Abstract P104: Simultaneous Treatment With Ivabradine And Spironolactone Does Not Modify Hypertension-induced Myocardial Fibrosis In Dahl Salt-sensitive Rats

Autor: Eduard I. Dedkov, Andrew T. Milcarek

Publikováno v: Hypertension. 78

Background: Hypertension (HT)-induced accumulation of myocardial collagen stiffens the left ventricular (LV) wall and, hence, promotes diastolic dysfunction. Considering that a competitive aldosterone receptor antagonist spironolactone (SL) as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec03f11b1e71e6124889124a47c24e6d
https://doi.org/10.1161/hyp.78.suppl_1.p104

Abstract 323: Gamma-Enolase in Adult Cardiac Myocytes: A Study of Subcellular Localization and Post-Myocardial Infarction Modulation

Autor: Eduard I. Dedkov, Andrew T. Milcarek

Publikováno v: Circulation Research. 127

Background: Gamma-enolase, or neuron-specific enolase, is a multifunctional protein which is primarily found in neurons and neuroendocrine cells. Although the main role of gamma-enolase is associated with enzymatic activity during aerobic glycolysis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::639eae33d50707dede5475c1e17beb8e
https://doi.org/10.1161/res.127.suppl_1.323

Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer

Autor: Mary L. Alpaugh, Aspen L. Settle, Maria A. Theodoraki, Andrew T. Milcarek, Bashayer D. Althufairi, Oraphin Chantarasriwong, Theodore Habarth Morales, Emmanuel A. Theodorakis, Celso O. Rezende

Publikováno v: Chantarasriwong, Oraphin; Milcarek, Andrew T; Morales, Theodore Habarth; Settle, Aspen L; Rezende, Celso O; Althufairi, Bashayer D; et al.(2019). Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer.. European journal of medicinal chemistry, 168, 405-413. doi: 10.1016/j.ejmech.2019.02.047. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/70s1j4tz

Inflammatory breast cancer (IBC) is a highly metastatic, lethal form of breast cancer that lacks targeted therapeutic strategies. Inspired by the promising cytotoxicity of gambogic acid and related caged xanthones in spheroidsMARY-X, an in vitro prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b864639fad2ab385e5b8850be5ccba74
https://pubmed.ncbi.nlm.nih.gov/30831408