Výsledky vyhledávání - "Andrew Sproul"

Akademický článek

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Autor: Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p

Externí odkaz: https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee

Zobrazit plný text záznamu

Akademický článek

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease

Autor: José Martínez-Hernández, Julie Parato, Aditi Sharma, Jean-Marc Soleilhac, Xiaoyi Qu, Ellen Tein, Andrew Sproul, Annie Andrieux, Yves Goldberg, Marie-Jo Moutin, Francesca Bartolini, Leticia Peris

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Microtubules (MTs) support a variety of neuronal functions, such as maintenance of cell structure, transport, and synaptic plasticity. Neuronal MTs are highly heterogeneous due to several tubulin isotypes and the presence of multiple post-translation

Externí odkaz: https://doaj.org/article/59729af625f84dc8af22fc3cb7c15723

Zobrazit plný text záznamu

Akademický článek

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 N141I neurons

Autor: Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy

Publikováno v: Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-20 (2017)

Abstract Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present

Externí odkaz: https://doaj.org/article/ba8e2fd651bf4f6db353af0796d70574

Zobrazit plný text záznamu

Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease

Microtubules play fundamental roles in the maintenance of neuronal processes and in synaptic function and plasticity. While dynamic microtubules are mainly composed of tyrosinated tubulin, long-lived microtubules contain detyrosinated tubulin, sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ba3a3f8ad7e9193e02bb917d8a279c
http://hdl.handle.net/11588/873715

Zobrazit plný text záznamu

Impaired α-tubulin re-tyrosination leads to synaptic dysfunction and is a feature of Alzheimer’s disease

SUMMARYIn neurons, dynamic microtubules play regulatory roles in neurotransmission and synaptic plasticity. While stable microtubules contain detyrosinated tubulin, dynamic microtubules are composed of tyrosinated tubulin, suggesting that the tubulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbac843e59bb4e67175b77772cdf023
https://hal.archives-ouvertes.fr/hal-03432440

Zobrazit plný text záznamu

NSun2 deficiency promotes tau hyperphosphorylation and neurodegeneration through epitranscriptomic regulation of miR-125b

Autor: Tein E, Andrew Sproul, Winters T, Gunnar Hargus, Yoon A. Kim, Jennifer Blaze, Ismael Santa-Maria, Andrew F. Teich, Francesca Bartolini, Schahram Akbarian, Aloke Kumar

Overproduction or suppression of certain microRNAs (miRNAs) in Alzheimer’s disease (AD) brains promote alterations in tau proteostasis and neurodegeneration. However, the mechanisms governing how specific miRNAs are dysregulated in AD brains are st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68db171173e4acdc0e948a6ca3f4842f
https://doi.org/10.1101/2021.06.16.448614

Zobrazit plný text záznamu

Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors

Autor: Saera Song, Damian J. Williams, Maria Kaufman, Karen Duff, Archana Ashok, Andrew Sproul

Publikováno v: Curr Protoc

It is essential to generate isolated populations of human neuronal subtypes in order to understand cell-type-specific roles in brain function and susceptibility to disease pathology. Here we describe a protocol for in-parallel generation of cortical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b45e63dd9b1710aa7e4962ed35deb3a
https://pubmed.ncbi.nlm.nih.gov/34102035

Zobrazit plný text záznamu

Alzheimer’s disease and the autophagic-lysosomal system

Autor: Andrew Sproul, Kyung Min Chung, Wai Haung Yu, Nancy Hernández

Publikováno v: Neuroscience Letters. 697:49-58

Age-related neurodegenerative diseases are of critical concern to the general population and research/medical community due to their health impact and socioeconomic consequences. A feature of most, if not all, neurodegenerative disorders is the prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48c5741ac371857403a143872775b1b
https://doi.org/10.1016/j.neulet.2018.05.017

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání