progressive metabolic imbalance caused by differences in caloric intake and energy expenditure. By exploring the cellular heterogeneity within fibrotic adipose tissue, we demonstrate that early