Zobrazeno 1 - 10
of 672
pro vyhledávání: '"Andrew Saykin"'
Accelerating diversity in Alzheimer's disease research by partnering with a community advisory board
Autor:
Alex Pena‐Garcia, Ralph Richards, Mollie Richards, Christopher Campbell, Hank Mosley, Joseph Asper, Johanne Eliacin, Angelina Polsinelli, Liana Apostolova, Hugh Hendrie, Andrew Tackett, Caprice Elliott, Sarah Van Heiden, Sujuan Gao, Andrew Saykin, Sophia Wang, IADRC CAB
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 2, Pp n/a-n/a (2023)
Abstract Introduction Community advisory boards (CABs) and researcher partnerships present a promising opportunity to accelerate enrollment of underrepresented groups (URGs). We outline the framework for how the CAB and researchers at the Indiana Alz
Externí odkaz:
https://doaj.org/article/b34c2866871341dba571f3bec48880e6
Autor:
Daniel Felsky, Tina Roostaei, Kwangsik Nho, Shannon L. Risacher, Elizabeth M. Bradshaw, Vlad Petyuk, Julie A. Schneider, Andrew Saykin, David A. Bennett, Philip L. De Jager
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The consequences of microglial activation in the aging human brain remain unknown. This study quantified microglial morphology and density in the elderly human brain to show that cortical microglial activation strongly associates with AD pathogenesis
Externí odkaz:
https://doaj.org/article/5c2b0cd3de2c44ac9e972835b9851021
Autor:
Seo‐Eun Choi, Shubhabrata Mukherjee, Laura E. Gibbons, R. Elizabeth Sanders, Richard N. Jones, Douglas Tommet, Jesse Mez, Emily H. Trittschuh, Andrew Saykin, Melissa Lamar, Laura Rabin, Nancy S. Foldi, Sietske Sikkes, Roos J. Jutten, Evan Grandoit, Christine Mac Donald, Shannon Risacher, Colin Groot, Rik Ossenkoppele, for the Alzheimer's Disease Neuroimaging Initiative, Paul K. Crane
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults. Methods We used item response theory to derive composite measures for language (ADNI‐Lan) and visuospatial fu
Externí odkaz:
https://doaj.org/article/391b3e583d5d483083711329efa0e4be
INTRODUCTIONAlzheimer’s disease (AD) is heterogeneous, both clinically and neuropathologically. We investigated whether polygenic risk scores (PRSs) integrated with transcriptome profiles from AD brains can explain AD clinical heterogeneity.METHODS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74bdfd35f2709a8828c895e274f77e06
https://doi.org/10.1101/2022.12.20.22283737
https://doi.org/10.1101/2022.12.20.22283737
Autor:
Lincoln Shade, Erin Abner, Andrew Saykin, Timothy Hohman, Steven Claas, Shubhabrata Mukherjee, Mark Ebbert
BackgroundAlzheimer’s disease is highly heritable and exhibits neuropathological hallmarks of neurofibrillary tau tangles and neuritic amyloid plaques. Previous genome-wide association studies (GWAS) have identified over 70 genomic risk loci of cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90cc14c4cad152099f3919c87e5415e1
https://doi.org/10.1101/2022.12.13.22282475
https://doi.org/10.1101/2022.12.13.22282475
Autor:
Maria Kryza-Lacombe, Michelle Kassel, Philip S. Insel, Meryl A. Butters, Duygu Tosun-Turgut, Paul Aisen, Rema Raman, Susan Landau, Andrew Saykin, Arthur Toga, Clifford R. Jack, Robert Koeppe, Michael W. Weiner, Craig Nelson, Scott Mackin
Publikováno v:
The American Journal of Geriatric Psychiatry. 31:S47-S48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9203a4a37a1de1597b4dbbeee3f600b4
https://doi.org/10.1016/j.jagp.2022.12.205
https://doi.org/10.1016/j.jagp.2022.12.205
