The influence of oxygen vacancies on piezoelectricity in samarium‐doped Pb(Mg1/3Nb2/3)O3‐PbTiO3ceramics

Autor: Andrew Simon Bell, Marcell Borbely, Yang Li

Publikováno v: Journal of the American Ceramic Society. 104:2678-2688

A study of 0.71Pb(Mg1/3Nb2/3)O3‐0.29PbTiO3 shows that, when it is doped with 2.5% Sm on the A‐site, in addition to an almost 3‐fold increase in piezoelectric charge coefficient and dielectric permittivity, there is a 2 order of magnitude reduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::878139238a279f7746f207a778e6f882
https://doi.org/10.1111/jace.17619

N-myristoyltransferase inhibition is synthetic lethal in MYC-deregulated cancers

Autor: Gregor A. Lueg, Bartlett E, Martin Janz, Probir Chakravarty, Dinis Pedro Calado, Miriam Llorian-Sopena, Mathew J. Garnett, Carr R, Monica Faronato, Andrew Simon Bell, Roberto Solari, Andrii Gorelik, Edward W. Tate, J.A. Hutton, Francesco Falciani, Eva Caamaño-Gutiérrez, Brzezicha B, Goya Grocin A

Human N-myristoyltransferases (NMTs) catalyze N-terminal protein myristoylation, a modification regulating membrane trafficking and interactions of >100 proteins. NMT is a promising target in cancer, but a mechanistic rationale for targeted therapy r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8cb3010b24b75d18b70086cbba79e19
https://doi.org/10.1101/2021.03.20.436222

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Autor: Amin S. Asfor, Robin J. Leatherbarrow, Iva Hopkins-Navratilova, Aurelie Mousnier, Sean Robinson, Anabel Guedán, Inmaculada Pérez-Dorado, Andrew Simon Bell, Joseph Newman, Anthony J. Wilkinson, Markus Ritzefeld, Roberto Solari, Edward W. Tate, J.A. Hutton, Dawid Swieboda, Sebastian L. Johnston, Tobias J. Tuthill, James A. Brannigan, Julia Morales-Sanfrutos

Publikováno v: Nature chemistry
Mousnier, A, Bell, A S, Swieboda, D P, Morales-Sanfrutos, J, Pérez-Dorado, I, Brannigan, J A, Newman, J, Ritzefeld, M, Hutton, J A, Guedán, A, Asfor, A S, Robinson, S W, Hopkins-Navratilova, I, Wilkinson, A J, Johnston, S L, Leatherbarrow, R J, Tuthill, T J, Solari, R & Tate, E W 2018, ' Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus ', Nature chemistry, vol. 10, no. 6, pp. 599-606 . https://doi.org/10.1038/s41557-018-0039-2

Rhinoviruses (RVs) are the pathogens most often responsible for the common cold, and are a frequent cause of exacerbations in asthma, chronic obstructive pulmonary disease and cystic fibrosis. Here we report the discovery of IMP-1088, a picomolar dua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48995809560d4e285bfb8d4e0d3fcd39
https://pubmed.ncbi.nlm.nih.gov/29760414

Abstract 507: Identification of CD73 and A2AR/CD73 small molecule inhibitors for cancer immunotherapy as single agents or in combination with Immune-checkpoint therapies

Autor: Michael Esquerre, Florie Bertrand, Celia bergeaud, Andrew Simon Bell, Ghislaine Marchand, Simone Culurgioni, Michael R. Paillasse, Peter N. Ray, Emilie Pelissier, Craig Johnstone, Iva Hopkins-Navratilova, Leonardo-Silvestre Hernani, Jérémy Besnard, Sean Robinson, Mark Whittaker, Joanna Lisztwan, Stephanie Versluys, Andrew L. Hopkins, Andrew Payne, Pierre Fons, Adrian Schreyer, Celine Poussereau-Pomie, Richard S. Cox

Publikováno v: Cancer Research. 79:507-507

Adenosine generated by CD73 is a key driver of immunosuppression in the hypoxic tumour microenvironment (TME) and particularly involved in angiogenic process and immunity. In immune-inflamed tumours, with CD8+ T-cell infiltrates, adenosine signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85b4f3ba878b339271551e8b3f442d29
https://doi.org/10.1158/1538-7445.am2019-507

TAK1 Inhibition in the DFG-Out Conformation

Autor: Peter G. Dodd, Thomas Ryckmans, Samantha Hughes, David G. Brown, Martin P. Green, Andrew Simon Bell, Willem P. van Hoorn, Christopher A. Hewson, Christopher Phillips, Philip Cohen, Lyn H. Jones, Iain Kilty, Robert T. Smith

Publikováno v: Chemical Biology & Drug Design. 82:500-505

The first example of an inhibitor of the kinase TAK1 that binds in the DFG-out conformation is disclosed. These preliminary studies used kinase-targeted screening and structure-based drug design to create a molecule with dual pharmacological inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0465c3bf1d741bb2e3057818672ba1a
https://doi.org/10.1111/cbdd.12169