Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew T. Bruce"'
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Selected renal cells (SRCs), a renal epithelial cell-enriched platform, are being advanced as an autologous cell-based therapy for the treatment of chronic kidney disease. However, the mechanism underlying its renal reparative and restorative effects
Externí odkaz:
https://doaj.org/article/feaddc3e80ea4292af5a8f355ceb5778
Autor:
Joydeep Basu, Christopher W. Genheimer, Elias A. Rivera, Richard Payne, Kim Mihalko, Kelly Guthrie, Andrew T. Bruce, Neil Robbins, Darell McCoy, Namrata Sangha, Roger Ilagan, Toyin Knight, Thomas Spencer, Belinda J. Wagner, Manuel J. Jayo, Deepak Jain, John W. Ludlow, Craig Halberstadt
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Development of a tissue-engineered neo-kidney augment (NKA) requires evaluation of defined, therapeutically relevant cell and cell/biomaterial composites (NKA constructs) for regenerative potential in mammalian kidney. Previous work identified primar
Externí odkaz:
https://doaj.org/article/bd194db3126b4b58987ba07704a3e24c
Autor:
Belinda J. Wagner, Christopher W. Genheimer, Eric S. Werdin, John W. Ludlow, Elias A. Rivera, Andrew T. Bruce, Bryan R. Cox, Timothy A. Bertram, Kelly I. Guthrie, Patricia Tatsumi-Ficht, Russell W. Kelley, Roger M. Ilagan, Shay M. Wallace, Manuel J. Jayo, Sumana Choudhury, Sharon C. Presnell
Publikováno v:
Tissue Engineering Part C: Methods. 17:261-273
Chronic kidney disease (CKD) is a global health problem; the growing gap between the number of patients awaiting transplant and organs actually transplanted highlights the need for new treatments to restore renal function. Regenerative medicine is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477aebdf7dcd7c35df6faa6084dfac46
https://doi.org/10.1089/ten.tec.2010.0399
https://doi.org/10.1089/ten.tec.2010.0399
Autor:
Sarah F. Quinlan, John W. Ludlow, Jacob E. Shokes, Roger M. Ilagan, Chistopher W. Genheimer, Kelly I. Guthrie, Teresa Burnette, Andrew T. Bruce, Namrata Sangha, Joydeep Basu
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 19:184-189
Bladder tissue has been regenerated in humans with neurogenic bladder using an implant produced from autologous urothelial (UC) and smooth muscle cells (SMC) expanded from bladder biopsies seeded onto a biodegradable synthetic scaffold. As the majori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88f14ccf178759e5603699a2fd07f66
https://doi.org/10.1097/pai.0b013e3181f09311
https://doi.org/10.1097/pai.0b013e3181f09311
Autor:
Sumana Choudhury, Timothy A. Bertram, Andrew T Bruce, Thomas Spencer, Joydeep Basu, Elias Rivera, Deepak Jain, Russell W. Kelley, Namrata Sangha, Roger M. Ilagan, Kelly I. Guthrie
Publikováno v:
Regenerative medicine. 10(7)
Aim: Identification of mechanistic pathways for selected renal cell (SRC) therapeutic bioactivity in rodent models of chronic kidney disease. Materials & methods: In vivo and in vitro functional bioassays applied to investigate regenerative outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d10d2a31512bb3bbc5ad2fe9a44ea2
https://pubmed.ncbi.nlm.nih.gov/26568079
https://pubmed.ncbi.nlm.nih.gov/26568079
Publikováno v:
Molecular Therapy. 5:716-722
Adeno-associated virus (AAV) is a useful vector for hemophilia gene therapy, but the limited effective packaging capacity of AAV (5 kb) appears to be incompatible with factor VIII (gene symbol F8) cDNA (7 kb). Although we previously demonstrated effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3d0ef476029c924190fb363023759d
https://doi.org/10.1006/mthe.2002.0607
https://doi.org/10.1006/mthe.2002.0607
Publikováno v:
Blood. 95:1594-1599
Persistent therapeutic levels of human factor VIII (hFVIII) would signify a major advance in the treatment of hemophilia A. Here we report sustained expression of hFVIII in immunocompetent mice using recombinant adeno-associated virus (rAAV) vectors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::129ccfbdecf099f937c1904bd728d8d6
https://doi.org/10.1182/blood.v95.5.1594.005k34_1594_1599
https://doi.org/10.1182/blood.v95.5.1594.005k34_1594_1599
Publikováno v:
Journal of Neuroscience Research. 55:504-513
To explore the feasibility of cell type-specific gene expression in oligodendrocytes as a possible therapeutic approach for demyelinating diseases, the cell specificity, tissue specificity, and duration of gene expression were investigated using reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccc1e1047d10f4961a0f569981387c6d
https://doi.org/10.1002/(sici)1097-4547(19990215)55:4<504::aid-jnr10>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19990215)55:4<504::aid-jnr10>3.0.co
Autor:
Eric S. Werdin, Anjali N. Rao, Thomas Spencer, Benjamin D. Humphreys, Sumana Choudhury, Rusty Kelley, Fengfeng Xu, Manuel J. Jayo, Sharon C. Presnell, Tim Bertram, Kelly I. Guthrie, Shay M. Wallace, Andrew T. Bruce, Elias A. Rivera, Roger M. Ilagan
Publikováno v:
Cell Transplantation, Vol 22 (2013)
New treatment paradigms that slow or reverse progression of chronic kidney disease (CKD) are needed to relieve significant patient and healthcare burdens. We have shown that a population of selected renal cells (SRCs) stabilized disease progression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a617da70362e513fe6dc0de3f70464
https://doaj.org/article/7ca09f8c5c4946ad93f5e619fe9d10b5
https://doaj.org/article/7ca09f8c5c4946ad93f5e619fe9d10b5
Publikováno v:
Trends in biotechnology. 31(9)
Methodologies for the rigorous and quantitative evaluation of biological activity or potency are an essential aspect of the developmental pathway for all biologic product candidates. Such assays typically leverage key mechanistic pathways demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031c86ef99d1afcd68e0421303f95c77
https://pubmed.ncbi.nlm.nih.gov/23932143
https://pubmed.ncbi.nlm.nih.gov/23932143