Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Andrew Sunters"'
Autor:
Behzad Javaheri, Andrew Sunters, Gul Zaman, Rosemary F L Suswillo, Leanne K Saxon, Lance E Lanyon, Joanna S Price
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35726 (2012)
Although Lrp5 is known to be an important contributor to the mechanisms regulating bone mass, its precise role remains unclear. The aim of this study was to establish whether mutations in Lrp5 are associated with differences in the growth and/or apop
Externí odkaz:
https://doaj.org/article/6f5d8c4da1e54e549ee463df8aa0b3e0
Autor:
Jie Chen, Ana R Gomes, Lara J Monteiro, San Yu Wong, Lai Han Wu, Ting-Ting Ng, Christina T Karadedou, Julie Millour, Ying-Chi Ip, Yuen Nei Cheung, Andrew Sunters, Kelvin Y K Chan, Eric W-F Lam, Ui-Soon Khoo
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12293 (2010)
BackgroundThe PI3K-Akt signal pathway plays a key role in tumorigenesis and the development of drug-resistance. Cytotoxic chemotherapy resistance is linked to limited therapeutic options and poor prognosis.Methodology/principal findingsExamination of
Externí odkaz:
https://doaj.org/article/b80d4247c6cf46ed99b7e08a39ac393c
Autor:
Aline Bozec, Agamemnon E. Grigoriadis, Ethaar El-Emir, Andrew Sunters, Daniel Weekes, David Thomas, Naiara Perurena, Carolina Zandueta, Fernando Lecanda, Ana Patiño-García, Takeshi Kashima, Céline Vuillier, Isabelle Miletich
Publikováno v:
Oncogene
Osteosarcoma is the most common primary malignancy of the skeleton and is prevalent in children and adolescents. Survival rates are poor and have remained stagnant owing to chemoresistance and the high propensity to form lung metastases. In this stud
Autor:
Lee B Meakin, Andre J. Van Wijnen, Joanna S. Price, Hanna Taipaleenmaki, Noureddine Zebda, Andrew Sunters, Gary S. Stein, Gabriel L. Galea, Lance E. Lanyon, Toshihiro Sugiyama
Publikováno v:
The Journal of Biological Chemistry
Galea, G L, Meakin, L B, Sugiyama, T, Zebda, N, Sunters, A, Taipaleenmaki, H, Stein, G S, van Wijnen, A J, Lanyon, L E & Price, J S 2013, ' Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β ', Journal of Biological Chemistry, vol. 288, no. 13, pp. 9035-9048 . https://doi.org/10.1074/jbc.M112.405456
Galea, G L, Meakin, L B, Sugiyama, T, Zebda, N, Sunters, A, Taipaleenmaki, H, Stein, G S, van Wijnen, A J, Lanyon, L E & Price, J S 2013, ' Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt Antagonist Sost is Mediated by Estrogen Receptor β ', Journal of Biological Chemistry, vol. 288, no. 13, pp. 9035-9048 . https://doi.org/10.1074/jbc.M112.405456
Background: Strain and estrogens down-regulate Sost/sclerostin and stimulate osteoblastic proliferation. Results: ERα inhibition prevents proliferation. ERβ inhibition prevents Sost down-regulation by strain or estradiol. Sclerostin prevents prolif
Autor:
Gabriel L. Galea, Alaa Moustafa, Gul Zaman, Leanne Saxon, Lance E. Lanyon, Joanna S. Price, V J Armstrong, Andrew Sunters, Behzad Javaheri
Publikováno v:
The Journal of Biological Chemistry
Of the 1,328 genes revealed by microarray to be differentially regulated by disuse, or at 8 h following a single short period of osteogenic loading of the mouse tibia, analysis by predicting associated transcription factors from annotated affinities
Autor:
Andrew Sunters, Peter Underhill, Joanna S. Price, Lance E. Lanyon, Leanne Saxon, Gul Zaman, Debbie Williams, Helen Hilton
Publikováno v:
Bone
Loading-related changes in gene expression in resident cells in the tibia of female mice in the contexts of normality (WT), estrogen deficiency (WT-OVX), absence of estrogen receptor alpha (ERalpha(-/-)) and disuse due to sciatic neurectomy (WT-SN) w
Autor:
Gul Zaman, Robert M. Kypta, Joanna S. Price, Lance E. Lanyon, Andrew Sunters, V J Armstrong, Yoshiaki Kawano
Publikováno v:
The Journal of Biological Chemistry
The capacity of bones to adjust their mass and architecture to withstand the loads of everyday activity derives from the ability of their resident cells to respond appropriately to the strains engendered. To elucidate the mechanisms of strain respons
Autor:
Leanne Saxon, Toshihiro Sugiyama, Joanna S. Price, Alaa Moustafa, Gul Zaman, Lance E. Lanyon, Andrew Sunters
Publikováno v:
Bone. 45:1192-1195
In this article, we assessed the separate and combined effects of intermittent parathyroid hormone (iPTH) (1–34) and mechanical loading at trabecular and cortical sites of mouse long bones. The data suggest that, at some but not all bone sites, the
Autor:
Leanne Saxon, Alaa Moustafa, Andrew Sunters, Gul Zaman, Toshihiro Sugiyama, Lance E. Lanyon, Joanna S. Price
Publikováno v:
Bone. 43:238-248
The separate and combined effects of intermittent parathyroid hormone (iPTH) (1-34) and mechanical loading were assessed at trabecular and cortical sites of mouse long bones. Female C57BL/6 mice from 13 to 19 weeks of age were given daily injections
Autor:
Leanne Saxon, Lance E. Lanyon, V J Armstrong, Andrew Sunters, Toshihiro Sugiyama, Gul Zaman, Joanna S. Price
Publikováno v:
Clinical Reviews in Bone and Mineral Metabolism. 5:234-248
Estrogen receptors critically regulate a number of steps in the pathways in osteoblasts and osteocytes activated by exposure to dynamic mechanical strain. It is these pathways that are responsible for converting the immediate effects of strain change