Zobrazeno 1 - 10
of 660
pro vyhledávání: '"Andrew T Gewirtz"'
Autor:
Pichatorn Suppakitjanusant, Yanling Wang, Alisa K. Sivapiromrat, Chengcheng Hu, Jose Binongo, William R. Hunt, Samuel Weinstein, Ishaan Jathal, Jessica A. Alvarez, Benoit Chassaing, Thomas R. Ziegler, Andrew T. Gewirtz, Vin Tangpricha
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 37, Iss , Pp 100362- (2024)
Background: Cystic fibrosis (CF) is a multi-organ disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). Individuals with CF often have gastrointestinal (GI) dysbiosis due to chronic inflammation and antibiotic
Externí odkaz:
https://doaj.org/article/81d45e4800dd4631983e529eba4f7ef9
Autor:
Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem. Most measles-associated morbidity and mortality arises from destruction of pre-existing immune memory by measles virus (MeV), a paramyxovirus of the morbilli
Externí odkaz:
https://doaj.org/article/c318e8440b28489e92886789df7a2812
Autor:
Juan Noriega Tejada, William A. Walters, Yanling Wang, Melissa Kordahi, Benoit Chassaing, Joseph Pickard, Gabriel Nunez, Ruth Ley, Andrew T. Gewirtz
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
We sought to better understand how intestinal microbiota confer protection against Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler flora (ASF) mice, which lack the abnormalities of germfree (GF) mice
Externí odkaz:
https://doaj.org/article/8ee09a0a1d08425bae159a8178635589
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114292- (2024)
Summary: Interleukin (IL)-22 promotes host-microbiota homeostasis. We sought to identify microbiota metabolite(s) that drive intestinal IL-22 production. We observed that exposing Peyer’s patch cells (PPCs), ex vivo, to fecal supernatants (FSs) rec
Externí odkaz:
https://doaj.org/article/b392966c96fd4660bae69b7fb5596e2a
Autor:
Rachel M. Golonka, Beng San Yeoh, Piu Saha, Yuan Tian, John Y.L. Chiang, Andrew D. Patterson, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 5, Pp 719-735 (2024)
Background & Aims: Hepatocellular carcinoma (HCC) is a male-dominant disease, but targeted sex hormone therapies have not been successful. Bile acids are a potential liver carcinogen and are biomolecules with hormone-like effects. A few studies highl
Externí odkaz:
https://doaj.org/article/856932a29634485980da5951121e4bef
Autor:
Erica Bonazzi, Alexis Bretin, Lucile Vigué, Fuhua Hao, Andrew D. Patterson, Andrew T. Gewirtz, Benoit Chassaing
Publikováno v:
Microbiome, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Background The observation that the intestinal microbiota is central in the development of IBD suggests that dietary fiber, the microbiota’s primary source of nourishment, could play a central role in these diseases. Accordingly, enriching
Externí odkaz:
https://doaj.org/article/5736575252b440a197a30e96d4dd0bcc
Autor:
Alisa K. Sivapiromrat, Pichatorn Suppakitjanusant, Yanling Wang, Chengcheng Hu, Jose Binongo, William R. Hunt, Samuel Weinstein, Ishaan Jathal, Jessica A. Alvarez, Benoit Chassaing, Thomas R. Ziegler, Andrew T. Gewirtz, Vin Tangpricha
Publikováno v:
Contemporary Clinical Trials Communications, Vol 38, Iss , Pp 101278- (2024)
Individuals with cystic fibrosis (CF) have dysfunctional intestinal microbiota and increased gastrointestinal (GI) inflammation also known as GI dysbiosis. It is hypothesized that administration of high-dose cholecalciferol (vitamin D3) together with
Externí odkaz:
https://doaj.org/article/a030498bba5e4000b382d8c6c47fe220
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 3, Pp 333-335 (2024)
Studies in rodents suggest that inulin supplements may be carcinogenic. We present a case implicating that this risk extends to humans. A healthy male from a family lacking history of cancer had his first cancer-screening colonoscopy at age 56. No in
Externí odkaz:
https://doaj.org/article/864d89baffcc48bd99b5e9bdbd2d9397
Autor:
Vu L. Ngo, Yanling Wang, Yadong Wang, Zhenda Shi, Robert Britton, Jun Zou, Sasirekha Ramani, Baoming Jiang, Andrew T. Gewirtz
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101393- (2024)
Background & Aims: The protection provided by rotavirus (RV) vaccines is highly heterogeneous among individuals. We hypothesized that microbiota composition might influence RV vaccine efficacy. Methods: First, we examined the potential of segmented f
Externí odkaz:
https://doaj.org/article/46652c5e97f34f33b56e6facf57a1b1d
Autor:
Maya Fayfman, Andrew T. Gewirtz, Clara Delaroque, Gerardo Blanco, Seid Gibanica, Shanthi Srinivasan, Benoit Chassaing
Publikováno v:
Metabolism Open, Vol 20, Iss , Pp 100256- (2023)
Aims: Metformin is the broadly accepted the first-line medication for diabetes. Its use, however, is limited by gastrointestinal side effects present in approximately 25% of patients. This study aimed to better understand the interplay between metfor
Externí odkaz:
https://doaj.org/article/d80ead4d7bf4402684a436eb05363782