Zobrazeno 1 - 10
of 434
pro vyhledávání: '"Andrew T Gewirtz"'
Autor:
Melissa C Kordahi, Clara Delaroque, Marie-Florence Bredèche, Andrew T Gewirtz, Benoit Chassaing
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002289 (2023)
Dietary emulsifiers, including carboxymethylcellulose (CMC) and polysorbate 80 (P80), perturb gut microbiota composition and gene expression, resulting in a microbiota with enhanced capacity to activate host pro-inflammatory gene expression and invad
Externí odkaz:
https://doaj.org/article/fc6309c79c9c4e5b9d4ca82d15c5d111
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009497 (2021)
Western-style diet (WSD), which is high in fat and low in fiber, lacks nutrients to support gut microbiota. Consequently, WSD reduces microbiota density and promotes microbiota encroachment, potentially influencing colonization resistance, immune sys
Externí odkaz:
https://doaj.org/article/5dfa5d9e916642518c3b8fc7441da65b
Autor:
Benoit Chassaing, Andrew T Gewirtz
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195310 (2018)
Inability to maintain a stable and beneficial microbiota is associated with chronic gut inflammation, which classically manifests as colitis but may more commonly exist as low-grade inflammation that promotes metabolic syndrome. Alterations in microb
Externí odkaz:
https://doaj.org/article/851d8cb4f88d4b74a34032fd4a6ec87c
Autor:
Madison Floyd, Matthew Winn, Christian Cullen, Payel Sil, Benoit Chassaing, Dae-Goon Yoo, Andrew T Gewirtz, Joanna B Goldberg, Linda L McCarter, Balázs Rada
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005987 (2016)
Pseudomonas aeruginosa is an opportunistic pathogen causing severe infections often characterized by robust neutrophilic infiltration. Neutrophils provide the first line of defense against P. aeruginosa. Aside from their defense conferred by phagocyt
Externí odkaz:
https://doaj.org/article/2d35d866abed4523b358caf71358d0ad
Autor:
Pichatorn Suppakitjanusant, Yanling Wang, Alisa K. Sivapiromrat, Chengcheng Hu, Jose Binongo, William R. Hunt, Samuel Weinstein, Ishaan Jathal, Jessica A. Alvarez, Benoit Chassaing, Thomas R. Ziegler, Andrew T. Gewirtz, Vin Tangpricha
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 37, Iss , Pp 100362- (2024)
Background: Cystic fibrosis (CF) is a multi-organ disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). Individuals with CF often have gastrointestinal (GI) dysbiosis due to chronic inflammation and antibiotic
Externí odkaz:
https://doaj.org/article/81d45e4800dd4631983e529eba4f7ef9
Autor:
Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem. Most measles-associated morbidity and mortality arises from destruction of pre-existing immune memory by measles virus (MeV), a paramyxovirus of the morbilli
Externí odkaz:
https://doaj.org/article/c318e8440b28489e92886789df7a2812
Autor:
Juan Noriega Tejada, William A. Walters, Yanling Wang, Melissa Kordahi, Benoit Chassaing, Joseph Pickard, Gabriel Nunez, Ruth Ley, Andrew T. Gewirtz
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
We sought to better understand how intestinal microbiota confer protection against Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler flora (ASF) mice, which lack the abnormalities of germfree (GF) mice
Externí odkaz:
https://doaj.org/article/8ee09a0a1d08425bae159a8178635589
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96165 (2014)
Prior work using allogeneic bone marrow transplantation (allo-BMT) models showed that peritransplant administration of flagellin, a toll-like receptor 5 (TLR5) agonist protected murine allo-BMT recipients from CMV infection while limiting graft-vs-ho
Externí odkaz:
https://doaj.org/article/8b0fbe26ffcb452792a4e6424dd8ea33
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114292- (2024)
Summary: Interleukin (IL)-22 promotes host-microbiota homeostasis. We sought to identify microbiota metabolite(s) that drive intestinal IL-22 production. We observed that exposing Peyer’s patch cells (PPCs), ex vivo, to fecal supernatants (FSs) rec
Externí odkaz:
https://doaj.org/article/b392966c96fd4660bae69b7fb5596e2a
Autor:
Rachel M. Golonka, Beng San Yeoh, Piu Saha, Yuan Tian, John Y.L. Chiang, Andrew D. Patterson, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 719-735 (2024)
Background & Aims: Hepatocellular carcinoma (HCC) is a male-dominant disease, but targeted sex hormone therapies have not been successful. Bile acids are a potential liver carcinogen and are biomolecules with hormone-like effects. A few studies highl
Externí odkaz:
https://doaj.org/article/856932a29634485980da5951121e4bef