Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrew T Moehlman"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010828 (2023)
The early pathogenesis and underlying molecular causes of motor neuron degeneration in Parkinson's Disease (PD) remains unresolved. In the model organism Drosophila melanogaster, loss of the early-onset PD gene parkin (the ortholog of human PRKN) res
Externí odkaz:
https://doaj.org/article/735bdcfb4eb74d07adfba1123831897b
Publikováno v:
eLife, Vol 7 (2018)
In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. Among these pathways, the Unfolded Protein Response protects cells from the accumulation of misfolded proteins in t
Externí odkaz:
https://doaj.org/article/326920b5f36f4943ba8526deffaed516
Publikováno v:
eLife, Vol 4 (2015)
Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How car
Externí odkaz:
https://doaj.org/article/1d3c7261ab454f7e97a957a5b84a2ce6
Autor:
David Prokai, Ashutosh Pudasaini, Mohammed Kanchwala, Andrew T. Moehlman, Alexandrea E. Waits, Karen M. Chapman, Jaideep Chaudhary, Jesus Acevedo, Patrick Keller, Xing Chao, Bruce R. Carr, F. Kent Hamra
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101880- (2021)
Summary: In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogo
Externí odkaz:
https://doaj.org/article/7a851f768b5b49019ec1a24e649bc647
Autor:
Shashank Shekhar, Andrew T. Moehlman, Brenden Park, Michael Ewnetu, Charles Tracy, Iris Titos, Krzysztof Pawłowski, Vincent S. Tagliabracci, Helmut Krämer
Publikováno v:
Nature Communications. 14
In nervous systems, retrograde signals are key for organizing circuit activity and maintaining neuronal homeostasis. We identify the conserved Allnighter (Aln) pseudokinase as a cell non-autonomous regulator of proteostasis responses necessary for no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4ce188facc22ebef78606033c57ae8
https://doi.org/10.1038/s41467-023-38485-7
https://doi.org/10.1038/s41467-023-38485-7
Autor:
Amanda K. Casey, Hillery F. Gray, Suneeta Chimalapati, Genaro Hernandez, Andrew T. Moehlman, Nathan Stewart, Hazel A. Fields, Burak Gulen, Kelly A. Servage, Karoliina Stefanius, Aubrie Blevins, Bret M. Evers, Helmut Krämer, Kim Orth
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The proper balance of synthesis, folding, modification, and degradation of proteins, also known as protein homeostasis, is vital to cellular health and function. The unfolded protein response (UPR) is activated when the mechanisms maintaining protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a7572e9a56427de8aab757ba238a25
https://doi.org/10.1073/pnas.2208317119
https://doi.org/10.1073/pnas.2208317119
Autor:
Andrew T. Moehlman, David Prokai, Jaideep Chaudhary, Ashutosh Pudasaini, Alexandrea E. Waits, Patrick W. Keller, Mohammed Kanchwala, F. Kent Hamra, Karen M. Chapman, Jesus F. Acevedo, Bruce R. Carr, Xing Chao
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101880-(2021)
iScience, Vol 24, Iss 1, Pp 101880-(2021)
Summary In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5088fed42a11182e6e0b7c0c59ef568
http://europepmc.org/articles/PMC7797946
http://europepmc.org/articles/PMC7797946
Autor:
Richard J. Youle, Andrew T Moehlman
Publikováno v:
Annual review of cell and developmental biology. 36
Maintaining mitochondrial health is essential for the survival and function of eukaryotic organisms. Misfunctioning mitochondria activate stress-responsive pathways to restore mitochondrial network homeostasis, remove damaged or toxic proteins, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef497dc4a8a3ef19a6c6d6b0b1ab5de
https://pubmed.ncbi.nlm.nih.gov/33021820
https://pubmed.ncbi.nlm.nih.gov/33021820
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
The Drosophila Ncc69 gene encodes a Na+-K+-2Cl−-cotransporter (NKCC) that is critical for regulating intra- and extracellular ionic conditions in different tissues. Here, we show that the Ncc69 transporter is necessary for fly vision and that its e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f21c98154edfed4e7bfb999e483808
https://pubmed.ncbi.nlm.nih.gov/30792494
https://pubmed.ncbi.nlm.nih.gov/30792494
