Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrew T, DeLaitsch"'
Autor:
Zhi Yang, Kim-Marie A. Dam, Michael D. Bridges, Magnus A. G. Hoffmann, Andrew T. DeLaitsch, Harry B. Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A. Martin, Michel C. Nussenzweig, Wayne L. Hubbell, Pamela J. Bjorkman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Neutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-bindin
Externí odkaz:
https://doaj.org/article/a3f529a3512548c399bdcaadfab62202
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
Autor:
Allison L. Didychuk, Eric J. Montemayor, Tucker J. Carrocci, Andrew T. DeLaitsch, Stefani E. Lucarelli, William M. Westler, David A. Brow, Aaron A. Hoskins, Samuel E. Butcher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional a
Externí odkaz:
https://doaj.org/article/af0bae0e35e0403b9769387c02748283
Autor:
Xuanjun Wu, Jinfeng Ye, Andrew T. DeLaitsch, Zahra Rashidijahanabad, Shuyao Lang, Tayeb Kakeshpour, Yuetao Zhao, Sherif Ramadan, Paulo Vilar Saavedra, Vilma Yuzbasiyan‐Gurkan, Herbert Kavunja, Hongzhi Cao, Jeffrey C. Gildersleeve, Xuefei Huang
Publikováno v:
Angewandte Chemie. 133:24381-24390
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c72be385f0c5a20b3fce78dd1e0afe96
https://doi.org/10.1002/ange.202108610
https://doi.org/10.1002/ange.202108610
Autor:
Andrew T. DeLaitsch, Jacey R. Pridgen, Avery Tytla, Megan L. Peach, Rayleen Hu, David W. Farnsworth, Aislinn K. McMillan, Natalie Flanagan, J. Sebastian Temme, Marc C. Nicklaus, Jeffrey C. Gildersleeve
Publikováno v:
Journal of the American Chemical Society. 144(11)
Germline antibodies, the initial set of antibodies produced by the immune system, are critical for host defense, and information about their binding properties can be useful for designing vaccines, understanding the origins of autoantibodies, and dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b0d94fe2953bc8864e6ebee4239ba3
https://pubmed.ncbi.nlm.nih.gov/35282679
https://pubmed.ncbi.nlm.nih.gov/35282679
Publikováno v:
Biophysical Journal. 122:472a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382c63b22cab55e1716f57cc227816e9
https://doi.org/10.1016/j.bpj.2022.11.2532
https://doi.org/10.1016/j.bpj.2022.11.2532
Autor:
Andrew T. DeLaitsch, Nicholas Koranda, Murillo Silva, Han Gao, Leesa M. Kakutani, Amelia Escolano, Morgan E. Abernathy, Melissa Cipolla, Priyanthi N. P. Gnanapragasam, Thiago Y. Oliveira, Zhi Yang, Christopher O. Barnes, Jennifer R. Keeffe, Malcolm A. Martin, Zijun Wang, Michel C. Nussenzweig, Michael S. Seaman, Ana Gazumyan, Henna Raina, Darrell J. Irvine, Rajeev Gautam, Haoqing Wang, Pamela J. Bjorkman, Victor A. Ramos, Magnus A.G. Hoffmann, Anthony P. West, Harry B. Gristick, Yoshiaki Nishimura
Publikováno v:
Sci Transl Med
Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody co-evolution. Previous studies showed that sequential immunization with a V3-glycan-patch germline-targeting HIV-1 envelope trimer (Env) followed by vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccd03a11a1f95bb633c87e9a2975f7d
https://resolver.caltech.edu/CaltechAUTHORS:20211124-195820111
https://resolver.caltech.edu/CaltechAUTHORS:20211124-195820111
Autor:
Zhi, Yang, Kim-Marie A, Dam, Michael D, Bridges, Magnus A G, Hoffmann, Andrew T, DeLaitsch, Harry B, Gristick, Amelia, Escolano, Rajeev, Gautam, Malcolm A, Martin, Michel C, Nussenzweig, Wayne L, Hubbell, Pamela J, Bjorkman
Publikováno v:
Nature communications. 13(1)
Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83a470073d9f0024e6db1b68a65f9eec
https://pubmed.ncbi.nlm.nih.gov/35136084
https://pubmed.ncbi.nlm.nih.gov/35136084
Autor:
Paulo Vilar Saavedra, Herbert W. Kavunja, Xuanjun Wu, Jinfeng Ye, Shuyao Lang, Tayeb Kakeshpour, Jeffrey C. Gildersleeve, Hongzhi Cao, Yuetao Zhao, Vilma Yuzbasiyan-Gurkan, Zahra Rashidijahanabad, Sherif Ramadan, Andrew T DeLaitsch, Xuefei Huang
Publikováno v:
Angew Chem Int Ed Engl
Ganglioside GD2 is an attractive tumor-associated carbohydrate antigen for anti-cancer vaccine development. However, its low immunogenicity and the significant side effects observed with anti-GD2 antibodies present significant obstacles for vaccines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b1688805eea944ee6f6cd654fc6527
https://europepmc.org/articles/PMC8545922/
https://europepmc.org/articles/PMC8545922/
Autor:
Michel C. Nussenzweig, Shurong Hou, Pamela J. Bjorkman, Victor A. Ramos, Paul D. Bieniasz, Alice Cho, Theodora Hatziioannou, Kathryn E. Huey-Tubman, Magdalena Rutkowska, Christian Gaebler, Thiago Y. Oliveira, Frauke Muecksch, Zijun Wang, Marina Caskey, Anna Gazumyan, Celia A. Schiffer, Yiska Weisblum, Andrew I. Flyak, Melissa Cipolla, Justin Da Silva, Daniel Poston, Andrew T. DeLaitsch, Fabian Schmidt, Shlomo Finkin, Julio C. C. Lorenzi, Dennis Schaefer-Babajew, Christopher O. Barnes, Katrina G. Millard
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Spike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3040289ef46e509fc1d3be914b443f8d
https://resolver.caltech.edu/CaltechAUTHORS:20210802-161329765
https://resolver.caltech.edu/CaltechAUTHORS:20210802-161329765
Autor:
Kathryn E. Huey-Tubman, Andrew I. Flyak, Magdalena Rutkowska, Thiago Y. Oliveira, Anna Gazumyan, Zijun Wang, Marina Caskey, Celia A. Schiffer, Yiska Weisblum, Julio C. C. Lorenzi, Christian Gaebler, Shlomo Finkin, Victor A. Ramos, Paul D. Bieniasz, Frauke Muecksch, Michel C. Nussenzweig, Pamela J. Bjorkman, Fabian Schmidt, Dennis Schaefer-Babajew, Alice Cho, Christopher O. Barnes, Katrina G. Millard, Melissa Cipolla, Theodora Hatziioannou, Justin Da Silva, Daniel Poston, Andrew T. DeLaitsch, Shurong Hou
Publikováno v:
Immunity
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Spike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb5ac12380ac501fc4c33d534317220
https://doi.org/10.1101/2021.03.07.434227
https://doi.org/10.1101/2021.03.07.434227