Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Andrew T. Holdbrooks"'
Autor:
Colleen M. Britain, Andrew T. Holdbrooks, Joshua C. Anderson, Christopher D. Willey, Susan L. Bellis
Publikováno v:
Journal of Ovarian Research, Vol 11, Iss 1, Pp 1-11 (2018)
Abstract Background The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various malignancies, including ovarian cancer. Through its sialylation of a select co
Externí odkaz:
https://doaj.org/article/c388b79a71294f0cacdb4226a10c81b3
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241850 (2020)
The ST6Gal-I sialyltransferase, an enzyme that adds α2-6-linked sialic acids to N-glycosylated proteins, regulates multiple immunological processes. However, the contribution of receptor sialylation to inflammatory signaling has been under-investiga
Externí odkaz:
https://doaj.org/article/8c5bddeff390480cb8fe5b3b89f7ddfd
Autor:
Steffanie Sabbaj, Yudong Liu, Hongwei Qin, Braden C. McFarland, Amber L. Rowse, Laurie E. Harrington, Chander Raman, Patrizia De Sarno, Andrew T. Holdbrooks, Lora L. Yanagisawa, Etty N. Benveniste
Publikováno v:
The Journal of Immunology. 192:59-72
Pathogenic Th cells and myeloid cells are involved in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The JAK/STAT pathway is used by numerous cytokines for signaling and is crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8378095496bce044312d40591d35142b
https://doi.org/10.4049/jimmunol.1301513
https://doi.org/10.4049/jimmunol.1301513
Publikováno v:
The Journal of Immunology. 190:372-380
Inflammation in the CNS contributes to neurologic disorders. Neuroinflammation involves the release of inflammatory molecules from glial cells, such as astrocytes and microglia, and can lead to neuronal damage if unabated. In multiple sclerosis, peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8388a03fbee9db92f4afbb28586d5f
https://doi.org/10.4049/jimmunol.1202390
https://doi.org/10.4049/jimmunol.1202390
Autor:
Etty N. Benveniste, Andrew T. Holdbrooks, Yudong Liu, Hongwei Qin, Lora L. Yanagisawa, Stephanie L. Reynolds
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(1)
Macrophages participate in both the amplification of inflammation at the time of injury, and downregulation of the inflammatory response to avoid excess tissue damage. These divergent functions of macrophages are dictated by their microenvironment, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b014a2853f4c3bd2df12805e993dd8
https://pubmed.ncbi.nlm.nih.gov/22925925
https://pubmed.ncbi.nlm.nih.gov/22925925
Autor:
Yudong Liu, Hongwei Qin, Stephanie L. Reynolds, Andrew T. Holdbrooks, Lora L. Yanagisawa, Etty N. Benveniste
Publikováno v:
The Journal of Immunology. 189:3439-3448
Macrophages participate in both the amplification of inflammation at the time of injury and downregulation of the inflammatory response to avoid excess tissue damage. These divergent functions of macrophages are dictated by their microenvironment, es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3690e78fdb47e90ca802b1c85889b6
https://doi.org/10.4049/jimmunol.1201168
https://doi.org/10.4049/jimmunol.1201168
Publikováno v:
Cancer Research. 78:2334-2334
Studies have well-established that activation of TNFR1, a ubiquitously expressed cell surface receptor, by TNF can induce either cell survival or cell death signaling cascades, however, the mechanisms regulating TNFR1 to initiate these disparate outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954e677486cd2efa1440a4e4527e31b6
https://doi.org/10.1158/1538-7445.am2018-2334
https://doi.org/10.1158/1538-7445.am2018-2334
Publikováno v:
Cancer Research. 78:2504-2504
The Epidermal Growth Factor Receptor (EGFR) is one of the most commonly altered receptors in cancer. In the present study, we report that sialylation of EGFR by the tumor-associated sialyltransferase ST6Gal-I increases receptor activation resulting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a63341748a46368cf84894dcb9a33c1
https://doi.org/10.1158/1538-7445.am2018-2504
https://doi.org/10.1158/1538-7445.am2018-2504
Autor:
Jessica Buckley, Yudong Liu, Hongwei Qin, Andrew T. Holdbrooks, Etty N. Benveniste, Gordon P. Meares
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(3)
The JAK/STAT pathway is critical for development, regulation, and termination of immune responses, and dysregulation of the JAK/STAT pathway, that is, hyperactivation, has pathological implications in autoimmune and neuroinflammatory diseases. Suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccf877f5938593dee7fa65beba8123d
https://pubmed.ncbi.nlm.nih.gov/26085687
https://pubmed.ncbi.nlm.nih.gov/26085687
Autor:
Charles N. Landen, Chris A. Klug, Robert A. Kesterson, Andrew T. Holdbrooks, Susan L. Bellis, Matthew J. Schultz, Rebecca C. Arend, Michael G. Conner, Asmi Chakraborty, Patsy G. Oliver, Donald J. Buchsbaum, Karina J. Yoon, Amber K. O'Connor, Bradley K. Yoder, Daniel C. Bullard, William E. Grizzle
Publikováno v:
Cancer Research. 76:3327-3327
Altered glycosylation is a key hallmark of tumor cells; still, the role of individual glycosyltransferases remains unclear. ST6Gal-I is a tumor-associated sialyltransferase which catalyzes the addition of a sialic acid sugar to substrate glycoprotein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eed36fa40a2fd9790388b28a01615a39
https://doi.org/10.1158/1538-7445.am2016-3327
https://doi.org/10.1158/1538-7445.am2016-3327