Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew T Hutchinson"'
Autor:
Maria E Lund, Bronwyn A O'Brien, Andrew T Hutchinson, Mark W Robinson, Ann M Simpson, John P Dalton, Sheila Donnelly
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86289 (2014)
Infections with helminth parasites prevent/attenuate auto-inflammatory disease. Here we show that molecules secreted by a helminth parasite could prevent Type 1 Diabetes (T1D) in nonobese diabetic (NOD) mice. When delivered at 4 weeks of age (coincid
Externí odkaz:
https://doaj.org/article/caff9c70f6774635b63afd1dd98d17d6
Autor:
Mark W Robinson, Sheila Donnelly, Andrew T Hutchinson, Joyce To, Nicole L Taylor, Raymond S Norton, Matthew A Perugini, John P Dalton
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002042 (2011)
Over the last decade a significant number of studies have highlighted the central role of host antimicrobial (or defence) peptides in modulating the response of innate immune cells to pathogen-associated ligands. In humans, the most widely studied an
Externí odkaz:
https://doaj.org/article/b058d9f038fc40e09234c67174aa24b4
Autor:
Natsuo Yamamoto, W Ptak, Thomas Groot Kormelink, Henk Van Loveren, Regis A. Campos, Steven M. Kerfoot, Krzysztof Bryniarski, P W Askenase, Katarzyn Nazimek, Vipin Paliwal, Andrew T. Hutchinson, Frank A. Redegeld, Monika Majewska-Szczepanik, Marian Szczepanik, Atsuko Itakura
Publikováno v:
Annals of the New York Academy of Sciences. 1362:200-214
We propose that there is a special B-1a B cell subset ("sB-1a" cells) that mediates linked processes very early after immunization to initiate cutaneous contact sensitivity (CS), delayed-type hypersensitivity (DTH), and immune resistance to pneumococ
Publikováno v:
Molecular Immunology. 67:89-94
Monoclonal antibodies (mAb) have had tremendous success in treating a variety of cancers over the past twenty years. Yet despite their widespread clinical use, which includes treatments for haematological malignancies, there are still no approved mAb
Autor:
Stuart G. Tangye, Darren R. Jones, Robert L. Raison, Padraig McCauley Winter, Andrew T. Hutchinson
Publikováno v:
Human Immunology. 75:986-990
The monoclonal antibody, MDX-1097, is currently progressing through clinical trials as a possible therapy for multiple myeloma. MDX-1097 targets a cell membrane bound form of free immunoglobulin kappa light chain (FκLC), termed kappa myeloma antigen
Autor:
John P. Dalton, Sheila Donnelly, Padraig McCauley-Winter, Akane Tanaka, Andrew T. Hutchinson, Judith M. Greer, Raquel Alvarado, Bronwyn A. O'Brien, Ann M. Simpson, Joyce To, Mark W. Robinson, Maria E. Lund, Aakanksha Dixit
Publikováno v:
Scientific Reports
Lund, M E, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, A T, Robinson, M W, Simpson, A M, O'Brien, B M, Dalton, J P & Donnelly, S 2016, ' A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis ', Scientific Reports, vol. 6, 37789 . https://doi.org/10.1038/srep37789
Lund, M E, Greer, J, Dixit, A, Alvarado, R, McCauley-Winter, P, To, J, Tanaka, A, Hutchinson, A T, Robinson, M W, Simpson, A M, O'Brien, B M, Dalton, J P & Donnelly, S 2016, ' A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis ', Scientific Reports, vol. 6, 37789 . https://doi.org/10.1038/srep37789
Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of immune-mediated human diseases. FhHDM-1, a 68-mer peptide secreted by the helminth parasite Fasciola h
Autor:
Allen B. Edmundson, Darren R. Jones, Lynne Turnbull, Jessica L. Tacchi, Paul A. Ramsland, Steven P. Djordjevic, Andrew T. Hutchinson, Cynthia B. Whitchurch, Robert L. Raison, Joyce To, Mark Agostino, Ansha Malik, Mark Berkahn
Publikováno v:
Biochemical Journal. 454:479-489
We have described the presence of cell-membrane-associated κFLCs (free immunoglobulin light chains) on the surface of myeloma cells. Notably, the anti-κFLC mAb (monoclonal antibody) MDX-1097 is being assessed in clinical trials as a therapy for κ
Autor:
Elizabeth Yuriev, Andrew T. Hutchinson, Todd W. Mitchell, Jun Liu, Padraig McCauley Winter, Ben Capuano, Geoffrey R. Hill, Andrew C.W. Zannettino, Slavica Vuckovic, David A. Rickards, Kate Vandyke, Paul A. Ramsland, Simon H. J. Brown, Jun Lu, Philip W. Askenase
Publikováno v:
British journal of haematology. 177(3)
We have discovered that a small cationic molecule, GW4869, is cytotoxic to a subset of myeloma cell lines and primary myeloma plasma cells. Biochemical analysis revealed that GW4869 binds to anionic phospholipids such as phosphatidylserine - a lipid
Publikováno v:
Parasite Immunology. 32:305-313
Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS
Autor:
Lynne Turnbull, Maria E. Lund, Joyce To, Mark W. Robinson, John P. Dalton, Raquel Alvarado, Cynthia B. Whitchurch, Andrew T. Hutchinson, Sheila Donnelly, Stephanie N. Dowdell, Bronwyn A. O'Brien
Publikováno v:
Robinson, M W, Alvarado, R, To, J, Hutchinson, A T, Dowdell, S N, Lund, M, Turnbull, L, Whitchurch, C B, O'Brien, B A, Dalton, J P & Donnelly, S 2012, ' A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase ', The FASEB Journal, vol. 26, no. 11, pp. 4614-27 . https://doi.org/10.1096/fj.12-213876
We previously reported the identification of a novel family of immunomodulatory proteins, termed helminth defense molecules (HDMs), that are secreted by medically important trematode parasites. Since HDMs share biochemical, structural, and functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdadd41e172fcf3fc83c4f7d7a680e7
https://hdl.handle.net/10453/22179
https://hdl.handle.net/10453/22179