Autor:
Yunlong Liu, Edward Simpson, Kelly Nudelman, Larry Riggen, Michael Menser, Jie Ren, Jill Reiter, Jaroslaw Harezlak, Tatiana Foroud, Andrew Saykin, Steve Broglio, Michael McCrea, Paul Pasquina, Thomas McAllister
Rapid diagnosis of concussion is essential to effective treatment and recovery. Concussion biomarker research has focused primarily on blood-based protein assays to detect markers of brain injury. However, transcriptomic data provides insight into th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6852e8a1db6487f4402b4abcf29d70d2
https://doi.org/10.21203/rs.3.rs-1753658/v1
https://doi.org/10.21203/rs.3.rs-1753658/v1
Autor:
Amirhossein Modabbernia, Didac Vidal-Pineiro, Ingrid Agartz, Ole Andreassen, Rosa Ayesa-Arriola, Alessandro Bertolino, D Boomsma, Josiane Bourque, Alan Breier, Henry Brodaty, Rachel Brouwer, Jan Buitelaar, Erick Canales-Rodriguez, Xavier Caseras, Patricia Conrod, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline Crone, Greig De Zubicaray, Erin Dickie, Danai Dima, Thomas Espeseth, Stefan Frenzel, Simon Fisher, Barbara Franke, David Glahn, Hans Grabe, Dominik Grotegerd, Oliver Gruber, Amalia Guerrero-Pedraza, Raquel Gur, Ruben Gur, Catharina Hartman, Pieter Hoekstra, Hilleke Hulshoff Pol, Neda Jahanshad, Terry Jernigan, Jiyang Jiang, Andrew Kalnin, Nicole Kochan, Bernard Mazoyer, Brenna McDonald, Katie McMahon, Lars Nyberg, Jaap Oosterlaan, E Pomarol-Clotet, Joaquim Radua, Joshua Roffman, Perminder Sachdev, Theodore Satterthwaite, Raymond Salvador, Salvador Sarró, Andrew Saykin, Gunter Schumann, Jordan Smoller, Iris Sommer, Christian Tamnes, Sophia Thomopoulos, Julian Trollor, Dennis van 't Ent, Aristotle Voineskos, Yang Wang, Bernd Weber, Wei Wen, Lars T. Westlye, Heather Whalley, Lara wierenga, Steven Williams, Katharina Wittfeld, Margaret Wright, Paul Thompson, Tomas Paus, Sophia Frangou
Mechanisms underpinning neurotypical age-related variations in cortical thickness in the human brain remain insufficiently specified. Here we used cell-specific marker genes, followed by gene ontology and enrichment analyses, to quantify the associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100cbe1a960cc95ab75fb0b263efd9be
https://doi.org/10.21203/rs.3.rs-1686228/v1
https://doi.org/10.21203/rs.3.rs-1686228/v1
Autor:
Mohit Manchella, Paige Logan, Brea Perry, Siyun Peng, Lucas Hamilton, Shannon Risacher, Andrew Saykin, Liana Apostolova
Publikováno v:
Innovation in Aging. 6:240-240
Social connectedness has been linked to decreased rates of cognitive decline in later life. However, recent work suggests that particular social network characteristics (i.e., bonding and bridging) may buffer against age-related degeneration. The pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0185815154cf4e73a5df35c9dce4cf84
https://doi.org/10.1093/geroni/igac059.951
https://doi.org/10.1093/geroni/igac059.951
Autor:
Meghann Roessler, Mohit Manchella, Anmoldeep Singh, Max Coleman, Heather Francis, Andrew Saykin, Shannon Risacher, Liana Apostolova
Publikováno v:
Innovation in Aging. 6:725-725
Research on directionality of the relationship between cognitive functioning and depression is ambiguous, especially when considering implications for patients with mild cognitive impairment or Alzheimer disease (AD). Previous research suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18afefc89387622db6f661f909fdc03e
https://doi.org/10.1093/geroni/igac059.2645
https://doi.org/10.1093/geroni/igac059.2645