Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrew T. Krueger"'
Autor:
Timur Rusanov, Eric T. Kool, Willem A. Velema, Richard T. Pomerantz, Andrew T. Krueger, Trung M. Hoang, Tatiana Kent, William C. Copeland
Publikováno v:
Nucleic Acids Research
DNA polymerase θ (Polθ) is a unique A-family polymerase that is essential for alternative end-joining (alt-EJ) of double-strand breaks (DSBs) and performs translesion synthesis. Because Polθ is highly expressed in cancer cells, confers resistance
Autor:
Carsten Kroll, Andrew T. Krueger, Christi D. Cook, Caroline C. Ahrens, Elena Cambria, Linda G. Griffith, Barbara Imperiali, Kasper Renggli
Publikováno v:
Biomacromolecules
Synthetic extracellular matrices are widely used in regenerative medicine and as tools in building in vitro physiological culture models. Synthetic hydrogels display advantageous physical properties, but are challenging to modify with large peptides
Publikováno v:
PMC
Described is the development and application of a versatile semisynthetic strategy, based on a combination of sortase-mediated coupling and tetrazine ligation chemistry, which can be exploited for the efficient incorporation of tunable functionality
Publikováno v:
Nucleic Acids Research
Template independent polymerases, and terminal deoxynucleotidyl transferase (TdT) in particular, have been widely used in enzymatic labeling of DNA 3'-ends, yielding fluorescently-labeled polymers. The majority of fluorescent nucleotides used as TdT
Autor:
Barbara Imperiali, Andrew T. Krueger
Publikováno v:
ChemInform. 44
Fluorescence spectroscopy is a powerful tool for probing complex biological processes. The ubiquity of peptide-protein and protein-protein interactions in these processes has made them important targets for fluorescence labeling, and to allow sensiti
Autor:
Barbara Imperiali, Andrew T. Krueger
Publikováno v:
Imperiali via Courtney Crummett
Fluorescence spectroscopy is a powerful tool for probing complex biological processes. The ubiquity of peptide-protein and protein-protein interactions in these processes has made them important targets for fluorescence labeling, and to allow sensiti
Autor:
Eric T. Kool, Larryn W. Peterson, Andrew T. Krueger, Jijumon Chelliserry, Daniel J. Kleinbaum
An unnatural base-pair architecture with base pairs 2.4 Å larger than the natural DNA-based genetic system (xDNA) is evaluated for its ability to function like DNA, encoding amino acids in the context of living cells. xDNA bases are structurally ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51af013c60491a36b5cfe8601b5f5b8e
https://europepmc.org/articles/PMC3255458/
https://europepmc.org/articles/PMC3255458/
Autor:
Eric T. Kool, Andrew T. Krueger
Recognition of the nucleic acid bases within the DNA scaffold comprises the basis for transmission of genetic information, dictating protein and cell assembly, organismal development, and evolution. Driven in part by the need to test our current unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305e048fd29c4b6871aa0610d2a911a3
https://europepmc.org/articles/PMC2693216/
https://europepmc.org/articles/PMC2693216/
Autor:
Eric T. Kool, Andrew T. Krueger
Publikováno v:
Journal of the American Chemical Society. 130(12)
We recently described the synthesis and helix assembly properties of expanded DNA (xDNA), which contains base pairs 2.4 A larger than natural DNA pairs. This designed genetic set is under study with the goals of mimicking the functions of the natural
Autor:
Andrew T. Krueger, Eric T. Kool
The fact that nucleic acid bases recognize each other to form pairs is a canonical part of the dogma of biology. However, they do not recognize each other well enough in water to account for the selectivity and efficiency that is needed in the transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1c226afd18dbf64df721901e1b0152
https://europepmc.org/articles/PMC2175026/
https://europepmc.org/articles/PMC2175026/