Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics

Autor: Manu P. Kumar, Jinyan Du, Georgia Lagoudas, Yang Jiao, Andrew Sawyer, Daryl C. Drummond, Douglas A. Lauffenburger, Andreas Raue

Publikováno v: Cell Reports, Vol 25, Iss 6, Pp 1458-1468.e4 (2018)

Summary: Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor interactions. Targeting ligand-receptor interactions (for instance, with immune checkpoint inhibitors) can provide significant benefits for patients. Ho

Externí odkaz: https://doaj.org/article/04de4b9d7c674dbbadc580b6327c748a

TFIID Enables RNA Polymerase II Promoter-Proximal Pausing

Autor: Jonathan D. Rubin, Jenna K. Rimel, Charli B. Fant, Zachary L. Maas, Dylan J. Taatjes, Meagan N. Esbin, Michael T. Marr, John Moir, Cecilia B. Levandowski, Kapil Gupta, Andrew Sawyer, Olivia Luyties, Robin D. Dowell, Imre Berger

Publikováno v: Fant, C B, Levandowski, C B, Gupta, K, Maas, Z L, Moir, J, Rubin, J D, Sawyer, A, Esbin, M N, Rimel, J K, Luyties, O, Marr, M T, Berger, I, Dowell, R D & Taatjes, D J 2020, ' TFIID Enables RNA Polymerase II Promoter-Proximal Pausing ', Molecular Cell, vol. 78, no. 4, pp. 785-793.e8 . https://doi.org/10.1016/j.molcel.2020.03.008
Mol Cell

Summary RNA polymerase II (RNAPII) transcription is governed by the pre-initiation complex (PIC), which contains TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, RNAPII, and Mediator. After initiation, RNAPII enzymes pause after transcribing less than 100 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f69ca34ab9220900fbd1069a208f44
https://doi.org/10.2139/ssrn.3429345

A multi-country study to assess the effect of a treatment with moxidectin pour-on during the dry period on milk production in dairy cows

Autor: Georg von Samson-Himmelstjerna, Jane Fanke, Hima Bindu Vanimisetti, David Bartram, Philippe Camuset, Thomas Geurden, Johannes Charlier, Janina Demeler, Andrew Sawyer, Jacques Devos

Publikováno v: Veterinary parasitology. 237

A randomized clinical study was conducted in a total of 45 commercial dairy farms in France (14 farms), Germany (28 farms) and the UK (3 farms) to evaluate the effect of an anthelmintic treatment on milk yield in the subsequent lactation. A total of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ead98b70920682b34e2201c1e6ba1f
https://pubmed.ncbi.nlm.nih.gov/28259556

Book reviews

Autor: Greville Rumble, Andrew Sawyer

Publikováno v: Open Learning: The Journal of Open, Distance and e-Learning. 25:167-175

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e5de6a057ea54b3cba6d8f1307958c4
https://doi.org/10.1080/02680511003787529

Development and function of Foxp3(+) regulatory T cells

Autor: Yuan Min, Wang, Joanna, Ghali, Geoff Yu, Zhang, Min, Hu, Ya, Wang, Andrew, Sawyer, Jimmy Jianheng, Zhou, Dhanushka A, Hapudeniya, Yiping, Wang, Qi, Cao, Guoping, Zheng, David C, Harris, Stephen I, Alexander

Publikováno v: Nephrology (Carlton, Vic.). 21(2)

Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94416d17c43ef2a4c2297551ca1aae45
https://pubmed.ncbi.nlm.nih.gov/26461175